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Volume 14
Issue 3
10.3390/jcm14030941
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Article

Bone Densitometry Parameters in Females with Ehlers–Danlos Syndrome—Does the Hypermobile Subtype Increase the Risk of Low Bone Mass in Patients with Ehlers–Danlos Syndrome?

by
Bernadetta Kałuża
1,2,*,
Ivan Rychlik
3,
Jan Domański
1,2,
Aleksandra Żuk-Łapan
1,2,
Emilia Babula
1,2,
Iga Poprawa
1,2,
Jakub Podstawka
1,2,
Ewa Kowalów
1,2 and
Edward Franek
1,4
1
Department of Internal Medicine, Endocrinology, and Diabetology National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland
2
Students Scientific Group of the Medical University of Warsaw at the Department of Internal Medicine, Endocrinology and Diabetology, National Medical Institute of the Ministry of the Interior and Administration, 02-091 Warsaw, Poland
3
Department of Internal Medicine, Third Faculty of Medicine, Charles University, and Královské Vinohrady University Hospital, 100 00 Prague, Czech Republic
4
Department of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(3), 941; https://doi.org/10.3390/jcm14030941 (registering DOI)
Submission received: 14 January 2025 / Revised: 25 January 2025 / Accepted: 30 January 2025 / Published: 1 February 2025
(This article belongs to the Section Endocrinology & Metabolism)
Versions Notes

Abstract

Background: The purpose of this study was to assess bone densitometry parameters in patients with classical and hypermobile Ehlers–Danlos syndrome (EDS) and to determine whether the hypermobile subtype increases the risk of low bone mass, which is particularly important in this patient group, since the genetic mutation responsible for this subtype is still unknown. Material and Methods: In order to conduct this study, we collaborated with the EDS society in Poland. A total of 30 females of reproductive age who were included in the study were divided into two groups: Group 1—those with classical EDS (n = 9) and Group 2—those with hypermobile EDS (n = 21). Routine laboratory test results, bone turnover markers, and densitometry parameters were evaluated and compared. Results: The study groups showed no differences in terms of densitometry parameters or markers of calcium–phosphate metabolism. A multivariate logistic analysis demonstrated no increase in the risk of low bone mass (defined as a Z-score lower than -2) in patients with hypermobile EDS (OR 0.067 [95% Cl 0.0–20.927]; p = 0.356). Conclusions: The hypermobile subtype of EDS does not increase the risk of low bone mass; there were no significant differences between patients with hypermobile EDS and those with classical EDS in terms of either densitometry parameters or markers of calcium–phosphate metabolism. Although patients with hypermobile EDS are not at a higher risk of developing low bone mineral density, they should be regularly monitored for any calcium and phosphate metabolism abnormalities.
Keywords: Ehlers–Danlos syndrome; bone densitometry; low bone mass Ehlers–Danlos syndrome; bone densitometry; low bone mass

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MDPI and ACS Style

Kałuża, B.; Rychlik, I.; Domański, J.; Żuk-Łapan, A.; Babula, E.; Poprawa, I.; Podstawka, J.; Kowalów, E.; Franek, E. Bone Densitometry Parameters in Females with Ehlers–Danlos Syndrome—Does the Hypermobile Subtype Increase the Risk of Low Bone Mass in Patients with Ehlers–Danlos Syndrome? J. Clin. Med. 2025, 14, 941. https://doi.org/10.3390/jcm14030941

AMA Style

Kałuża B, Rychlik I, Domański J, Żuk-Łapan A, Babula E, Poprawa I, Podstawka J, Kowalów E, Franek E. Bone Densitometry Parameters in Females with Ehlers–Danlos Syndrome—Does the Hypermobile Subtype Increase the Risk of Low Bone Mass in Patients with Ehlers–Danlos Syndrome? Journal of Clinical Medicine. 2025; 14(3):941. https://doi.org/10.3390/jcm14030941

Chicago/Turabian Style

Kałuża, Bernadetta, Ivan Rychlik, Jan Domański, Aleksandra Żuk-Łapan, Emilia Babula, Iga Poprawa, Jakub Podstawka, Ewa Kowalów, and Edward Franek. 2025. "Bone Densitometry Parameters in Females with Ehlers–Danlos Syndrome—Does the Hypermobile Subtype Increase the Risk of Low Bone Mass in Patients with Ehlers–Danlos Syndrome?" Journal of Clinical Medicine 14, no. 3: 941. https://doi.org/10.3390/jcm14030941

APA Style

Kałuża, B., Rychlik, I., Domański, J., Żuk-Łapan, A., Babula, E., Poprawa, I., Podstawka, J., Kowalów, E., & Franek, E. (2025). Bone Densitometry Parameters in Females with Ehlers–Danlos Syndrome—Does the Hypermobile Subtype Increase the Risk of Low Bone Mass in Patients with Ehlers–Danlos Syndrome? Journal of Clinical Medicine, 14(3), 941. https://doi.org/10.3390/jcm14030941

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