Intrahepatic Cholestasis in Pregnancy: Review of the Literature
Abstract
:1. Introduction
2. Epidemiology and Etiology of Intrahepatic Cholestasis of Pregnancy
3. Clinical Symptoms of ICP
4. Laboratory Diagnostics of ICP
5. Therapy of ICP
Author Contributions
Funding
Conflicts of Interest
References
- McIlvride, S.; Dixon, P.H.; Williamson, C. Bile acids and gestation. Mol. Asp. Med. 2017, 56, 90–100. [Google Scholar] [CrossRef] [PubMed]
- Angueira, A.R.; Ludvik, A.E.; Reddy, T.E.; Wicksteed, B.; Lowe, W.L., Jr.; Layden, B.T. New insights into gestational glucose metabolism: Lessons learned from 21st century approaches. Diabetes 2015, 64, 327–334. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Williamson, C.; Geenes, V. Intrahepatic cholestasis of pregnancy. Obstet. Gynecol. 2014, 124, 120–133. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lee, N.M.; Brady, C.W. Liver disease in pregnancy. World J. Gastroenterol. 2009, 15, 897–906. [Google Scholar] [CrossRef]
- Floreani, A.; Gervasi, M.T. New Insights on Intrahepatic Cholestasis of Pregnancy. Clin. Liver Dis. 2016, 20, 177–189. [Google Scholar] [CrossRef]
- Jacquemin, E.; Cresteil, D.; Manouvrier, S.; Boute, O.; Hadchouel, M. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet 1999, 353, 210–211. [Google Scholar] [CrossRef]
- Kawakita, T.; Parikh, L.I.; Ramsey, P.S.; Huang, C.C.; Zeymo, A.; Fernandez, M.; Smith, S.; Iqbal, S.N. Predictors of adverse neonataloutcomes in intrahepatic cholestasis of pregnancy. Am. J. Obstet. Gynecol. 2015, 213, 570. [Google Scholar] [CrossRef] [Green Version]
- Poupon, R.; Rosmorduc, P.; Boëlle, P.Y.; Chrétien, Y.; Corpechot, C.; Chazouillères, O.; Housset, C.; Barbu, V. Genotype-phenotype relationships in the low-phospholipid-associated cholelithiasis syndrome: A study of 156 consecutive patients. Hepatology 2013, 58, 1105–1110. [Google Scholar] [CrossRef]
- Rosmorduc, O.; Poupon, R. Low phospholipid associated cholelithiasis: Association with mutation in the MDR3/ABCB4 gene. Orphanet J. Rare Dis. 2007, 2, 29. [Google Scholar] [CrossRef] [Green Version]
- Meier, Y.; Zodan, T.; Lang, C.; Zimmermann, R.; Kullak-Ublick, G.A.; Meier, P.J.; Stieger, B.; Pauli-Magnus, C. Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. World J. Gastroenterol. 2008, 14, 38–45. [Google Scholar] [CrossRef] [Green Version]
- Lang, C.; Meier, Y.; Stieger, B.; Beuers, U.; Lang, T.; Kerb, R.; Kullak-Ublick, G.A.; Meier, P.J.; Pauli-Magnus, C. Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet. Genom. 2007, 17, 47–60. [Google Scholar] [CrossRef] [PubMed]
- Dixon, P.H.; Wadsworth, C.A.; Chambers, J.; Donnelly, J.; Cooley, S.; Buckley, R.; Mannino, R.; Jarvis, S.; Syngelaki, A.; Geenes, V.; et al. A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy. Am. J. Gastroenterol. 2014, 109, 76–84. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Müllenbach, R.; Bennett, A.; Tetlow, N.; Patel, N.; Hamilton, G.; Cheng, F.; Chambers, J.; Howard, R.; Taylor-Robinson, S.D.; Williamson, C. ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy. Gut 2005, 54, 29–834. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Van Mil, S.W.; Milona, A.; Dixon, P.H.; Mullenbach, R.; Geenes, V.L.; Chambers, J.; Shevchuk, V.; Moore, G.E.; Lammert, F.; Glantz, A.G.; et al. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 2007, 133, 507–516. [Google Scholar] [CrossRef] [PubMed]
- Geier, A.; Dietrich, O.G.; Gerloff, T.; Haendly, J.; Kullak-Ublick, G.A.; Stieger, B.; Meier, P.J.; Matern, S.; Gartung, C. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Biochim. Biophys. Acta 2003, 1609, 87–94. [Google Scholar] [CrossRef] [Green Version]
- Barth, A.; Klinger, G.; Rost, M. Influence of ethinyloestradiolpropanolsulphonate on serum bile acids in healthy volunteers. Exp. Toxicol. Pathol. 2003, 54, 381–386. [Google Scholar] [CrossRef]
- Abu-Hayyeh, S.; Papacleovoulou, G.; Lövgren-Sandblom, A.; Tahir, M.; Oduwole, O.; Jamaludin, N.A. Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype. Hepatology 2013, 57, 716–726. [Google Scholar] [CrossRef] [Green Version]
- Abu-Hayyeh, S.; Williamson, C. Progesterone metabolites as farnesoid X receptor inhibitors. Hepatology 2014, 60, 1815–1817. [Google Scholar] [CrossRef]
- Dixon, P.H.; Williamson, C. The pathophysiology of intrahepatic cholestasis of pregnancy. Clin. Res. Hepatol. Gastroenterol. 2016, 40, 141–153. [Google Scholar] [CrossRef]
- Lee, R.H.; Kwok, K.M.; Ingles, S.; Wilson, M.L.; Mullin, P.; Incerpi, M.; Pathak, B.; Goodwin, T.M. Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy. Am. J. Perinatol. 2008, 25, 341–345. [Google Scholar] [CrossRef]
