Next Article in Journal
Burnout and Doctors: Prevalence, Prevention and Intervention
Previous Article in Journal
Understanding the Needs of Young Women Regarding Breast Cancer Risk Assessment and Genetic Testing: Convergence and Divergence among Patient-Counselor Perceptions and the Promise of Peer Support
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Healthcare
Volume 4
Issue 3
10.3390/healthcare4030036
healthcare-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Barriers and Strategies in Guideline Implementation—A Scoping Review

by
Florian Fischer
1,*,
Kerstin Lange
1,
Kristina Klose
2,
Wolfgang Greiner
2 and
Alexander Kraemer
1
1
Department of Public Health Medicine, School of Public Health, Bielefeld University, 33615 Bielefeld, Germany
2
Department of Health Care Management, School of Public Health, Bielefeld University, 33615 Bielefeld, Germany
*
Author to whom correspondence should be addressed.
Healthcare 2016, 4(3), 36; https://doi.org/10.3390/healthcare4030036
Submission received: 28 April 2016 / Revised: 20 June 2016 / Accepted: 24 June 2016 / Published: 29 June 2016
Browse Figures
Versions Notes

Abstract

:
Research indicates that clinical guidelines are often not applied. The success of their implementation depends on the consideration of a variety of barriers and the use of adequate strategies to overcome them. Therefore, this scoping review aims to describe and categorize the most important barriers to guideline implementation. Furthermore, it provides an overview of different kinds of suitable strategies that are tailored to overcome these barriers. The search algorithm led to the identification of 1659 articles in PubMed. Overall, 69 articles were included in the data synthesis. The content of these articles was analysed by using a qualitative synthesis approach, to extract the most important information on barriers and strategies. The barriers to guideline implementation can be differentiated into personal factors, guideline-related factors, and external factors. The scoping review revealed the following aspects as central elements of successful strategies for guideline implementation: dissemination, education and training, social interaction, decision support systems and standing orders. Available evidence indicates that a structured implementation can improve adherence to guidelines. Therefore, the barriers to guideline implementation and adherence need to be analysed in advance so that strategies that are tailored to the specific setting and target groups can be developed.

1. Introduction

Clinical practice guidelines (hereafter referred to as guidelines) can be defined as “systematically developed statements to assist practitioners’ decisions about appropriate health care for specific clinical circumstances” [1]. Therefore, guidelines are considered to decrease the gap between research and current practice and, thus, to reduce inappropriate variability in practice [2]. Guidelines are valuable tools in situations where the scientific evidence is sparse, where multiple therapies are available, or where uncertainty in terms of treatment options exists. The development and implementation of guidelines is intended to organize and provide the best available evidence to support clinical decision making in order to improve quality of care, patient outcomes and cost effectiveness [3,4]. The criteria and prerequisites for developing guidelines are: a highly prevalent disease or frequently used medical procedure, high associated costs and current variations in practice. They are particularly important for diseases leading to premature mortality, avoidable morbidity or negative effects on health-related quality of life. Furthermore, the evidence should indicate that medical care can make a difference to outcomes [5].
Guidelines may be used to translate medical research and expert opinions into recommendations for the daily practical work of health professionals [6]. Despite the growing number of guidelines, their use in practice is frequently reported as being unpredictable, often slow and complex [6,7,8]. Research indicates that guidelines are often not applied. This does not include specific and justified actions in single cases to treat in ways other than those described in the guidelines for the sake of patients, but non-adherence to guidelines may lead to unnecessary diagnostics and suboptimal or even inadequate treatment [9]. It is estimated that about 30%–40% of patients receive treatment that is not based on scientific evidence, and 20%–25% receive treatments that are either not needed or potentially harmful [6,10,11]. Therefore, more research on the implementation of guidelines is needed to promote the systematic translation of current research evidence into routine practice [12]. A successful introduction of guidelines involves the three steps of development, dissemination and implementation [13]. During the past few years, it has become obvious that the development of a guideline does not necessarily lead to changes in clinical practice. Therefore, the focus of management and research in this area has changed from the development to the implementation of guidelines. For example, the latest guidelines have a stronger focus on patient-relevant outcomes and patient involvement during their development, and contain summaries and patient versions to support the implementation process. Nevertheless, knowledge regarding appropriate strategies to implement guidelines remains sparse and no implementation strategy has been identified that is effective in all circumstances [14].
Implementation strategies have to be based on current knowledge about potentially effective interventions and upon an assessment of potential barriers to guideline adoption [10,15,16,17,18,19,20]. The identification of barriers may subsequently lead to the development of tailored implementation strategies. Nevertheless, evidence regarding the most suitable way to translate the identified barriers into tailored interventions is missing [20]. The implementation of guidelines is a complex process that is hampered by several barriers [21,22,23,24]. A systematic review by Cabana and colleagues of barriers to physician adherence to guidelines that included 76 studies identified a large number of different barriers. The authors developed a framework in which these barriers were classified into three main categories: barriers related to physicians’ knowledge (e.g., lack of awareness and lack of familiarity), barriers that affect physicians’ attitudes (e.g., lack of agreement and lack of motivation) and external barriers (e.g., patient-, guideline- and environment-related factors) [22].
The success of any implementation depends on the consideration of a variety of barriers and the use of adequate strategies to overcome them. Therefore, this study aims to describe and categorize the most important barriers to guideline implementation identified by a scoping review. Since the systematic literature review by Cabana and colleagues was published back in 1999, an update is needed which takes the current situation into account. Until now, studies have been divided between barriers and implementation strategies and have focused on only one aspect. To our knowledge, this is the first study to provide an overview of different kinds of suitable strategies that are directly related to the underlying barriers. This study should provide information on barriers and the strategies that are needed to promote the effective implementation and incorporation of guidelines into practice.

