Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants and Recruitment
2.3. Randomization
2.4. Intervention
2.5. Outcome Measures
2.6. Intervention Fidelity, Validity and Reliability
2.7. Ethical Considerations
2.8. Data Analysis
3. Results
3.1. Patients Characteristics
3.2. Effects of Intervention in Violence over Time
3.3. Effects of Intervention in Moral Reasoning and Ethical Valuation over Time
3.4. Effects of Intervention in Reasoning and Thinking Styles over Time
3.5. Effects of Intervention in Conflict Management Style and Personality Traits over Time
3.6. Repeated Measures Effects of Intervention on Study Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No. (%) | Test Statistics | p | |||||
---|---|---|---|---|---|---|---|
MRDI | TAU | ||||||
Age, mean ± SD, y | 42.24 ± 5.89 | 40.95 ± 4.01 | 0.839 | 0.406 | |||
Age of onset of schizophrenia, mean ± SD, y | 22.10 ± 4.36 | 20.55 ± 3.87 | 1.232 | 0.225 | |||
Gender | (male/female) | 16/5 | (76.2/23.8) | 17/5 | (77.3/22.7) | 0.007 | 0.933 |
Education | Secondary school | 2 | (9.5) | 2 | (9.1) | 0.767 | 0.681 |
High school | 14 | (66.7) | 17 | (77.3) | |||
Junior college/college | 5 | (23.8) | 3 | (13.6) | |||
Marriage status | Single | 16 | (76.2) | 18 | (81.8) | 0.428 | 0.934 |
Married | 2 | (9.5) | 2 | (9.1) | |||
Separated/divorced | 3 | (14.3) | 2 | (9.0) | |||
Occupation | Unemployed | 19 | (90.5) | 19 | (86.4) | 0.177 | 0.674 |
Employed | 2 | (9.5) | 3 | (13.6) | |||
Religion | Buddhism/Taoism | 9 | (42.9) | 10 | (45.5) | 0.282 | 0.868 |
Christian/others | 2 | (9.5) | 3 | (13.6) | |||
None | 10 | (47.6) | 9 | (40.9) | |||
Smoking | Yes | 9 | (42.9) | 11 | (50.0) | 0.220 | 0.639 |
No | 12 | (57.1) | 11 | (50.0) | |||
Level of smoking | 1–5 cig/day | 2 | (22.2) | 2 | (18.2) | 0.471 | 0.925 |
6–10 cig/day | 4 | (44.4) | 4 | (36.4) | |||
11–15 cig/day | 1 | (11.1) | 1 | (9.1) | |||
16–20 cig/day | 2 | (22.2) | 4 | (36.4) | |||
Alcohol use | Yes | 4 | (19.0) | 5 | (22.7) | 0.088 | 0.767 |
No | 17 | (81.0) | 17 | (77.3) | |||
Drinking frequency | ≤1 time/month | 1 | (25.0) | 1 | (20.0) | 0.032 | 0.858 |
2–4 times/month | 3 | (75.0) | 4 | (80.0) | |||
Family support | Strong | 2 | (9.5) | - | - | 2.288 | 0.515 |
Moderate | 13 | (61.9) | 16 | (72.7) | |||
Weak | 6 | (28.6) | 6 | (27.2) | |||
Primary caregiver | Parent(s) | 13 | (61.9) | 10 | (45.5) | 1.302 | 0.729 |
Sibling | 6 | (28.6) | 9 | (40.9) | |||
Others | 2 | (9.6) | 3 | (13.6) | |||
Violence patterns | Verbal violence | 19 | (90.5) | 17 | (77.3) | ||
Physical violence | 12 | (57.1) | 10 | (455) | |||
Aggression against property | 9 | (42.9) | 9 | (40.9) | |||
Auto-aggression | 2 | (9.5) | 3 | (13.6) | |||
Total scores, mean ± SD | 10.19 ± 7.64 | 8.45 ± 5.26 | 0.871 | 0.389 |
Baseline | Post-Intervention | Follow-Up | ES | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | ds b | |
