Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment

Morawski, Marcin; Zhylko, Andriy; Kubiszewski, Hubert; Rochoń, Jakub; Rykowski, Paweł; Staszewski, Mikołaj; Krasnodębski, Maciej; Figiel, Wojciech; Krawczyk, Marek; Grąt, Michał

doi:10.3390/jcm14030777

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Open AccessArticle

Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment

by

Marcin Morawski

^*

,

Andriy Zhylko

,

Hubert Kubiszewski

,

Jakub Rochoń

,

Paweł Rykowski

,

Mikołaj Staszewski

,

Maciej Krasnodębski

,

Wojciech Figiel

,

Marek Krawczyk

and

Michał Grąt

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2025, 14(3), 777; https://doi.org/10.3390/jcm14030777

Submission received: 24 November 2024 / Revised: 31 December 2024 / Accepted: 23 January 2025 / Published: 24 January 2025

(This article belongs to the Special Issue Developments and Challenges in Liver Transplantation)

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Abstract

Background: Liver transplantation constitutes a well-established treatment for patients with end-stage liver disease and selected hepatic malignancies. The introduction of normothermic machine perfusion (NMP) offers a platform for both extracorporeal organ maintenance and viability assessment, especially for organs with suspicious malfunction. These organs, discarded by the majority of transplant centers (so-called ‘orphan livers’), may help to safely expand the donor pool thanks to pre-transplant appraisal; Methods: We identified all grafts undergoing normothermic ma-chine perfusions performed in the Department of General, Transplant, and Liver Surgery between December 2022 and August 2023. Their perfusion characteristics and immediate postoperative periods, as well as complications that occurred in the 90-day postoperative periods, were analyzed; Results: There were eight orphan liver grafts that underwent NMP in our Department. Postoperative complications occurring in patients receiving grafts after NMP did not seem associated with the procedure. One patient required laparotomy within the 90-day postoperative period due to biliary fistula and underwent bile duct stenting due to both fistula and nonanastomotic stricture. In one patient we observed the occurrence of anastomotic biliary stricture more than 90 days after LTx; Conclusions: NMP allows for the viability assessment of grafts with suspicious prepreservation malfunction. Some of these organs may help to expand the donor pool.

Keywords: liver transplantation; normothermic machine perfusion; liver machine perfusion; orphan livers

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MDPI and ACS Style

Morawski, M.; Zhylko, A.; Kubiszewski, H.; Rochoń, J.; Rykowski, P.; Staszewski, M.; Krasnodębski, M.; Figiel, W.; Krawczyk, M.; Grąt, M. Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment. J. Clin. Med. 2025, 14, 777. https://doi.org/10.3390/jcm14030777

AMA Style

Morawski M, Zhylko A, Kubiszewski H, Rochoń J, Rykowski P, Staszewski M, Krasnodębski M, Figiel W, Krawczyk M, Grąt M. Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment. Journal of Clinical Medicine. 2025; 14(3):777. https://doi.org/10.3390/jcm14030777

Chicago/Turabian Style

Morawski, Marcin, Andriy Zhylko, Hubert Kubiszewski, Jakub Rochoń, Paweł Rykowski, Mikołaj Staszewski, Maciej Krasnodębski, Wojciech Figiel, Marek Krawczyk, and Michał Grąt. 2025. "Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment" Journal of Clinical Medicine 14, no. 3: 777. https://doi.org/10.3390/jcm14030777

APA Style

Morawski, M., Zhylko, A., Kubiszewski, H., Rochoń, J., Rykowski, P., Staszewski, M., Krasnodębski, M., Figiel, W., Krawczyk, M., & Grąt, M. (2025). Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment. Journal of Clinical Medicine, 14(3), 777. https://doi.org/10.3390/jcm14030777

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Normothermic Machine Perfusion in Orphan Liver Graft Viability Assessment

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