Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma
Abstract
:1. Introduction
2. Case Presentation
3. Literature Review
4. Discussion
Patient [Ref] | Location | Complaints | Meningeal Tail Sign | Metastasis | Treatment | Radiological Manifestations | Misdiagnosis | Recurrence |
---|---|---|---|---|---|---|---|---|
17/M [12] | left posterior fossa | headache | NA | ➖ | S | obviously enhancing mass | meningioma | ➖ |
6/M [27] | bitemporal lobe | deafness, right hemiparesis, and bilateral cerebellar signs | ➖ | ➖ | S | CT: obviously enhancing mass | NA | no recurrence at 6 years |
14/F [28] | right posteromedial frontal lobe | headache | ➖ | ➖ | S+H+R | obviously enhancing mass | meningioma | recurrence at 6 months |
48/F [29] | hypothalamus | drowsiness, hyperthermia, vomiting, and headache | ➖ | ➖ | NA | NA | NA | ➖ |
19/F [29] | hypothalamus | visual loss, headaches, and drowsiness | ➖ | ➖ | S+R | NA | NA | NA |
16/M [30] | right frontoparietal convexity | progressive weakness in the left leg | NA | ➖ | S | CT: iso-density mass | meningioma | ➖ |
77/F [31] | left frontal region and clival | dementia, urinary incontinence, and anorexia | ➖ | NA | H | low SI on both T2WI and T1WI, homogeneous enhancement | chronic subdural hematoma | ➖ |
40/M [32] | left trigeminal nerve and left cavernous sinus | decrease in visual acuity or loss of visual field | ➖ | ➖ | S+H | T1WI: iso-SI, obviously enhancing | NA | ➖ |
57/M [33] | on the falx cerebri in the frontal area | headache | ➖ | ➖ | S | NA | NA | NA |
56/M [34] | pituitary stalk | frontal cephalalgias | NA | ➖ | S | T1WI: iso-SI, obviously enhancing | NA | ➖ |
30/M [34] | left cavernous sinus and tentorium cerebelli | parieto-occipital cephalalgias | NA | ➖ | S | T1WI: low-SI | NA | ➖ |
11/M [34] | vermis cerebelli | occipital cephalalgias | NA | ➖ | S | T1WI: low-SI; T2WI: low-SI at the edge of the lesion and iso-SI in the center | NA | ➖ |
40/M [34] | right cavernous sinus | right fronto-orbicular cephalalgias | NA | ➖ | S | CT: obviously enhancing; TIWI, T2WI: high-SI | meningioma | recurrence at 2 years |
11/M [35] | left frontal lobe | mild headache and nausea | ➖ | ➖ | S | T1WI: slightly high-SI T2WI: low-SI, heterogeneous enhancement | NA | ➖ |
60/F [36] | near the anterior tip of the temporal lobe | headache, grand mal seizure, and postictal confusion | ➕ | ➖ | S+R | T1WI, T2WI: low-SI, obviously enhancing | NA | ➖ |
57/F [37] | right cerebellopontine angle | right-sided ptosis and diplopia | NA | ➖ | S+R | NA | NA | NA |
17/F [1] | left frontal | left frontal headache | NA | ➖ | S | NA | NA | recurrence at 2 years |
8/M [1] | left temporal | seizure | NA | ➖ | S | NA | NA | no recurrence at 5 years |
15/M [1] | left occipital | right-sided epileptic seizure | NA | intracranial MT | S+R | obviously enhancing mass | NA | recurrence at 6 months |
18/F [38] | right temporal region | headache with occasional vomiting and blurring of vision | ➖ | ➖ | S | CT: obviously enhancing mass | meningioma | ➖ |
23/M [39] | right parieto-occipital | seizures | ➕ | ➖ | S+H | T1WI: low-SI T2WI: high-SI slightly enhancing | meningioma | no recurrence at 3 years |
13/M [19] | right frontal lobe | seizures | ➖ | ➖ | S | T2WI: hypo-intense Obviously enhancing | NA | no recurrence at 6 months |
62/M [40] | right fronto-parietooccipital and falx | focal motor seizures and right-sided tinnitus | ➕ | ➖ | S+R | T1WI: iso-SI T2WI: low-SI obviously enhancing | meningioma | ➖ |
6/M [41] | right parietal region | seizure | ➖ | ➖ | S | obviously enhancing | NA | ➖ |
41/M [42] | right occipital lobe | epileptic seizure | ➖ | intracranial MT | S | obviously enhancing | High grade glioma, brain metastasis tumor | recurrence at 11 years |
22/M [43] | under surface of left tentorium | headache | ➕ | ➖ | S | obviously enhancing | meningioma | no recurrence at 19 months |
64/F [44] | beside the anterior parasagittal region | headache | NA | ➖ | S | obviously enhancing | meningioma | no recurrence at 3 years |
70/M [45] | cranial base, frontal region, floor of the third ventricle | progressive visual disturbance | ➖ | NA | H+R | obviously enhancing | pituitary tumor, chordoma, plasmacytoma | NA |
