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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits

by
Rabiea Ashowen Ahmoda
1,
Andrea Pirković
2,
Violeta Milutinović
3,
Milena Milošević
4,
Aleksandar Marinković
1 and
Aleksandra A. Jovanović
2,*
1
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia
2
Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, Zemun, 11080 Belgrade, Serbia
3
Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia
4
Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Plants 2025, 14(3), 352; https://doi.org/10.3390/plants14030352
Submission received: 25 December 2024 / Revised: 21 January 2025 / Accepted: 22 January 2025 / Published: 24 January 2025
Versions Notes

Abstract

Fumaria officinalis (fumitory), in the form of dust, was employed as a source of bioactive extracts whose chemical profile and biological potential were investigated. According to the results of the optimization of the extraction protocol, the extract with the highest polyphenol yield was prepared using fumitory dust under the optimal conditions determined using the statistical tool, 23 full factorial design: 50% ethanol and a 30:1 mL/g ratio during 120 s of microwave extraction (22.56 mg gallic acid equivalent/g of plant material). LC-MS and spectrophotometric/gravimetric analyses quantified the polyphenol, flavonoid, tannin, alkaloid, and protein contents. Caffeoylmalic acid, quercetin dihexoside, quercetin pentoside hexoside, rutin, and methylquercetin dihexoside were the most dominant compounds. The highest total flavonoid, condensed tannin, alkaloid, and protein yields were determined in the extract prepared using microwaves. In addition to the proven antioxidant potential, in the present study, the anti-inflammatory activity of fumitory extracts is also proven in the keratinocyte model, as well as a significant reduction of H2O2-induced reactive oxygen species production in cells and the absence of keratinocyte cytotoxicity. Thus, detailed chemical profiles and investigated biological effects related to skin health benefits encourage the potential application of fumitory dust extracts in dermo-cosmetic and pharmaceutical preparations for dermatological circumstances.
Keywords: alkaloids; bioactives; extraction; Fumaria officinalis; optimization; plant dust; polyphenols alkaloids; bioactives; extraction; Fumaria officinalis; optimization; plant dust; polyphenols

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MDPI and ACS Style

Ahmoda, R.A.; Pirković, A.; Milutinović, V.; Milošević, M.; Marinković, A.; Jovanović, A.A. Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits. Plants 2025, 14, 352. https://doi.org/10.3390/plants14030352

AMA Style

Ahmoda RA, Pirković A, Milutinović V, Milošević M, Marinković A, Jovanović AA. Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits. Plants. 2025; 14(3):352. https://doi.org/10.3390/plants14030352

Chicago/Turabian Style

Ahmoda, Rabiea Ashowen, Andrea Pirković, Violeta Milutinović, Milena Milošević, Aleksandar Marinković, and Aleksandra A. Jovanović. 2025. "Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits" Plants 14, no. 3: 352. https://doi.org/10.3390/plants14030352

APA Style

Ahmoda, R. A., Pirković, A., Milutinović, V., Milošević, M., Marinković, A., & Jovanović, A. A. (2025). Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits. Plants, 14(3), 352. https://doi.org/10.3390/plants14030352

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