2. Materials and Methods

A scoping review was conducted in PubMed according to the procedure and requirements described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [25]. This type of review was chosen because the area of interest is complex. By conducting a scoping review, we aimed to comprehensively identify and describe both barriers to and strategies for guideline implementation. A filter was used to restrict the search to the English and German languages. All articles listed in PubMed and published up until the end of 2015 were considered. The evolved search algorithm focused on several search terms mentioned in the title and abstract. To narrow the search results, synonyms for “guideline” were combined with the search terms “implementation”, “barriers or strategies” and further search terms that indicate aspects of “compliance, acceptance, conformity, approval or adherence”. Therefore, the following search algorithm was used:
(guideline*[Title/Abstract] OR guidance*[Title/Abstract] OR clinical protocol*[Title/Abstract]) AND (strateg*[Title/Abstract] OR barrier*[Title/Abstract]) AND implement*[Title/Abstract] AND (compliance[Title/Abstract] OR accept*[Title/Abstract] OR conform*[Title/Abstract] OR approv*[Title/Abstract] OR adherence[Title/Abstract]) 
This search algorithm led to the identification of 1659 articles. After screening of title and abstract, 1512 of these articles were excluded because they did not fit the study’s objective. Therefore, 146 articles were considered in the screening of full texts. By means of this assessment, 82 were excluded for the following reasons:
  • exclusively disease-specific information on barriers and/or strategies, which do not allow for generalizations (n = 51),
  • no direct reference to barriers or strategies for guideline implementation (n = 38),
  • no clinical guidelines (n = 9),
  • no comparability (e.g., developing countries) (n = 7),
  • study protocol (n = 2).
The number of articles excluded for each criterion is given in brackets. The sum does not add up to 82 because some articles were excluded for multiple reasons. A manual search was conducted through the reference lists of all full texts, which led to the inclusion of five further articles. Finally, 69 articles were included in the qualitative analysis of the scoping review (see Figure 1).
The content of the articles was analysed by using a qualitative synthesis approach, in order to extract the most important information on barriers and strategies. Furthermore, during the process of analysis special attention was given to the link between barriers and adequate strategies.
Studies and reviews were included in the synthesis. If barriers and/or strategies were mentioned, they were included in the framework that we developed as a result of our study. For this reason, no quality appraisal tools were used.

3. Results

Overall, the 69 articles included in the synthesis were composed of 42 studies and 27 reviews or theoretical conceptual papers. Most articles described the situation regarding guideline implementation in a particular country, mainly the Netherlands (n = 15), the United States of America (n = 13), Australia (n = 7) and Germany (n = 6). In 47 articles, barriers or strategies regarding the implementation of disease-specific guidelines were described; 22 articles did not concentrate on a specific disease but described barriers and strategies in general. Overall, 32 articles include information on barriers and 49 describe strategies for guideline implementation. Some articles described both barriers and strategies (n = 12), although they were not always directly linked to each other. Further information on the articles included in the qualitative synthesis is given in Table 1.