Anger with resentment | 21.38 ± 3.66 | 22.27 ± 3.68 | −0.796, 0.431 | −3.155, 1.372 | 20.62 ± 3.21 | 22.36 ± 1.59 | −2.271, 0.028 | −3.296, −0.193 | 18.86 ± 2.37 | 21.59 ± 2.13 | −3.979, <0.001 | −4.121, −1.346 | |
Verbal aggression | 14.29 ± 3.08 | 15.36 ± 3.06 | −1.149, 0.257 | −2.972, 0.816 | 13.29 ± 2.51 | 15.50 ± 3.11 | −2.559, 0.014 | −3.962, −0.467 | 13.62 ± 1.43 | 16.14 ± 2.74 | −3.740, <0.001 | −3.877, −1.158 | |
Physical aggression | 27.19 ± 4.79 | 28.64 ± 3.84 | −1.093, 0.281 | −4.117, 1.225 | 23.24 ± 2.79 | 26.73 ± 2.58 | −4.255, <0.001 | −5.145, −1.833 | 21.29 ± 2.77 | 24.86 ± 2.96 | −4.079, <0.001 | −5.349, −1.807 | |
Suspicion, hostility | 22.86 ± 4.58 | 23.05 ± 2.55 | −0.167, 0.868 | −2.460, 2.084 | 21.43 ± 3.64 | 24.18 ± 2.23 | −3.002, 0.005 | −4.605, −0.901 | 19.14 ± 1.76 | 25.86 ± 2.05 | −11.473, < 0.001 | −7.904, −5.538 | |
Total | 85.24 ± 14.32 | 89.32 ± 10.95 | −1.052, 0.299 | −11.913, 3.753 | 77.90 ± 9.75 | 88.09 ± 7.76 | −3.797, <0.001 | −15.603, −4.769 | 72.95 ± 6.96 | 88.45 ± 5.49 | −8.128, <0.001 | −19.354, −11.650 | −2.47 |
Baseline | Post-Intervention | Follow-Up | ES | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | ds b | |
Moral reasoning | 52.52 ± 7.70 | 55.18 ± 8.87 | −1.047, 0.301 | −7.786, 2.470 | 64.38 ± 11.20 | 57.55 ± 7.20 | 2.390, 0.022 | 1.059, 12.612 | 72.10 ± 11.92 | 58.41 ± 6.36 | 4.727, <0.001 | 6.485, 18.342 | 1.43 |
Ethical valuation | |||||||||||||
Justice | 3.64 ± 0.65 | 3.39 ± 0.72 | 1.218, 0.230 | −0.169, 0.682 | 4.69 ± 0.60 | 4.05 ± 0.70 | 3.219, 0.003 | 0.240, 1.050 | 5.14 ± 0.80 | 4.09 ± 0.70 | 4.565, <0.001 | 0.587, 1.517 | 1.39 |
Deontology | 2.77 ± 0.44 | 2.59 ± 0.21 | 1.729, 0.091 | −0.031, 0.397 | 3.15 ± 0.41 | 2.68 ± 0.25 | 4.516, <0.001 | 0.261, 0.684 | 4.05 ± 0.48 | 2.64 ± 0.24 | 12.175, <0.001 | 1.177, 1.645 | 3.71 |
Relativism | 3.27 ± 0.37 | 3.33 ± 0.43 | −0.511, 0.612 | −0.314, 0.188 | 4.11 ± 0.60 | 3.70 ± 0.52 | 2.396, 0.021 | 0.065, 0.763 | 5.17 ± 0.57 | 3.58 ± 0.52 | 9.530, <0.001 | 1.260, 1.938 | 2.91 |
Utilitarianism | 2.62 ± 0.63 | 2.84 ± 0.62 | −1.159, 0.253 | −0.608, 0.165 | 3.43 ± 0.74 | 3.00 ± 0.63 | 2.030, 0.049 | 0.002, 0.855 | 3.98 ± 0.82 | 3.11 ± 0.73 | 3.606, <0.001 | 0.379, 1.346 | 1.12 |
Egoism | 2.83 ± 0.67 | 3.00 ± 0.59 | −0.857, 0.397 | −0.559, 0.226 | 3.21 ± 0.83 | 3.09 ± 0.71 | 0.522, 0.604 | −0.354, 0.601 | 3.79 ± 0.73 | 3.30 ± 0.73 | 2.188, 0.034 | 0.038, 0.943 | 0.67 |
Individual intention | 3.52 ± 0.60 | 3.77 ± 0.50 | −1.472, 0.149 | −0.590, 0.093 | 4.12 ± 0.82 | 3.84 ± 0.58 | 1.285, 0.206 | −0.159, 0.715 | 5.05 ± 0.68 | 3.93 ± 0.60 | 5.663, <0.001 | 0.718, 1.514 | 1.74 |
Peers intention | 4.14 ± 0.57 | 4.23 ± 0.52 | −0.502, 0.618 | −0.424, 0.255 | 4.62 ± 0.74 | 4.36 ± 0.49 | 1.338, 0.188 | −0.130, 0.641 | 4.62 ± 0.74 | 4.59 ± 0.66 | 0.131, 0.896 | −0.405, 0.461 | |
