The Use of Diffusion Kurtosis Imaging for the Differential Diagnosis of Alzheimer’s Disease Spectrum

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The article is good written and illustrated, however, I have two remarks:

1. Figure 3 is cut on the left side, so I couldn t see the left part of it.

2. My main question/comment is about ROI choice. As I understood from the methods, for volume quantification the authors used ROI from CAT12 program, and for DKI - ROI from AAL alas in FSL. Are these ROI complimentary and match? Are the authors sure they have measured GM, and no surrounded white matter for AAL ROI - otherwise presence of WM in ROI can influence on results. And it would be nice to illustrate the hippocampus ROI from CAT in Figure 1 (by the way, what it the difference and purpose for putting results of 2 subjects (?) illustration in Figure 1?)

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

This topic is interesting and current. Look at some points to improve it:

- The title does not reflect the whole paper. Better it can be: "The use of Diffusion Kurtosis Imaging for the Differential Diagnosis of Alzheimer's Disease Spectrum"

- "In the preclinical SCD stage..  mediators such as proinflammatory cytokines and chemokines [16]" Is there any relation to parkinson's disease? Discuss about it: --- doi: 10.1007/s00281-022-00944-6   --- doi: 10.3390/ijerph19148799  --- doi: 10.1007/s12035-020-01926-1

- "Our result showed that hippocampal atrophy became predominant at the AD stage, where volume loss is much more evident than the microstructural changes [19,47]." What do authors think about this?

- Figure 6 is too big, try to merge it.

- improve conclusion. What does this paper add new?

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The paper can be published without further review