3.1. Barriers and Strategies in Guideline Implementation

We have summarised the barriers, interventions and strategies involved in guideline implementation that were mentioned in the chosen articles in Table 2. Single interventions were separated from more complex strategies, which mainly consist of a combination of single interventions or provide a broader perspective on solutions to solve the problems created by barriers to guideline implementation. Only those aspects which are of general importance and not disease- or guideline-specific were included. We distinguished between personal factors, guideline-related factors and external factors, to highlight the different levels upon which strategies may focus.
The barriers mentioned under personal factors are divided into factors related to physicians’ knowledge and attitudes because these two factors are closely linked to any behavioural change and are prerequisites for it [22]. In terms of physicians’ knowledge, the main barriers to implementation and adherence are lack of awareness and lack of familiarity with the guideline and its recommendations [22,33]. When it comes to attitudes, the main barriers are considered to be: lack of agreement, self-efficacy, skills, outcome expectancy and motivation [22,33,49]. In this context, the derived strategies for guideline implementation mainly focus on dissemination strategies and educational aspects. In particular, active learning from experts as opinion leaders [14,23,28,71,85] and continuing education [20,28], e.g., by continuous medical education (CME) [82,86], were emphasized as useful tools for improving physicians’ knowledge. Regarding the improvement of physicians’ attitudes, (individualized) audit and feedback are considered to be effective strategies [32,36,43,49].
The main barriers connected with guideline-related factors are linked to the process of developing and establishing a guideline. In particular, evidence and the plausibility of recommendations are important factors during the development phase. Furthermore, the complexity [27,43,50], layout [57], accessibility [45] and applicability [53] have to be considered. Therefore, the guidelines should be as short and user-friendly as possible [86] to reduce complexity [27,43,50,53]. Checklists [84] and further tools, such as the inclusion of tablets, smartphones and mobiles as platforms for the dissemination of guidelines [62] and the implementation of decision support systems [30,57], were mentioned as suitable strategies to improve accessibility. The quality of a guideline, which is associated with its usage, may also depend upon the consideration of comorbidity and multimorbidity within its recommendations. Clear intervention goals must be set [23].
External factors may also confer several advantages during the implementation process of a guideline. Among the barriers related to external factors, organizational constraints are of major importance. Therefore, improvements in the organization of care are necessary, which may be promoted by the standardization of processes and procedures [87] and the development of protocols [57]. In addition, the care setting has to be considered during the development of a guideline [46,88] and links to quality management [54] may improve adherence. The barrier of lack of resources, such as time restrictions and heavy workload [35,55,68], can only be overcome by the provision of enough time to utilize the guidelines in practice [31,69], by establishing clear roles in terms of standing orders [31] and by providing financial incentives [42,54]. A multiprofessional collaboration with other healthcare professionals may foster implementation and adherence to guidelines [20,56]. The local context must also be considered to allow for the local adaptation of guidelines [23,50,61]. Furthermore, local consensus groups may change social norms and, therefore, improve guideline implementation [85].