Ethical awareness | 3.24 ± 0.76 | 3.36 ± 0.72 | −0.551, 0.585 | −0.586, 0.335 | 4.14 ± 0.85 | 3.41 ± 0.73 | 3.027, 0.004 | 0.244, 1.223 | 4.90 ± 0.94 | 3.77 ± 1.02 | 3.772, <0.001 | 0.526, 1.738 | 1.15 |
Baseline | Post-Intervention | Follow-Up | ES | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | ds b | |
Rational | 5.92 ± 0.46 | 6.12 ± 0.29 | −1.672, 0.102 | −0.439, 0.041 | 6.94 ± 0.43 | 6.00 ± 0.34 | 7.828, <0.001 | 0.700, 1.186 | 7.72 ± 0.45 | 6.17 ± 0.34 | 12.594, <0.001 | 1.302, 1.800 | 3.8 |
Experiential | 7.66 ± 0.33 | 7.59 ± 0.40 | 0.622, 0.537 | −0.159, 0.300 | 7.19 ± 0.30 | 7.39 ± 0.42 | −1.759, 0.086 | −0.431, 0.030 | 6.55 ± 0.42 | 7.15 ± 0.49 | −4.233, <0.001 | −0.876, −0.310 | −1.31 |
Rational Ability | 2.91 ± 0.25 | 3.01 ± 0.27 | −1.232, 0.225 | −0.263, 0.064 | 3.47 ± 0.30 | 2.85 ± 0.29 | 6.673, <0.001 | 0.430,0 0.803 | 3.96 ± 0.33 | 3.16 ± 0.72 | 4.616, <0.001 | 0.452, 1.154 | |
Rational Engagement | 3.01 ± 0.29 | 3.11 ± 0.21 | −1.281, 0.208 | −0.256, 0.057 | 3.48 ± 0.30 | 3.15 ± 0.24 | 3.931, <0.001 | 0.159, 0.494 | 3.76 ± 0.28 | 3.18 ± 0.21 | 7.570, <0.001 | 0.422, 0.729 | |
Experiential Ability | 3.96 ± 0.24 | 3.83 ± 0.32 | 1.534, 0.133 | −0.043, 0.312 | 3.68 ± 0.22 | 3.88 ± 0.28 | −2.484, 0.017 | −0.356, −0.037 | 3.34 ± 0.37 | 3.71 ± 0.31 | −3.502, <0.001 | −0.585, −0.157 | |
Experiential Engagement | 3.70 ± 0.26 | 3.76 ± 0.24 | −0.824, 0.414 | −0.220, 0.093 | 3.50 ± 0.19 | 3.51 ± 0.26 | −0.061, 0.952 | −0.147, 0.139 | 3.22 ± 0.18 | 3.43 ± 0.27 | −2.850, 0.007 | −0.355, −0.061 |
Baseline | Post-Intervention | Follow-Up | ES | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | MRDI | TAU | t, p a | 95% CIs | ds b | |
Integrating | 1.82 ± 0.22 | 1.87 ± 0.23 | −0.672, 0.505 | −0.188, 0.094 | 1.94 ± 0.29 | 1.89 ± 0.24 | 0.603, 0.550 | −0.116, 0.215 | 1.90 ± 0.25 | 1.88 ± 0.28 | 0.184, 0.855 | −0.151, 0.181 | |
Obliging | 1.99 ± 0.34 | 1.89 ± 0.27 | 1.037, 0.306 | −0.093, 0.289 | 2.08 ± 0.30 | 1.91 ± 0.27 | 1.924, 0.061 | −0.008, 0.349 | 2.07 ± 0.21 | 1.96 ± 0.27 | 1.468, 0.150 | −0.041, 0.260 | |
Dominating | 3.43 ± 0.30 | 3.33 ± 0.36 | 0.991, 0.327 | −0.105, 0.309 | 3.03 ± 0.32 | 3.29 ± 0.41 | −2.221, 0.032 | −0.482, −0.022 | 2.60 ± 0.36 | 3.18 ± 0.31 | −5.625, <0.001 | −0.790, −0.372 | −1.72 |
Avoiding | 3.65 ± 0.53 | 3.53 ± 0.58 | 0.749, 0.458 | −0.217, 0.474 | 3.01 ± 0.33 | 3.37 ± 0.67 | −2.209, 0.033 | −0.694, −0.031 | 2.74 ± 0.26 | 3.22 ± 0.65 | −3.108, 0.003 | −0.793, −0.168 | −0.96 |
Compromising | 2.04 ± 0.33 | 1.90 ± 0.21 | 1.639, 0.109 | −0.032, 0.309 | 2.88 ± 0.59 | 2.15 ± 0.45 | 4.464, <0.001 | 0.395, 1.048 | 3.42 ± 0.71 | 2.13 ± 0.48 | 7.006, <0.001 | 0.919, 1.664 | 2.12 |
Test Statistics a | p Value | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MRDI | TAU | MRDI vs. TAU | MRDI vs. TAU | |||||||||
