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Volume 13
Issue 2
10.3390/diseases13020040
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Article

A Retrospective Review of 28 Cases of Pediatric Malignant Renal Tumors at a Single Institution

by
Takafumi Kawano
1,
Koshiro Sugita
1,
Ryuta Masuya
2,
Nanako Nishida
1,
Ayaka Nagano
1,
Masakazu Murakami
1,
Keisuke Yano
1,
Shun Onishi
1,
Toshio Harumatsu
1,
Tatsuro Nakamura
3,
Koji Yamada
1,
Waka Yamada
1,
Mitsuru Muto
1,
Yuichi Kodama
3,
Takuro Nishikawa
3,
Tatsuru Kaji
4,
Yasuhiro Okamoto
3 and
Satoshi Ieiri
1,*
1
Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, Kagoshima 890-8520, Japan
2
Department of Gastrointestinal Surgery and Surgical Oncology, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
3
Department of Pediatrics, Kagoshima University School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8520, Japan
4
Department of Pediatric Surgery, Kurume University School of Medicine, Kurume 830-0011, Japan
*
Author to whom correspondence should be addressed.
Diseases 2025, 13(2), 40; https://doi.org/10.3390/diseases13020040
Submission received: 13 January 2025 / Revised: 28 January 2025 / Accepted: 30 January 2025 / Published: 31 January 2025
Review Reports Versions Notes

Abstract

Advances in treatment have dramatically improved the outcomes of pediatric renal malignancies. We reviewed cases of renal malignant tumors that were managed in our institution. The patients’ background factors, pathological diagnoses, stages, outcomes and late complications were retrospectively reviewed using medical records of 28 patients with renal tumors who were treated at our institution from 1984 to 2022. Wilms’ tumors were recognized in 24 patients (85.7%), all of whom had favorable histology. Wilms’ tumors were Stage I in six patients (6/24; 25.0%), Stage II in nine patients (9/24; 37.5%), Stage III in five patients (5/24; 20.8%), Stage IV in two patients (2/24; 8.3%), and Stage V in two patients (2/24; 8.3%). Two patients (7.1%) with clear cell sarcoma of the kidney both had Stage I disease. One patient had Stage IV rhabdoid sarcoma of the kidney (3.5%), and one had Stage IV renal cell carcinoma (3.5%). The overall 5-year survival rate was 85.2% for all renal malignancies. Late complications included chronic renal failure in four patients (14.2%). The outcomes are comparable to those reported previously. However, the prognosis of MRTK and renal cell carcinoma remained poor in advanced cases; thus, another therapeutic protocol should be established.
Keywords: Wilms’ tumor; malignant rhabdoid tumor; renal cell carcinoma; children Wilms’ tumor; malignant rhabdoid tumor; renal cell carcinoma; children

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MDPI and ACS Style

Kawano, T.; Sugita, K.; Masuya, R.; Nishida, N.; Nagano, A.; Murakami, M.; Yano, K.; Onishi, S.; Harumatsu, T.; Nakamura, T.; et al. A Retrospective Review of 28 Cases of Pediatric Malignant Renal Tumors at a Single Institution. Diseases 2025, 13, 40. https://doi.org/10.3390/diseases13020040

AMA Style

Kawano T, Sugita K, Masuya R, Nishida N, Nagano A, Murakami M, Yano K, Onishi S, Harumatsu T, Nakamura T, et al. A Retrospective Review of 28 Cases of Pediatric Malignant Renal Tumors at a Single Institution. Diseases. 2025; 13(2):40. https://doi.org/10.3390/diseases13020040

Chicago/Turabian Style

Kawano, Takafumi, Koshiro Sugita, Ryuta Masuya, Nanako Nishida, Ayaka Nagano, Masakazu Murakami, Keisuke Yano, Shun Onishi, Toshio Harumatsu, Tatsuro Nakamura, and et al. 2025. "A Retrospective Review of 28 Cases of Pediatric Malignant Renal Tumors at a Single Institution" Diseases 13, no. 2: 40. https://doi.org/10.3390/diseases13020040

APA Style

Kawano, T., Sugita, K., Masuya, R., Nishida, N., Nagano, A., Murakami, M., Yano, K., Onishi, S., Harumatsu, T., Nakamura, T., Yamada, K., Yamada, W., Muto, M., Kodama, Y., Nishikawa, T., Kaji, T., Okamoto, Y., & Ieiri, S. (2025). A Retrospective Review of 28 Cases of Pediatric Malignant Renal Tumors at a Single Institution. Diseases, 13(2), 40. https://doi.org/10.3390/diseases13020040

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