3.2. Categorization of Implementation Strategies

The description of the barriers related to guideline implementation highlights the fact that hindrances to the adoption of and adherence to guidelines exist at different levels. Therefore, both the general and context-specific barriers have to be assessed and analysed to allow for the development of tailored implementation strategies [29,50,57]. Furthermore, the patient perspective needs to be recognized [36,41]. An overview of several barriers is provided in Table 2, but many more barriers related to the content of guidelines or the medical disciplines are conceivable and should be considered during a structured implementation process.
Strategies for guideline implementation can be broadly classified as workflow- or provider-focused. Workflow-focused strategies seek to minimize contextual barriers and promote changes that facilitate the adoption of guidelines (e.g., clinical reminders). Provider-focused strategies seek to minimize provider-level barriers and to create provider-level facilitators to guideline adherence. This can be achieved by the use of communication strategies to raise awareness about guidelines. These two types of strategy are complementary. Therefore, the effective implementation of guidelines requires a combination of workflow- and provider-focused strategies [42]. It follows that a multifaceted implementation with a balanced mix between the two types of strategy is more likely to lead to guideline adherence [23,42,86]. In addition, several strategies identified and categorized during the review process contain both workflow- and provider-focused interventions.
The review revealed the following aspects as central elements of successful strategies for guideline implementation. One major factor in the process is the aspect of dissemination. Therefore, the supply of educational materials (including written materials, didactic presentations and interactive conferences) is absolutely essential to raise awareness and increase familiarity and agreement with a guideline and its recommendations [30,43,46,54]. Furthermore, continuous efforts in the education and training of health professionals are needed. This may be done by educational meetings and educational outreach visits [30], audit and feedback [36,37,43,49], workshops [50,89] and small-group interactive postgraduate training sessions [50]. Social interaction is mentioned as a highly relevant factor in guideline implementation. This interaction may include educational outreach visits and marketing [32]. In this context, local opinion leaders are capable of improving evidence-based practice because they may enable guideline developers to meet with the key staff at each organization [28,71]. It must be highlighted that the role of an opinion leader is not equivalent to a physician champion. Opinion leaders are often the first to know about guidelines and to adopt them into their daily clinical practice. In contrast, physician champions might be opinion leaders, but instead of exerting an informal influence, they actively participate in designing and implementing improvement, e.g., by promoting guideline adherence [39]. Two further strategies are workflow focused. Firstly, decision support systems (manual or automated) and reminders will prompt health professionals to perform clinical actions according to the current state of evidence [30]. Secondly, standing orders and standardized documentation are strategies to facilitate guideline adherence [32].

4. Discussion

The absorption of guideline recommendations into everyday practice requires changes in the attitudes and behaviour of health professionals and a certain adaptation of the structural environment [1,6,22,26]. Although behaviour can modify even in the absence of changes in knowledge and attitude, behavioural modifications based on such changes are more permanent [24]. All the barriers described in this article—both internal and external—may influence the knowledge, attitudes or behaviour of health professionals [33]. According to the “Knowledge-Attitude- Behaviour Framework”, physicians have to be aware of a guideline and need to have some knowledge of its content. Afterwards, knowledge influences attitudes, and attitudes affect practice behaviour [90]. Therefore, implementation strategies should be focused on the improvement of knowledge and attitudes in order to improve the uptake of guidelines in clinical practice [4] (see Figure 2).
In order for strategies that promote guideline implementation and adherence to be developed, the barriers have to be assessed and addressed. If interventions and implementation strategies are tailored to specific settings and target groups, behaviour change is more likely [16,29,88]. In this review, we have distinguished between personal factors, guideline-related factors and external factors. In further articles other differentiations were used. For example, a review by Baiardini et al. [24] distinguished between factors which are guideline related (e.g., level of evidence, plausibility, trialability), context dependent (e.g., social norms, organizational characteristics) or directly connected to implementation (e.g., communication and educational strategies). A qualitative study of perceived facilitators and barriers to guideline implementation in psychiatry highlighted the categories of organizational resources (e.g., staff, leadership and dissemination), healthcare professionals’ individual characteristics (knowledge, attitudes and beliefs) and the perception of guidelines and implementation strategies (credibility of content and awareness) [23]. Despite differences in the classification of barriers, successful implementation strategies need to address them all [4,10,22].
Since guidelines are not self-implementing, a step-by-step and planned introduction is needed [16]. Zwerver et al. [17] describe the intervention mapping process for guideline implementation, which was originally developed by Bartholomew et al. [18]. According to this plan, six basic steps must be performed during the process of guideline implementation. The first step is a needs assessment, which aims to identify the target group and stakeholders. In the second step, programme objectives are defined, in which the expected changes in behaviour and environment are stated. To achieve these changes, theory-based methods and practical strategies have to be selected in a third step. After this, step four is the creation of a programme plan, which includes the overall structure and themes of implementation as well as the development and testing of programme materials. The fifth step consists of the actual adoption and implementation of the guideline, which is evaluated in the sixth step [17].
A broad range of guideline implementation strategies with different effects has been described [87]. According to Grol and Grimshaw [10], “none of the approaches is superior for all changes in all situations; we probably need them all”. It is concluded that no single type of intervention is likely to be successful and, therefore, implementation efforts should use a combined approach of strategies tailored to the setting [46].
Evidence indicates that multifaceted implementation strategies are most effective [80,91,92], although Grimshaw et al. [93] argued that multifaceted strategies are not necessarily more effective than single interventions. The current recommendation to promote guideline adherence is to support guidelines by active and multifaceted implementation strategies [9], although the relative efficacy of each component within the multifaceted approach still remains unclear [14,43]. In addition to active implementation strategies, passive dissemination of guidelines should not be disregarded because it offers a cheaper and more feasible approach that may still be effective [94].
Although active implementation strategies have been effective in changing health professionals’ knowledge and practice, some studies have reported only moderate effects [71]. For example, absolute risk differences of 6% (95% CI: 1.8–15.9) for increasing use of endorsed professional practices with a continuing education intervention [95] and 12% (95% CI: 6.0–14.5) with the use of local opinion leaders [96] were reported in Cochrane systematic reviews. Nevertheless, it must be mentioned that the effectiveness in changing health professionals’ knowledge and practice varies both within and between studies. The results of these reviews are based on heterogeneous studies because the types of intervention, setting and outcomes differ [89,96]. Therefore, the setting and barriers need to be considered. Because guideline implementation and adherence do not happen immediately, but may take several years to complete, special attention must be given to the design of evaluation studies in the future [23]. This emphasizes the need for further research that will facilitate reliable and valid conclusions regarding the effectiveness of guideline implementation strategies [31].

