Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity
Abstract
:1. Inborn Errors of Immunity and Gastrointestinal Manifestations
2. Eosinophilic Gastrointestinal Diseases
3. Material and Methods
4. Results
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Symptoms | Diagnosis | Treatments | |
---|---|---|---|
Eosinophilic esophagitis (EoE) | Symptoms mainly depend on the patient’s age
|
|
|
Non-EoE EGIDs
| Symptoms mainly depend on the site and the depth of intestinal inflammation
| 30 eos/HPF 52 eos/HPF 100 eos/HPF 84 eos/HPF 64 eos/HPF |
|
Author, Year [Ref] | Type of Study | IEI | EGID | Age at EGID Diagnosis | Family History | EGID Symptoms | Other Comorbidities | EGID Diagnosis | Complications | EGID Treatment |
---|---|---|---|---|---|---|---|---|---|---|
Yamakazi et al., 2016 [24] | Case report | XLA | EoC | 27 years | n.a. | Chronic diarrhea, emaciation | Recurrent infections | >20 eos/HPF | n.a. | Prednisolone |
Chen et al., 2016 [25] | Case report | CVID | EoE | 28 years | n.a. | Dysphagia, recurrent episodes of esophageal food impaction | Recurrent sinopulmonary infections | n.a. | Esophageal stenosis | Esophageal dilatation, PPI, FED, Oral fluticasone |
Hannouch et al., 2016 [26] | Case report | CVID | EoE | n.a. | n.a. | Weight loss, food impaction | Burkitt’s lymphoma | n.a. | n.a. | Oral inhaled corticosteroids |
Dixit et al., 2021 [27] | Case report | STAT3-HIES | EoE | n.a. | n.a. | Abdominal pain, dysphagia | Eczema, recurrent respiratory tract infections, cutaneous and retropharyngeal abscesses, and mycosis. | n.a. | n.a. | Dupilumab |
Scott et al., 2022 [28] | Case report | STAT1-GOF | EoE | Late adolescence | Mother with choking episodes and CMCC; a daughter with CMCC and recurrent AOM. | Choking episodes, solid and liquid dysphagia | Vaginal candidiasis, scalp fungal infection, Candida esophagitis | 22 eos/HPF | Esophageal stenosis | Balloon dilatation FED Montelukast PPI Slurry budesonide |
Tang et al., 2020 [29] | Case report | XIAP-deficiency | EoC | Infancy | Mother and sister had the mutation | Abdominal distension, perianal abscess. | Anemia, respiratory tract infections, impaired growth | n.a. | n.a. | n.a. |
Tran et al., 2022 [23] | Retrospective cohort study | CVID (43.2%), combined immunodeficiencies (21.6%), CGD (8.1%), HIES (6.8%), and ALPS (6.8%). | 61/74 (82,5%) patients with EoE and 13/74 (17.5%) with EoG, EoN, and EoC. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
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Votto, M.; Naso, M.; Brambilla, I.; Caimmi, S.; De Filippo, M.; Licari, A.; Marseglia, G.L.; Castagnoli, R. Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity. J. Clin. Med. 2023, 12, 514. https://doi.org/10.3390/jcm12020514
Votto M, Naso M, Brambilla I, Caimmi S, De Filippo M, Licari A, Marseglia GL, Castagnoli R. Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity. Journal of Clinical Medicine. 2023; 12(2):514. https://doi.org/10.3390/jcm12020514
Chicago/Turabian StyleVotto, Martina, Matteo Naso, Ilaria Brambilla, Silvia Caimmi, Maria De Filippo, Amelia Licari, Gian Luigi Marseglia, and Riccardo Castagnoli. 2023. "Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity" Journal of Clinical Medicine 12, no. 2: 514. https://doi.org/10.3390/jcm12020514
APA StyleVotto, M., Naso, M., Brambilla, I., Caimmi, S., De Filippo, M., Licari, A., Marseglia, G. L., & Castagnoli, R. (2023). Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity. Journal of Clinical Medicine, 12(2), 514. https://doi.org/10.3390/jcm12020514