Diabetic Pathophysiology Enhances Inflammation during Extracorporeal Membrane Oxygenation in a Rat Model

Round 1

Reviewer 1 Report

good evening! It is a very interesting paper that reflects the the mechanism of injury in diabetic’s patients undergoing ECMO and suggest treatment and preventive measures this injury I consider that it should be accepted for publication without changes

Author Response

Dear reviewer 1

We highly appreciate that the reviewer 1 have understood our concept of our study. Thank you very much for your kind consideration.

Yutaka Fujii

Reviewer 2 Report

Thank you for the opportunity the manuscript entitled “Diabetic pathophysiology enhances inflammation during extracorporeal membrane oxygenation in a rat model” by Fujii and colleagues. They present a basic science paper of the influence if diabetes on inflammation in a rat model with ECMO. There research suggest substantially enhanced inflammation, which could be a potential target of other therapies.

Thank you for this interesting manuscript.

Comments:
- Discussion: Can you discuss possible implications of the use of cytokine adsorbing systems and their potentila benefit.

Author Response

Dear reviewer 2

We highly appreciate that the reviewer 2 have understood our concept of our study. Thank you very much for your kind consideration.

Comments:
- Discussion: Can you discuss possible implications of the use of cytokine adsorbing systems and their potentila benefit.

Reply: 

We deeply appreciate your valuable comments. We agree with your opinion.

Described the application of leukocyte and cytokine removal therapy to ECMO.

: Added in Discussion: L227-231. Added references #37,38

We deeply appreciate your valuable and constructive comments.