Limitations

This scoping review used a systematic approach to identify articles dealing with barriers and/or strategies for guideline implementation. It was conducted only in PubMed by using a comparatively narrow search algorithm. A broader search may lead to the identification of further articles. Nevertheless, we aimed to extract the barriers and strategies described in these articles to provide an overview of the topic.
Another major advantage of the process of summarizing suitable strategies for guideline implementation lies in the fact that there is only a limited evidence base describing the effects of single interventions, strategies or multifaceted approaches. Therefore, the attribution of strategies to barriers is based on aspects described or considered in the literature, although not all aspects are as yet based on the results of empirical research.
Furthermore, we excluded articles and aspects that are based on guideline- or disease-specific factors and focused on barriers and strategies that are more generalizable. Nevertheless, it is clear that, in the process of developing and implementing a guideline, the specific circumstances must be considered.

5. Conclusions

The development and implementation of guidelines is intended to improve the quality of care and to promote patient safety, by presenting the current evidence base and translating it into clinical practice. The publication and dissemination of guidelines does not, on its own, automatically result in their use. Therefore, some kind of implementation is needed. Until now, evidence on the effectiveness of different implementation strategies has been sparse. Nevertheless, the existing evidence indicates that a structured implementation can improve adherence to guidelines [10]. The barriers to guideline implementation and adherence in any particular case need to be analysed in advance so that strategies that are tailored to the specific setting and target groups can be developed. The strategy should include different types of interventions, and it should address physicians’ knowledge and attitudes in order to be effective in changing their behaviour. In considering these aspects, stakeholders must be included in order to reveal barriers and to develop adequate strategies for guideline implementation.

Acknowledgments

The work was supported by Bielefeld University. We acknowledge support of the publication fee by Deutsche Forschungsgemeinschaft and the Open Access Publication Funds of Bielefeld University.

Author Contributions

Florian Fischer and Kristina Klose conceptualized the study design. Kerstin Lange and Florian Fischer conducted the review. Florian Fischer drafted the manuscript. Kerstin Lange, Kristina Klose, Wolfgang Greiner and Alexander Kraemer revised the manuscript critically for important intellectual content. All authors approved the published version.

Conflicts of Interest

The authors declare no conflict of interest.

Abbreviations

The following abbreviations are used in this manuscript:
CIConfidence Interval
CMEContinuous Medical Education
PRISMAPreferred Reporting Items for Systematic Reviews and Meta-Analyses
USAUnited States of America

