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Sci. Pharm.
Volume 75
Issue 3
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 75, Issue 3 (September 2007) – 3 articles , Pages 97-146

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385 KiB  
Article
Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7)
by Rana Abu-Dahab and Fatma Afifi
Sci. Pharm. 2007, 75(3), 121-146; https://doi.org/10.3797/scipharm.2007.75.121 - 28 Sep 2007
Cited by 107 | Viewed by 3986
Abstract
76 ethanolic extracts of medicinal herbs from the Jordanian flora, belonging to 67 species and 34 families, were evaluated for their antiproliferative activity on a breast cancer cell line (MCF7). The cells were cultured in RPMI 1640 medium and incubated with the extracts [...] Read more.
76 ethanolic extracts of medicinal herbs from the Jordanian flora, belonging to 67 species and 34 families, were evaluated for their antiproliferative activity on a breast cancer cell line (MCF7). The cells were cultured in RPMI 1640 medium and incubated with the extracts for 72 hours. Sulphorhodamine B (SRB) assay was used to test cytotoxicity.
From the tested crude extracts, Inula graveolens, Salvia dominica, Conyza canadiensis and Achillea santolina showed potent antiproliferative activity and the activity resided in the chloroform/ethanolic extracts. The most active plant was I. graveolens with an IC50 of 3.83 μg/ml. Phytochemical screening indicated the presence of flavonoids, terpenoids, and phenolics in all active extracts. These results indicate the possible potential use of medicinal plants from the Jordanian flora as antineoplastic agents. Full article
305 KiB  
Article
Two New Saponins from Solidago gigantea
by Angelika Lendl and Gottfried Reznicek
Sci. Pharm. 2007, 75(3), 111-120; https://doi.org/10.3797/scipharm.2007.75.111 - 28 Sep 2007
Cited by 5 | Viewed by 1629
Abstract
Two new triterpenoid saponins, named giganteasaponin 5 and giganteasaponin 6, were isolated from the aboveground parts of Solidago gigantea and were defined to be 3-O-[β-D-Apio-D-furanosyl-(1→3)- β-D-glucopyranosyl-(1→3)- β-D-glucopyranosyl]- 28-O {α-L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-( 1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-Dxylopyranosyl}- Bayogenin respectively 3-O- [β-D-Apio-D-furanosyl-(1→3)- β-Dgluco- pyranosyl-(1→3)- β-D-glucopyranosyl]-28-O {β-D-galactopyranosyl-(1→2)- [...] Read more.
Two new triterpenoid saponins, named giganteasaponin 5 and giganteasaponin 6, were isolated from the aboveground parts of Solidago gigantea and were defined to be 3-O-[β-D-Apio-D-furanosyl-(1→3)- β-D-glucopyranosyl-(1→3)- β-D-glucopyranosyl]- 28-O {α-L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-( 1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-Dxylopyranosyl}- Bayogenin respectively 3-O- [β-D-Apio-D-furanosyl-(1→3)- β-Dgluco- pyranosyl-(1→3)- β-D-glucopyranosyl]-28-O {β-D-galactopyranosyl-(1→2)- α- L-rhamnopyranosyl-(1→3)- β-D-xylopyranosyl-(1→4)- [β-D-xylopyranosyl-(1→3)]- α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→3)]- β-D-xylopyranosyl}- Bayogenin. The structures were established on the basis of chemical degradation, extensive MS studies and NMR investigations as well. Full article
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Article
In Vitro Release Studies on Multiple and Simple Emulsions of α-Tocopherol with Pistacia Leaves
by Ö. Özer, B. Kıvçak, B. Mutlu, S. Akay, H. Sağlam and S. Tömek
Sci. Pharm. 2007, 75(3), 97-110; https://doi.org/10.3797/scipharm.2007.75.97 - 28 Sep 2007
Cited by 5 | Viewed by 1232
Abstract
α-Tocopherol is the most effective lipid soluble natural antioxidant and free-radical scavenger. The present study aimed to evaluate the performance of the extracts of Pistacia lentiscus, P. lentiscus var. chia and P. terebinthus leaves as additives on in vitro release of α-tocopherol. [...] Read more.
α-Tocopherol is the most effective lipid soluble natural antioxidant and free-radical scavenger. The present study aimed to evaluate the performance of the extracts of Pistacia lentiscus, P. lentiscus var. chia and P. terebinthus leaves as additives on in vitro release of α-tocopherol. The α-tocopherol content of Pistacia extracts were determined and the release was investigated from w/o/w multiple emulsion, w/o and o/w simple emulsions through cellulose acetate and cellulose nitrate membranes by using HPLC-UV method. As significant increase in the extent of α-tocopherol release was observed with the addition of Pistacia extracts in all emulsions. They could be suggested as suitable additives in α-tocopherol containing formulations. Full article
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