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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review

by
Andrei Mihai Malutan
1,
Oana Teodora Pascu
1,*,
Doru Diculescu
1,
Razvan Ciortea
1,
Ligia Blaga
2,
Renata Nicula
1,
Carmen Bucuri
1,3,
Maria Roman
1,
Ionel Nati
1,
Cristina Mihaela Ormindean
1,
Viorela Suciu
1 and
Dan Mihu
1
1
2nd Department of Obstetrics and Gynecology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
2
Department of Neonatology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
3
Clinical Department of Surgery, “Constantin Papilian” Emergency Clinical Military Hospital, 22 G-ral Traian Mosoiu, 400132 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(3), 872; https://doi.org/10.3390/jcm14030872
Submission received: 18 November 2024 / Revised: 16 January 2025 / Accepted: 27 January 2025 / Published: 28 January 2025
(This article belongs to the Section Obstetrics & Gynecology)
Versions Notes

Abstract

Thrombocytopenia, defined as a platelet count below 150 × 109/L, is the second most common hematological abnormality after anemia found among European women in the third trimester of pregnancy. Most of the cases are mild, asymptomatic, and diagnosed accidentally. The primary causes of thrombocytopenia are linked to the pregnancy itself and include gestational thrombocytopenia (GT), autoimmune thrombocytopenia (ITP), and pre-eclampsia or HELLP syndrome-associated thrombocytopenia. First-line therapies for ITP include corticosteroids and intravenous immunoglobulin (IVIG). We came across a case of severe thrombocytopenia (platelet count of 9 × 109/L) associated with severe anemia (Hb 5.9 g/dL) at 30 weeks of gestation, with no personal or family history of bleeding disorders. A comprehensive hematologic, infectious, and rheumatological workup was performed to narrow the diagnosis. Despite aggressive corticosteroid therapy and immunoglobulin treatment, the patient’s thrombocytopenia persisted, imposing delivery at 34 weeks. This article highlights the complex presentation and management of severe thrombocytopenia and anemia during pregnancy.
Keywords: thrombocytopenia; autoimmune; pregnancy; diagnostic thrombocytopenia; autoimmune; pregnancy; diagnostic

Share and Cite

MDPI and ACS Style

Malutan, A.M.; Pascu, O.T.; Diculescu, D.; Ciortea, R.; Blaga, L.; Nicula, R.; Bucuri, C.; Roman, M.; Nati, I.; Ormindean, C.M.; et al. Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review. J. Clin. Med. 2025, 14, 872. https://doi.org/10.3390/jcm14030872

AMA Style

Malutan AM, Pascu OT, Diculescu D, Ciortea R, Blaga L, Nicula R, Bucuri C, Roman M, Nati I, Ormindean CM, et al. Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review. Journal of Clinical Medicine. 2025; 14(3):872. https://doi.org/10.3390/jcm14030872

Chicago/Turabian Style

Malutan, Andrei Mihai, Oana Teodora Pascu, Doru Diculescu, Razvan Ciortea, Ligia Blaga, Renata Nicula, Carmen Bucuri, Maria Roman, Ionel Nati, Cristina Mihaela Ormindean, and et al. 2025. "Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review" Journal of Clinical Medicine 14, no. 3: 872. https://doi.org/10.3390/jcm14030872

APA Style

Malutan, A. M., Pascu, O. T., Diculescu, D., Ciortea, R., Blaga, L., Nicula, R., Bucuri, C., Roman, M., Nati, I., Ormindean, C. M., Suciu, V., & Mihu, D. (2025). Autoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review. Journal of Clinical Medicine, 14(3), 872. https://doi.org/10.3390/jcm14030872

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