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Volume 77
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Article

The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells

by
Henryk MARONA
1,
Elżbieta PĘKALA
1,*,
Agnieszka GUNIA
1,
Zenon CZUBA
2,
Edward SZNELER
3,
Tadeusz SADOWSKI
4 and
Wojciech KRÓL
2
1
Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-680 Cracow, Poland
2
Department of Microbiology and Immunology, Medical University of Silesia, Jordana 19, 41-808 Zabrze- Rokitnica, Poland
3
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Cracow, Poland
4
Department of Municipal Hygiene, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(4), 743-754; https://doi.org/10.3797/scipharm.0906-08
Submission received: 9 June 2009 / Accepted: 16 October 2009 / Published: 17 October 2009
Versions Notes

Abstract

The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2- phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen- 4-yl)acetic acid), and appropriate xanthone derivatives (1–7) was determined. Also the toxicity of the FAA, MFAA ((6-methyl-4-oxo-2-aryl-4H-chromen- 8-yl)acetic acid), XAA and 1–7 against J-774A.1 cultured cells was evaluated. Compound 5 (2-methyl-2-{[(9-oxo-9H-xanthen-2-yl)methyl]sulfanyl}- propanoic acid) was effective in inhibiting chemiluminescence of J-774A.1 cells but most of the other tested compounds stimulated the reaction. FAA and two xanthones with a methoxycarbonyl moeity slightly decreased the generation of nitric oxide at 50 μM. Most of the tested compounds (1–7) showed weak toxicity at concentration of 100 μM.
Keywords: Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity

Share and Cite

MDPI and ACS Style

MARONA, H.; PĘKALA, E.; GUNIA, A.; CZUBA, Z.; SZNELER, E.; SADOWSKI, T.; KRÓL, W. The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells. Sci. Pharm. 2009, 77, 743-754. https://doi.org/10.3797/scipharm.0906-08

AMA Style

MARONA H, PĘKALA E, GUNIA A, CZUBA Z, SZNELER E, SADOWSKI T, KRÓL W. The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells. Scientia Pharmaceutica. 2009; 77(4):743-754. https://doi.org/10.3797/scipharm.0906-08

Chicago/Turabian Style

MARONA, Henryk, Elżbieta PĘKALA, Agnieszka GUNIA, Zenon CZUBA, Edward SZNELER, Tadeusz SADOWSKI, and Wojciech KRÓL. 2009. "The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells" Scientia Pharmaceutica 77, no. 4: 743-754. https://doi.org/10.3797/scipharm.0906-08

APA Style

MARONA, H., PĘKALA, E., GUNIA, A., CZUBA, Z., SZNELER, E., SADOWSKI, T., & KRÓL, W. (2009). The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells. Scientia Pharmaceutica, 77(4), 743-754. https://doi.org/10.3797/scipharm.0906-08

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