36/F [42] | left cerebellopontine angle | left-sided headache, tinnitus, and hearing loss | NA | MT to cervical | S+R | obviously enhancing | meningioma | recurrence at 1.5 years |
52/M [46] | left cerebellopontine angle | decreased sensation on the left side of the face, hearing loss, headache, and vomiting | ➖ | ➖ | S | T1WI: iso-SI, T2WI: low-SI heterogeneous enhancement | trigeminal neurinoma, meningioma | no recurrence at 6 months |
30/F [47] | left temporo-parietal extra parenchymal | worsening headache and memory disturbance | NA | ➖ | S | CT: iso-density mass obviously enhancing | subacute subdural hematoma | ➖ |
48/F [47] | left temporal lobe | headache | NA | ➖ | S | T1: low-SI, T2: high-SI obviously enhancing | NA | ➖ |
14/F [48] | cavernous sinus, right middle cranial fossa, pterygopalatine, and infratemporal | headache | ➖ | ➖ | H+methotrexate +6-mercaptopurine | NA | NA | recurrence at 18 months |
63/M [49] | right frontal lobe | progressive left hemiparesisi | ➖ | ➖ | S | MRI: the solid part of the mass was significantly enhanced | NA | ➖ |
18/F [50] | left frontoparietal | generalized seizure | ➖ | ➖ | S | CT: calcifications and extensive ossification T1: low-SI | NA | ➖ |
58/F [51] | left fronto-temporal | headache | ➖ | ➖ | S+H | obviously enhancing mass | NA | no recurrence at 18 months |
47/M [52] | right cerebellum-pontine angle | reduced visual acuity, hearing loss, difficulty in walking, and urinary retention | NA | NA | H+R | T1WI: iso-SI, T2WI: low-SI | NA | NA |
26/F [53] | left frontotemporal region | severe headache, left eye discomfort with diplopia, left ear pain | NA | NA | high-dose dexamethasone and thalidomide | MRI: extensive enhancing, dural thickening over left frontotemporal lobes | NA | NA |
52/F [53] | right lateral ventricle | slipped and fell with head injury | NA | NA | S | NA | NA | NA |
45/M [53] | right frontal region | progressive left-sided weakness | NA | NA | S | CT: right frontal dural based tumor with peritumoral edema | NA | NA |
51/M [26] | right cerebellopontine angle | vertigo, diplopia, headache and fibrillationa of the tongue | NA | ➖ | H | obviously enhancing mass | NA | recurrence at 7 years |
56/M [54] | left basal ganglia | headaches and right-sided weakness | ➖ | ➖ | H+biopsy | TIWI: low-signal, heterogeneous enhancement | NA | ➖ |
60/M [55] | right cerebral hemisphere | gait disturbance and ataxia | ➖ | ➖ | S | T1WI, T2WI: iso-SI, obviously enhancing | NA | ➖ |
82/F [56] | right temporal region | headache and memory decrease | ➕ | ➖ | S | T1WI: slightly high-SI homogeneous enhancement | meningioma | no recurrence at 13 months |
38/M [57] | right mastoid | blurred vision and headache | ➖ | ➖ | S+H | MRI: obviously enhancing CT: bone erosion around the tumor MRV: right sigmoid sinus occlusion | NA | ➖ |
48/F [15] | right temporal region | depression, paranoid personality, and memory impairment | ➖ | ➖ | S | T2WI: iso-SI, DWI: not limited, obviously enhancing | pleomorphic xanthoastrocytoma, cystic meningioma, cystic glioma | ➖ |
20/F [58] | bilateral temporal regions | headache | NA | ➖ | S | T1WI: low-SI T2WI: mixed-SI CT: iso-density mass heterogeneous enhancement | NA | recurrence at 7 months |
10/M [2] | left transverse-sigmoid junction | mastoid tenderness and headache | ➕ | ➖ | S | CT: obviously enhancing | meningioma | ➖ |
15/M [59] | left parietal region | headache, vomiting, and lethargy | ➖ | ➖ | S | T1WI: iso-SI T2WI: low-SI obviously enhancing | NA | NA |
46/F [14] | right temporal lobe and right cerebellar hemisphere | headache, unstable walking | NA | NA | S+H | T1WI: iso-SI T2WI: low-SI MRV: right transverse sinus and sigmoid sinus occlusion | malignant meningioma | recurrence at 2.5 years |
21/F [5] | right frontal lobe | bilateral blurred vision | ➖ | ➖ | S | T1WI, T2WI: low-SI obviously enhancing | meningioma | ➖ |
54/M [14] | right frontal lobe | headache | ➕ | NA | S | T1WI: iso-SI T2WI: low-SI obviously enhancing | NA | ➖ |
27/M [16] | right frontal parietal region | seizures | ➕ | NA | S | obviously enhancing | meningioma | NA |