References

  1. Field, M.; Lohr, K.N. Guidelines for Clinical Practice: From Development to Use; National Academy Press: Washington, DC, USA, 1992. [Google Scholar]
  2. Gundersen, L. The effect of clinical practice guidelines on variations in care. Ann. Intern. Med. 2000, 133, 317–318. [Google Scholar] [CrossRef] [PubMed]
  3. Alderman, M.H.; Furberg, C.D.; Kostis, J.B.; Laragh, J.H.; Psaty, B.M.; Ruilope, L.M.; Volpe, M.; Jackson, R. Hypertension guidelines: Criteria that might make them more clinically useful. Am. J. Hypertens. 2002, 15, 917–923. [Google Scholar] [CrossRef]
  4. Van Dulmen, S.A.; Maas, M.; Staal, J.B.; Rutten, G.; Kiers, H.; Nijhuis-van der Sanden, M.; van der Wees, P. Effectiveness of peer assessment for implementing a dutch physical therapy low back pain guideline: A cluster randomized controlled trial. Phys. Ther. 2014, 94, 1396–1409. [Google Scholar] [CrossRef] [PubMed]
  5. Eccles, M.P.; Grimshaw, J.M.; Shekelle, P.; Schünemann, H.J.; Woolf, S. Developing clinical practice guidelines: Target audiences, identifying topics for guidelines, guideline group composition and functioning and conflicts of interest. Implement. Sci. 2012. [Google Scholar] [CrossRef] [PubMed]
  6. Grol, R. Successes and failures in the implementation of evidence-based guidelines for clinical practice. Med. Care 2001, 39, II46–II54. [Google Scholar] [CrossRef] [PubMed]
  7. Sheldon, T.A.; Cullum, N.; Dawson, D.; Lankshear, A.; Lowson, K.; Watt, I.; West, P.; Wright, D.; Wright, J. What’s the evidence that nice guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients’ notes, and interviews. BMJ 2004. [Google Scholar] [CrossRef] [PubMed]
  8. Rycroft-Malone, J.; Seers, K.; Crichton, N.; Chandler, J.; Hawkes, C.A.; Allen, C.; Bullock, I.; Strunin, L. A pragmatic cluster randomised trial evaluating three implementation interventions. Implement. Sci. 2012. [Google Scholar] [CrossRef]
  9. Storm-Versloot, M.N.; Knops, A.M.; Ubbink, D.T.; Goossens, A.; Legemate, D.A.; Vermeulen, H. Long-term adherence to a local guideline on postoperative body temperature measurement: Mixed methods analysis. J. Eval. Clin. Pract. 2012, 18, 841–847. [Google Scholar] [CrossRef] [PubMed]
  10. Grol, R.; Grimshaw, J. From best evidence to best practice: Effective implementation of change in patients’ care. Lancet 2003, 362, 1225–1230. [Google Scholar] [CrossRef]
  11. Doherty, S.R.; Jones, P.D. Use of an ‘evidence-based implementation’ strategy to implement evidence-based care of asthma into rural district hospital emergency departments. Rural Remote Health 2006, 6. [Google Scholar] [PubMed]
  12. Eccles, M.P.; Armstrong, D.; Baker, R.; Cleary, K.; Davies, H.; Davies, S.; Glasziou, P.; Ilott, I.; Kinmonth, A.-L.; Leng, G.; et al. An implementation research agenda. Implement. Sci. 2009. [Google Scholar] [CrossRef] [PubMed]
  13. Forrest, D.; Hoskins, A.; Hussey, R. Clinical guidelines and their implementation. Postgrad. Med. J. 1996, 72, 19–22. [Google Scholar] [CrossRef] [PubMed]
  14. Knops, A.M.; Storm-Versloot, M.N.; Mank, A.P.; Ubbink, D.T.; Vermeulen, H.; Bossuyt, P.M.; Goossens, A. Factors influencing long-term adherence to two previously implemented hospital guidelines. Int. J. Qual. Health Care 2010, 22, 421–429. [Google Scholar] [CrossRef] [PubMed]
  15. Gagliardi, A.R.; Alhabib, S. Trends in guideline implementation: A scoping systematic review. Implement. Sci. 2015. [Google Scholar] [CrossRef] [PubMed]
  16. Grol, R. Beliefs and evidence in changing clinical practice. BMJ 1997, 315, 418–421. [Google Scholar] [CrossRef] [PubMed]
