Next Article in Journal
Scavenger Activity Evaluation of the Clove Bud Essential Oil (Eugenia caryophyllus) and Eugenol Derivatives Employing ABTS+• Decolorization
Previous Article in Journal
Low Density Lipid Nanoparticles for Solid Tumor Targeting
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 79
Issue 4
10.3797/scipharm.1109-14
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates

by
Danylo KAMINSKYY
1,
Dmytro KHYLUK
1,
Olexandr VASYLENKO
2,
Lucjusz ZAPRUTKO
3 and
Roman LESYK
1,*
1
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
2
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Murmanska 1, 02094, Kyiv, Ukraine
3
Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(4), 763-778; https://doi.org/10.3797/scipharm.1109-14
Submission received: 19 September 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
Versions Notes

Abstract

The synthesis and evaluation of the anticancer activity of 3’-aryl-5’-arylidene-spiro[3H-indole-3,2’-thiazolidine]-2,4’(1H)-diones and spiro[3H-indole-3,2’-thi-azolidine]-2,4’(1H)-dione-3’-alkanoic acid esters were described. The structure of the compounds was determined by 1H and 13C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.
Keywords: Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine] Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine]

Share and Cite

MDPI and ACS Style

KAMINSKYY, D.; KHYLUK, D.; VASYLENKO, O.; ZAPRUTKO, L.; LESYK, R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Sci. Pharm. 2011, 79, 763-778. https://doi.org/10.3797/scipharm.1109-14

AMA Style

KAMINSKYY D, KHYLUK D, VASYLENKO O, ZAPRUTKO L, LESYK R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Scientia Pharmaceutica. 2011; 79(4):763-778. https://doi.org/10.3797/scipharm.1109-14

Chicago/Turabian Style

KAMINSKYY, Danylo, Dmytro KHYLUK, Olexandr VASYLENKO, Lucjusz ZAPRUTKO, and Roman LESYK. 2011. "A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates" Scientia Pharmaceutica 79, no. 4: 763-778. https://doi.org/10.3797/scipharm.1109-14

APA Style

KAMINSKYY, D., KHYLUK, D., VASYLENKO, O., ZAPRUTKO, L., & LESYK, R. (2011). A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Scientia Pharmaceutica, 79(4), 763-778. https://doi.org/10.3797/scipharm.1109-14

Article Metrics

Back to TopTop