- Glantz, A.; Marschall, H.U.; Mattsson, L.A. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetalcomplication rates. Hepatology 2004, 40, 467–474. [Google Scholar] [CrossRef]
- Kondrackiene, J.; Kupcinskas, L. Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems. World J. Gastroenterol. 2008, 14, 5781–5788. [Google Scholar] [CrossRef]
- Castaño, G.; Lucangioli, S.; Sookoian, S.; Mesquida, M.; Lemberg, A.; Di Scala, M.; Franchi, P.; Carducci, C.; Tripodi, V. Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy. Clin. Sci. 2006, 110, 459–465. [Google Scholar] [CrossRef] [Green Version]
- Ovadia, C.; Seed, P.T.; Sklavounos, A.; Geenes, V.; Di Ilio, C.; Chambers, J.; Kohari, K.; Bacq, Y.; Bozkurt, N.; Brun-Furrer, R.; et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: Results of aggregate and individual patient data meta-analyses. Lancet 2019, 393, 899–909. [Google Scholar] [CrossRef] [Green Version]
- Germain, A.M.; Kato, S.; Carvajal, J.A.; Valenzuela, G.J.; Valdes, G.L.; Glasinovic, J.C. Bile acids increase response and expression of human myometrial oxytocin receptor. Am. J. Obstet. Gynecol. 2003, 189, 577–582. [Google Scholar] [CrossRef]
- Geenes, V.; Chappell, L.C.; Seed, P.T.; Steer, P.J.; Knight, M.; Williamson, C. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study. Hepatology 2014, 59, 1482–1491. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sentilhes, L.; Verspyck, E.; Pia, P.; Marpeau, L. Fetal death in a patient with intrahepatic cholestasis of pregnancy. Obstet. Gynecol. 2006, 107, 458–460. [Google Scholar] [CrossRef] [PubMed]
- Sentilhes, L.; Verspyck, E.; Roman, H.; Marpeau, L. Intrahepatic cholestasis of pregnancy and bile acid levels. Hepatology 2005, 3, 737–738. [Google Scholar] [CrossRef]
- Huang, W.M.; Gowda, M.; Donnelly, J.G. Bile acid ratio in diagnosis of intrahepatic cholestasis of pregnancy. Am. J. Perinatol. 2009, 26, 291–294. [Google Scholar] [CrossRef]
- Prati, D.; Taioli, E.; Zanella, A.; Della Torre, E.; Butelli, S.; Del Vecchio, E.; Vianello, L.; Zanuso, F.; Mozzi, F.; Milani, S.; et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann. Intern. Med. 2002, 137, 1–10. [Google Scholar] [CrossRef]
- Ozyuncu, O.; Orgul, G.; Ozten, G.; Yurdakok, M.; Beksac, M.S. Outpatient versus inpatient follow-up for intrahepatic cholestasis of pregnancy. Clin. Exp. Hepatol. 2019, 5, 289–293. [Google Scholar] [CrossRef]
- Zhang, L.; Liu, X.H.; Qi, H.B.; Li, Z.; Fu, X.D.; Chen, L.; Shao, Y. Ursodeoxycholic acid and Sadenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: A multi-centered randomized controlled trial. Eur. Rev. Med. Pharmacol. Sci. 2015, 19, 3770–3776. [Google Scholar]
- Glantz, A.; Reilly, S.J.; Benthin, L.; Lammert, F.; Mattsson, L.A.; Marschall, H.U. Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine. Hepatology 2008, 47, 544–551. [Google Scholar] [CrossRef] [PubMed]
- Chappell, L.C.; Bell, J.L.; Smith, A.; Linsell, L.; Juszczak, E.; Dixon, P.H.; Chambers, J.; Hunter, R.; Dorling, J.; Williamson, C.; et al. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): A randomised controlled trial. Lancet 2019, 394, 849–860. [Google Scholar] [CrossRef] [Green Version]
- Chappell, L.C.; Gurung, V.; Seed, P.T.; Chambers, J.; Williamson, C.; Thornton, J.G. PITCH Study Consortium. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: Semifactorialrandomised clinical trial. BMJ 2012, 344, e3799. [Google Scholar] [CrossRef] [Green Version]
- Bicocca, M.J.; Sperling, J.D.; Chauhan, S.P. Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018, 231, 180–187. [Google Scholar] [CrossRef] [PubMed]
- Puljic, A.; Kim, E.; Page, J.; Esakoff, T.; Shaffer, B.; LaCoursiere, D.Y.; Caughey, A.B. The risk of infant and fetal death by each additional week of expectant management in intrahepatic cholestasis of pregnancy by gestational age. Am. J. Obstet. Gynecol. 2015, 212, 667. [Google Scholar] [PubMed]
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Piechota, J.; Jelski, W. Intrahepatic Cholestasis in Pregnancy: Review of the Literature. J. Clin. Med. 2020, 9, 1361. https://doi.org/10.3390/jcm9051361
Piechota J, Jelski W. Intrahepatic Cholestasis in Pregnancy: Review of the Literature. Journal of Clinical Medicine. 2020; 9(5):1361. https://doi.org/10.3390/jcm9051361
Chicago/Turabian StylePiechota, Joanna, and Wojciech Jelski. 2020. "Intrahepatic Cholestasis in Pregnancy: Review of the Literature" Journal of Clinical Medicine 9, no. 5: 1361. https://doi.org/10.3390/jcm9051361
APA StylePiechota, J., & Jelski, W. (2020). Intrahepatic Cholestasis in Pregnancy: Review of the Literature. Journal of Clinical Medicine, 9(5), 1361. https://doi.org/10.3390/jcm9051361