  17. Zwerver, F.; Schellart, A.J.M.; Anema, J.R.; Rammeloo, K.C.; van der Beek, A.J. Intervention mapping for the development of a strategy to implement the insurance medicine guidelines for depression. BMC Public Health 2011. [Google Scholar] [CrossRef] [PubMed]
  18. Bartolomew, L.K.; Parcel, G.S.; Kok, G.; Gottlieb, N.H. Intervention Mapping: Designing Theory and Evidence-Based Health Promotion Programs; Mountain View; McGraw-Hill Humanities/Social Sciences/Languages: Columbus, OH, USA, 2001. [Google Scholar]
  19. Chenot, J.-F.; Scherer, M.; Becker, A.; Donner-Banzhoff, N.; Baum, E.; Leonhardt, C.; Keller, S.; Pfingsten, M.; Hildebrandt, J.; Basler, H.-D.; et al. Acceptance and perceived barriers of implementing a guideline for managing low back in general practice. Implement. Sci. 2008. [Google Scholar] [CrossRef] [PubMed]
  20. Lugtenberg, M.; Zegers-van Schaick, J.M.; Westert, G.P.; Burgers, J.S. Why don’t physicians adhere to guideline recommendations in practice? An analysis of barriers among dutch general practitioners. Implement. Sci. 2009. [Google Scholar] [CrossRef] [PubMed]
  21. Grol, R.; Wensing, M. What drives change? Barriers to and incentives for achieving evidence-based practice. Med. J. Aust. 2004, 180, S57–S60. [Google Scholar] [PubMed]
  22. Cabana, M.D.; Rand, C.S.; Powe, N.R.; Wu, A.W.; Wilson, M.H.; Abboud, P.A.; Rubin, H.R. Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 1999, 282, 1458–1465. [Google Scholar] [CrossRef] [PubMed]
  23. Forsner, T.; Hansson, J.; Brommels, M.; Wistedt, A.A.; Forsell, Y. Implementing clinical guidelines in psychiatry: A qualitative study of perceived facilitators and barriers. BMC Psychiatry 2010. [Google Scholar] [CrossRef] [PubMed]
  24. Baiardini, I.; Braido, F.; Bonini, M.; Compalati, E.; Canonica, G.W. Why do doctors and patients not follow guidelines? Curr. Opin. Allergy Clin. Immunol. 2009, 9, 228–233. [Google Scholar] [CrossRef] [PubMed]
  25. Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. Int. J. Surg. 2010, 8, 336–341. [Google Scholar] [CrossRef] [PubMed]
  26. Albert, U.-S.; Koller, M.; Lorenz, W.; Doherty, J.; Schulz, K.-D.; Wagner, U.; Kopp, I. Implementierung und Evaluation von Leitlinien auf nationaler Ebene: Entwicklung eines Konzeptes für die Stufe-3-Leitlinie “Brustkrebs-Früherkennung in Deutschland”. Z Ärztl. Fortb Qual. 2004, 98, 347–359. [Google Scholar]
  27. Alweis, R.; Greco, M.; Wasser, T.; Wenderoth, S. An initiative to improve adherence to evidence-based guidelines in the treatment of uris, sinusitis, and pharyngitis. J. Community Hosp. Intern. Med. Perspect. 2014. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  28. Bahrami, M.; Deery, C.; Clarkson, J.E.; Pitts, N.B.; Johnston, M.; Ricketts, I.; MacLennan, G.; Nugent, Z.J.; Tilley, C.; Bonetti, D.; et al. Effectiveness of strategies to disseminate and implement clinical guidelines for the management of impacted and unerupted third molars in primary dental care, a cluster randomised controlled trial. Br. Dent. J. 2004, 197, 691–696. [Google Scholar] [CrossRef] [PubMed]
  29. Baker, R.; Reddish, S.; Robertson, N.; Hearnshaw, H.; Jones, B. Randomised controlled trial of tailored strategies to implement guidelines for the management of patients with depression in general practice. Br. J. Gen. Pract. 2001, 51, 737–741. [Google Scholar] [PubMed]
  30. Barosi, G. Strategies for dissemination and implementation of guidelines. Neurol. Sci. 2006, 27, 231–234. [Google Scholar] [CrossRef] [PubMed]