80/F [60] | left choroidal fissure between the amygdala and cerebral peduncle | headache, dizziness, confusion, and gait instability | ➖ | ➖ | S | obviously enhancing | aneurysm | ➖ |
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Type of Tumor | Representative Immunomarkers |
---|---|
Nodular fasciitis | CD34 (+), SMA (+), Desmin (−), S100 (−), ALK-1 (−), Ki-67(+) |
Proliferative fasciitis | SMA (+), Desmin (−), CD34 (+), S100 (−), ALK-1 (−), Ki-67 (+) |
Proliferative myositis | SMA (+), CD34 (+), Desmin (−), S100 (−), ALK-1 (−), Ki-67 (+) |
Myositis ossificans | SMA (+), Desmin (−), CD34 (−), S100(−), ALK-1 (−), Ki-67 (−) |
Ischaemic fasciitis | SMA (+), Desmin (−), CD34 (+), S100(−), ALK-1 (−), Ki-67 (+) |
Elastofibroma | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (−) |
Fibrous hamartoma of infancy | SMA (+), Desmin (−), CD34 (+), S100(−), ALK-1 (−), Ki-67 (+) |
Myofibroma/Myofibromatosis | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (+) |
Fibromatosis colli | SMA (+), Desmin (−), CD34 (−), S100 (−), ALK-1 (−), Ki-67 (−) |
Juvenile hyaline fibromatosis | Vimentin (+), CD34 (−), CD68 (−), SMA (−),S 100(−), Factor XIIIa (−) |
Inclusion body fibromatosis | Vimentin (+), CD34 (−), CD68 (−), SMA (−), S100 (−), Desmin (−) |
Fibroma of tendon sheath | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Desmoplastic fibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100(−), CD68 (−) |
Mammary-type myofibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
Calcifying aponeurotic fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Angiomyofibroblastoma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
Cellular angiofibroma | Vimentin (+), CD34 (+), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Nuchal-type fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Gardner fibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Calcifying fibrous tumor | Vimentin (+), CD34 (−), Desmin (−), SMA (−), S100 (−), CD68 (−) |
Giant cell angiofibroma | Vimentin (+), CD34 (−), Desmin (−), SMA (+), S100 (−), CD68 (−) |
Superficial fibromatoses (palmar/plantar) | SMA (+), CD34 (−), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (+) |
Desmoid-type fibromatoses | SMA (+), CD34 (−), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (+) |
Lipofibromatosis | CD34 (+), SMA (+), Desmin (−), S100 (−), Beta-catenin(CTNNB1) (−) |
Solitary fibrous tumor | CD34 (+), CD99 (+), Bcl-2 (+), CD31 (−), S100 (−), Desmin (−) |
Inflammatory myofibroblastic tumor | ALK [partly(+)], SMA (+), CD34 (+), Desmin (−), CD117 (−), S100 (−) |
Low grade myofibroblastic sarcoma | SMA (+), Desmin (−), CD34 (−), CD117 (−), ALK (−), S100 (−) |
Myxoinflammatory | CD68 (+), CD163 (+), SMA (+), Desmin (−), CD34 (−), S100 (−) |
Infantile fibrosarcoma | SMA (+), Desmin (−), CD34 (−), CD99 (−), ALK (−), S100 (−) |
Adult fibrosarcoma | SMA (+), CD34 (−), Desmin (−), S100 (−), EMA (−), CD99 (−) |
Myxofibrosarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), CD99 (−) |
Low grade fibromyxoid sarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), MUC4 (+) |
Sclerosing epithelioid fibrasarcoma | CD34 (−), SMA (−), Desmin (−), S100 (−), EMA (−), INI1(SMARCB1):(+) |
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Zhou, L.; Pan, W.; Huang, R.; Lu, Z.; You, Z.; Li, Y. Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma. Diagnostics 2023, 13, 2725. https://doi.org/10.3390/diagnostics13172725
Zhou L, Pan W, Huang R, Lu Z, You Z, Li Y. Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma. Diagnostics. 2023; 13(17):2725. https://doi.org/10.3390/diagnostics13172725
Chicago/Turabian StyleZhou, Le, Wanqian Pan, Renjun Huang, Ziwei Lu, Zhiqun You, and Yonggang Li. 2023. "Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma" Diagnostics 13, no. 17: 2725. https://doi.org/10.3390/diagnostics13172725
APA StyleZhou, L., Pan, W., Huang, R., Lu, Z., You, Z., & Li, Y. (2023). Intracranial Inflammatory Myofibroblastic Tumor: A Literature Review and a Rare Case Misdiagnosed as Acoustic Neuroma. Diagnostics, 13(17), 2725. https://doi.org/10.3390/diagnostics13172725