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Applied Sciences
Volume 15
Issue 3
10.3390/app15031338
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin

by
Ewelina Kopciuch
1,
Paula Ossowicz-Rupniewska
1,
Urszula Adamiak-Giera
2,
Anna Nowak
3,
Katarzyna Wilpiszewska
1,
Monika Białecka
2,
Łukasz Kucharski
3,
Anna Muzykiewicz-Szymańska
3,
Maciej Miernik
4,
Mirosław Halczak
4,
Maciej Romanowski
4 and
Ewa Janus
1,*
1
Department of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Pułaskiego 10, 70322 Szczecin, Poland
2
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70111 Szczecin, Poland
3
Department of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland
4
Department of General Surgery and Transplantation, Pomeranian Medical University, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(3), 1338; https://doi.org/10.3390/app15031338
Submission received: 2 December 2024 / Revised: 18 January 2025 / Accepted: 24 January 2025 / Published: 27 January 2025
(This article belongs to the Special Issue Bioactive Composite Materials: From Preparation to Application)
Versions Notes

Abstract

The compositions based on Pentravan® vehicle were prepared with (S)-naproxen, and its salt —(S)-naproxenate of L-prolinium isopropyl ester as active pharmaceutical ingredients, and two penetration enhancers from the group of sensates—menthol and Capsicum Tincture. Thermophysical properties of the mixtures of each naproxen form with enhancers were determined by DSC method. The stability of the prepared compositions after one- and three-month storage and the rheological properties were investigated. The permeation of active ingredients through the human skin was evaluated based on the in vitro study in Franz diffusion cells using the prepared compositions with each naproxen form. Increase in the permeability of the naproxen salt, especially in the presence of Capsicum Tincture, provides much faster and greater penetration of the skin by the drug. It seems to be promising the use of the developed composition in the form of pain relief and anti-inflammatory creams, occlusive compresses or topical patches. Moreover, the developed compositions can be crucial for the topical compositions made in compounding pharmacies by physicians’ recipes in individual pain pharmacotherapy.
Keywords: topical compositions; naproxen salt; permeation enhancer; human skin topical compositions; naproxen salt; permeation enhancer; human skin

Share and Cite

MDPI and ACS Style

Kopciuch, E.; Ossowicz-Rupniewska, P.; Adamiak-Giera, U.; Nowak, A.; Wilpiszewska, K.; Białecka, M.; Kucharski, Ł.; Muzykiewicz-Szymańska, A.; Miernik, M.; Halczak, M.; et al. Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin. Appl. Sci. 2025, 15, 1338. https://doi.org/10.3390/app15031338

AMA Style

Kopciuch E, Ossowicz-Rupniewska P, Adamiak-Giera U, Nowak A, Wilpiszewska K, Białecka M, Kucharski Ł, Muzykiewicz-Szymańska A, Miernik M, Halczak M, et al. Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin. Applied Sciences. 2025; 15(3):1338. https://doi.org/10.3390/app15031338

Chicago/Turabian Style

Kopciuch, Ewelina, Paula Ossowicz-Rupniewska, Urszula Adamiak-Giera, Anna Nowak, Katarzyna Wilpiszewska, Monika Białecka, Łukasz Kucharski, Anna Muzykiewicz-Szymańska, Maciej Miernik, Mirosław Halczak, and et al. 2025. "Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin" Applied Sciences 15, no. 3: 1338. https://doi.org/10.3390/app15031338

APA Style

Kopciuch, E., Ossowicz-Rupniewska, P., Adamiak-Giera, U., Nowak, A., Wilpiszewska, K., Białecka, M., Kucharski, Ł., Muzykiewicz-Szymańska, A., Miernik, M., Halczak, M., Romanowski, M., & Janus, E. (2025). Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin. Applied Sciences, 15(3), 1338. https://doi.org/10.3390/app15031338

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