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Volume 81
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Article

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

by
Nazariy POKHODYLO
*,
Olga SHYYKA
and
Vasyl MATIYCHUK
Ivan Franko National University of Lviv, Kyryla & Mefodiya Str., 6, 79005 Lviv, Ukraine
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(3), 663-676; https://doi.org/10.3797/scipharm.1302-04
Submission received: 8 February 2013 / Accepted: 14 April 2013 / Published: 14 April 2013
Versions Notes

Abstract

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI50 level.
Keywords: 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis

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MDPI and ACS Style

POKHODYLO, N.; SHYYKA, O.; MATIYCHUK, V. Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity. Sci. Pharm. 2013, 81, 663-676. https://doi.org/10.3797/scipharm.1302-04

AMA Style

POKHODYLO N, SHYYKA O, MATIYCHUK V. Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity. Scientia Pharmaceutica. 2013; 81(3):663-676. https://doi.org/10.3797/scipharm.1302-04

Chicago/Turabian Style

POKHODYLO, Nazariy, Olga SHYYKA, and Vasyl MATIYCHUK. 2013. "Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity" Scientia Pharmaceutica 81, no. 3: 663-676. https://doi.org/10.3797/scipharm.1302-04

APA Style

POKHODYLO, N., SHYYKA, O., & MATIYCHUK, V. (2013). Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity. Scientia Pharmaceutica, 81(3), 663-676. https://doi.org/10.3797/scipharm.1302-04

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