T1 | T2 | T3 | T1 | T2 | T3 | T1 | T2 | T3 | T1 | T2 | T3 | |
Emotional Stability | 6.00 ± 1.25 | 5.00 ± 1.12 | 4.50 ± 0.75 | 5.91 ± 1.24 | 5.73 ± 1.22 | 5.52 ± 1.28 | 0.239 | −2.024 | −3.157 | 0.812 | 0.049 | 0.003 |
Conscientiousness | 2.50 ± 0.44 | 2.93 ± 0.59 | 3.29 ± 0.68 | 2.39 ± 0.46 | 2.52 ± 0.60 | 2.64 ± 0.84 | 0.820 | 2.208 | 2.760 | 0.417 | 0.033 | 0.009 |
Openness To Experience | 2.88 ± 0.63 | 3.50 ± 0.83 | 4.02 ± 0.94 | 2.70 ± 0.59 | 2.77 ± 0.59 | 2.86 ± 0.64 | 0.947 | 3.302 | 4.746 | 0.349 | 0.002 | 0.000 |
Extraversion | 2.79 ± 0.48 | 2.83 ± 0.45 | 3.00 ± 0.44 | 2.68 ± 0.62 | 2.64 ± 0.64 | 2.82 ± 0.56 | 0.603 | 1.157 | 1.163 | 0.550 | 0.254 | 0.252 |
Agreeableness | 3.00 ± 0.44 | 3.95 ± 0.72 | 4.45 ± 0.52 | 2.84 ± 0.77 | 3.05 ± 0.72 | 3.11 ± 0.93 | 0.817 | 4.114 | 5.745 | 0.419 | <0.001 | <0.001 |
Group (Inter-Group) Effect a | Time (within) Effect b | Interaction of Group and Time (Intervention Effect) c | ||||
---|---|---|---|---|---|---|
F | p | F | p | F | p | |
Violence | 25.026 | <0.001 | 9.539 | 0.004 | 7.197 | 0.010 |
Moral reasoning | 6.417 | 0.015 | 42.325 | <0.001 | 16.592 | <0.001 |
Ethical valuation | ||||||
Justice | 20.632 | <0.001 | 53.751 | <0.001 | 6.998 | 0.012 |
Deontology | 81.638 | <0.001 | 70.874 | <0.001 | 61.443 | <0.001 |
Relativism | 32.478 | <0.001 | 112.379 | <0.001 | 67.358 | <0.001 |
Utilitarianism | 6.018 | 0.019 | 30.446 | <0.001 | 13.478 | <0.001 |
Egoism | 0.845 | 0.363 | 23.031 | <0.001 | 6.383 | 0.015 |
Reasoning and thinking styles | ||||||
Rational | 61.009 | <0.001 | 141.016 | <0.001 | 127.430 | <0.001 |
Experiential | 8.061 | 0.007 | 64.635 | <0.001 | 11.923 | <0.001 |
Conflict management style | ||||||
Integrating | 0.006 | 0.938 | 5.046 | 0.030 | 1.907 | 0.175 |
Obliging | 2.868 | 0.098 | 3.276 | 0.078 | .016 | 0.899 |
Dominating | 8.404 | 0.006 | 52.907 | <0.001 | 25.088 | <0.001 |
Avoiding | 2.592 | 0.115 | 72.228 | <0.001 | 18.164 | <0.001 |
Compromising | 38.585 | <0.001 | 67.253 | <0.001 | 34.609 | <0.001 |
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Hsu, M.-C.; Ouyang, W.-C. Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial. J. Clin. Med. 2022, 11, 1169. https://doi.org/10.3390/jcm11051169
Hsu M-C, Ouyang W-C. Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial. Journal of Clinical Medicine. 2022; 11(5):1169. https://doi.org/10.3390/jcm11051169
Chicago/Turabian StyleHsu, Mei-Chi, and Wen-Chen Ouyang. 2022. "Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial" Journal of Clinical Medicine 11, no. 5: 1169. https://doi.org/10.3390/jcm11051169
APA StyleHsu, M. -C., & Ouyang, W. -C. (2022). Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial. Journal of Clinical Medicine, 11(5), 1169. https://doi.org/10.3390/jcm11051169