Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Harrison Fetal Bladder Stent (n = 24)
3.1.1. Shunt Complications
3.1.2. Neonatal Outcome
3.2. Somatex® Intrauterine Shunt (n = 33)
3.2.1. Shunt Complications
3.2.2. Neonatal Outcome
3.3. Renal Function
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Harrison (n = 24) | Somatex (n = 33) | p-Value | |||
---|---|---|---|---|---|
Median GA at first VAS (weeks, range) | 14 + 4 | (13 + 1−16 + 6) | 15 + 1 | (12 + 4−16 + 6) | 0.496 |
Patients with shunt dislocation n, (%) | 21 | (87.5%) | 12 | (36.4%) | <0.001 |
Median GA at 1st dislocation (weeks, range) | 17 + 6 | (14 + 1−30 + 2) | 25 + 6 | (15 + 2−37 + 4) | <0.001 |
Median interval to first dislocation (days, range) | 20.6 | (1–111) | 73.9 | (1–160) | 0.002 |
Patients with re-intervention n, (%) | 8 | (33.3%) | 9 | (27.3%) | 0.771 |
Dislocations/total no. of shunts n, (%) | 24/38 | (63.2%) | 12/44 | (27.3%) | 0.002 |
Complications * (excl. dislocation) n, (%) | 13 | (54.2%) | 16 | (48.5%) | 0.790 |
Harrison | Somatex | ||
---|---|---|---|
TOP/miscarriage/IUFD n, (%) | 12/24 (50%) | 5/33 (15.2%) | 0.008 |
Live birth n, (%) | 12/24 (50%) | 28/33 (84.8%) | 0.007 |
Neonatal death n, (%) | 3/24 (12.5%) | 1/33 (3%) | 0.3 |
No. of survivors at last follow-up n, (%) | 8/24 (33.3%) | 27/33 (81.8%) | <0.001 |
No. of survivors with good renal function n, (%) | 7/8 (87.5%) | 17/25 (68%) | 0.39 |
Good renal function/entire group n, (%) | 7/24 (29.2%) | 17/33 (51.5%) | 0.11 |
Oligohydramnios > 27 weeks and good renal function n, (%) | 0/5 (0%) | 3/11 (27.3%) | 0.51 |
Harrison (n = 9) | Somatex (n = 27) | |
---|---|---|
Club foot/feet | 1 (11.1%) | 5 (18.5%) |
VACTERL/caudal regression | 1 (11.1%) | 3 (11.1%) |
Prune belly syndrome | 2 (22.2%) | 4 (14.8%) |
Complex anorectal malformation Isolated anal atresia | 2 (22.2%) 0 | 3 (11.1%) 1 (3.7%) |
Smith–Lemli–Opitz syndrome | 1 (11.1%) | 0 |
Major cardiac anomalies | 1 (11.1%) coarctation of the aorta | 1 (3.7%) aorto-pulmonary window |
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Strizek, B.; Spicher, T.; Gottschalk, I.; Böckenhoff, P.; Simonini, C.; Berg, C.; Gembruch, U.; Geipel, A. Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems. J. Clin. Med. 2022, 11, 2359. https://doi.org/10.3390/jcm11092359
Strizek B, Spicher T, Gottschalk I, Böckenhoff P, Simonini C, Berg C, Gembruch U, Geipel A. Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems. Journal of Clinical Medicine. 2022; 11(9):2359. https://doi.org/10.3390/jcm11092359
Chicago/Turabian StyleStrizek, Brigitte, Theresa Spicher, Ingo Gottschalk, Paul Böckenhoff, Corinna Simonini, Christoph Berg, Ulrich Gembruch, and Annegret Geipel. 2022. "Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems" Journal of Clinical Medicine 11, no. 9: 2359. https://doi.org/10.3390/jcm11092359
APA StyleStrizek, B., Spicher, T., Gottschalk, I., Böckenhoff, P., Simonini, C., Berg, C., Gembruch, U., & Geipel, A. (2022). Vesicoamniotic Shunting before 17 + 0 Weeks in Fetuses with Lower Urinary Tract Obstruction (LUTO): Comparison of Somatex vs. Harrison Shunt Systems. Journal of Clinical Medicine, 11(9), 2359. https://doi.org/10.3390/jcm11092359