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Biomolecules
Volume 15
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10.3390/biom15020210
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

by
Zhijiang Deng
1,2,3,†,
Jieming Li
1,2,3,*,†,
Pengbo Zhu
1,2,4,
Jie Wang
1,2,3,
Yuanfang Kong
2,3,4,
Yulong Hu
1,2,3,
Juntao Cai
1,2,3 and
Chunhong Dong
1,2,3,*
1
Traditional Chinese Medicine (Zhong Jing) School, Henan University of Chinese Medicine, Zhengzhou 450046, China
2
Henan Polysaccharide Research Center, Zhengzhou 450046, China
3
Henan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou 450046, China
4
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2025, 15(2), 210; https://doi.org/10.3390/biom15020210
Submission received: 6 January 2025 / Revised: 26 January 2025 / Accepted: 29 January 2025 / Published: 1 February 2025
(This article belongs to the Section Natural and Bio-derived Molecules)
Review Reports Versions Notes

Abstract

Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs. Given the rising cancer incidence, there is a critical need for new anticancer agents, and quinazolinones show promising potential in this domain. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, the structure–activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives, to help in the development of new quinazoline and quinazolinone derivatives.
Keywords: quinazolinones; catalytic synthesis; anticancer; mechanisms quinazolinones; catalytic synthesis; anticancer; mechanisms

Share and Cite

MDPI and ACS Style

Deng, Z.; Li, J.; Zhu, P.; Wang, J.; Kong, Y.; Hu, Y.; Cai, J.; Dong, C. Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms. Biomolecules 2025, 15, 210. https://doi.org/10.3390/biom15020210

AMA Style

Deng Z, Li J, Zhu P, Wang J, Kong Y, Hu Y, Cai J, Dong C. Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms. Biomolecules. 2025; 15(2):210. https://doi.org/10.3390/biom15020210

Chicago/Turabian Style

Deng, Zhijiang, Jieming Li, Pengbo Zhu, Jie Wang, Yuanfang Kong, Yulong Hu, Juntao Cai, and Chunhong Dong. 2025. "Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms" Biomolecules 15, no. 2: 210. https://doi.org/10.3390/biom15020210

APA Style

Deng, Z., Li, J., Zhu, P., Wang, J., Kong, Y., Hu, Y., Cai, J., & Dong, C. (2025). Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms. Biomolecules, 15(2), 210. https://doi.org/10.3390/biom15020210

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