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Volume 81
Issue 3
10.3797/scipharm.1206-02
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Cytotoxic Compounds from Brucea mollis

by
Mai Hung Thanh TUNG
1,
Ho Viet ĐUC
1,
Tran Thu HUONG
1,
Nguyen Thanh DUONG
1,
Do Thi PHUONG
2,
Do Thi THAO
2,
Bui Huu TAI
3,
Young Ho KIM
3,
Tran The BACH
4 and
Nguyen Manh CUONG
1,*
1
Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
2
Institute of Bioscience and Biotechnology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
3
College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea
4
Institute of Ecology and Biological Resources, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(3), 819-832; https://doi.org/10.3797/scipharm.1206-02
Submission received: 3 June 2012 / Accepted: 31 December 2012 / Published: 29 September 2016
Versions Notes

Abstract

Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1–4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.
Keywords: Brucea mollis; Cytotoxicity; Quassinoids; Alkaloids; Triterpenoids Brucea mollis; Cytotoxicity; Quassinoids; Alkaloids; Triterpenoids

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MDPI and ACS Style

TUNG, M.H.T.; ĐUC, H.V.; HUONG, T.T.; DUONG, N.T.; PHUONG, D.T.; THAO, D.T.; TAI, B.H.; KIM, Y.H.; BACH, T.T.; CUONG, N.M. Cytotoxic Compounds from Brucea mollis. Sci. Pharm. 2013, 81, 819-832. https://doi.org/10.3797/scipharm.1206-02

AMA Style

TUNG MHT, ĐUC HV, HUONG TT, DUONG NT, PHUONG DT, THAO DT, TAI BH, KIM YH, BACH TT, CUONG NM. Cytotoxic Compounds from Brucea mollis. Scientia Pharmaceutica. 2013; 81(3):819-832. https://doi.org/10.3797/scipharm.1206-02

Chicago/Turabian Style

TUNG, Mai Hung Thanh, Ho Viet ĐUC, Tran Thu HUONG, Nguyen Thanh DUONG, Do Thi PHUONG, Do Thi THAO, Bui Huu TAI, Young Ho KIM, Tran The BACH, and Nguyen Manh CUONG. 2013. "Cytotoxic Compounds from Brucea mollis" Scientia Pharmaceutica 81, no. 3: 819-832. https://doi.org/10.3797/scipharm.1206-02

APA Style

TUNG, M. H. T., ĐUC, H. V., HUONG, T. T., DUONG, N. T., PHUONG, D. T., THAO, D. T., TAI, B. H., KIM, Y. H., BACH, T. T., & CUONG, N. M. (2013). Cytotoxic Compounds from Brucea mollis. Scientia Pharmaceutica, 81(3), 819-832. https://doi.org/10.3797/scipharm.1206-02

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