  31. Bekkering, G.E.; Hendriks, H.J.; van Tulder, M.W.; Knol, D.L.; Hoeijenbos, M.; Oostendorp, R.A.; Bouter, L.M. Effect on the process of care of an active strategy to implement clinical guidelines on physiotherapy for low back pain: A cluster randomised controlled trial. Qual. Saf. Health Care 2005, 14, 107–112. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  32. Burns, S.P.; Nelson, A.L.; Bosshart, H.T.; Goetz, L.L.; Harrow, J.J.; Gerhart, K.D.; Bowers, H.; Krasnicka, B.; Guihan, M. Implementation of clinical practice guidelines for prevention of thromboembolism in spinal cord injury. J. Spinal Cord Med. 2005, 28, 33–42. [Google Scholar] [PubMed]
  33. Cabana, M.D.; Flores, G. The role of clinical practice guidelines in enhancing quality and reducing racial/ethnic disparities in paediatrics. Paediatr. Respir. Rev. 2002, 3, 52–58. [Google Scholar] [CrossRef] [PubMed]
  34. Clark, M. Barriers to the implementation of clinical guidelines. J. Tissue Viability 2003, 13, 62–72. [Google Scholar] [CrossRef]
  35. Dijkstra, R.F.; Braspenning, J.C.; Uiters, E.; van Ballegooie, E.; Grol, R.T. Perceived barriers to the implementation of diabetes guidelines in hospitals in the Netherlands. Neth. J. Med. 2000, 56, 80–85. [Google Scholar] [CrossRef]
  36. Doherty, S. Evidence-based implementation of evidence-based guidelines. Int. J. Health Care Qual. Assur. Inc. Leadersh. Health Serv. 2006, 19, 32–41. [Google Scholar] [CrossRef] [PubMed]
  37. Doherty, S.; Jones, P.; Stevens, H.; Davis, L.; Ryan, N.; Treeve, V. ‘Evidence-based implementation’ of paediatric asthma guidelines in a rural emergency department. J. Paediatr. Child Health 2007, 43, 611–616. [Google Scholar] [CrossRef] [PubMed]
  38. Doherty, S.R.; Jones, P.D.; Davis, L.; Ryan, N.J.; Treeve, V. Evidence-based implementation of adult asthma guidelines in the emergency department: A controlled trial. Emerg. Med. Australas. 2007, 19, 31–38. [Google Scholar] [CrossRef] [PubMed]
  39. Eagle, K.A.; Koelling, T.M.; Montoye, C.K. Primer: Implementation of guideline-based programs for coronary care. Nat. Clin. Parct. 2006, 3, 163–171. [Google Scholar] [CrossRef] [PubMed]
  40. Emond, Y.E.; Calsbeek, H.; Teerenstra, S.; Bloo, G.J.; Westert, G.P.; Damen, J.; Wolff, A.P.; Wollersheim, H.C. Improving the implementation of perioperative safety guidelines using a multifaceted intervention approach: Protocol of the improve study, a stepped wedge cluster randomized trial. Implement. Sci. 2015. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  41. Engers, A.J.; Wensing, M.; van Tulder, M.W.; Timmermans, A.; Oostendorp, R.A.B.; Koes, B.W.; Grol, R. Implementation of the dutch low back pain guideline for general practitioners: A cluster randomized controlled trial. Spine 2005, 30, 559–600. [Google Scholar] [CrossRef] [PubMed]
  42. Flanagan, M.E.; Ramanujam, R.; Doebbeling, B.N. The effect of provider- and workflow-focused strategies for guideline implementation on provider acceptance. Implement. Sci. 2009. [Google Scholar] [CrossRef] [PubMed]
  43. Francke, A.L.; Smit, M.C.; Veer, A.J.E.; Mistiaen, P. Factors influencing the implementation of clinical guidelines for health care professionals: A systematic meta-review. BMC Med. Inform. Decis. Mak. 2008. [Google Scholar] [CrossRef] [PubMed]
  44. Goldberg, S.L.; Akard, L.P.; Dugan, M.J.; Faderl, S.; Pecora, A.L. Barriers to physician adherence to evidence-based monitoring guidelines in chronic myelogenous leukemia. J. Oncol. Pract. 2015, 11, e398–e404. [Google Scholar] [CrossRef] [PubMed]
  45. Graham, I.M.; Stewart, M.; Hertog, M.G.L. Factors impeding the implementation of cardiovascular prevention guidelines: Findings from a survey conducted by the European society of cardiology. Eur. J. Cardiovasc. Prev. Rehabil. 2006, 13, 839–845. [Google Scholar] [CrossRef] [PubMed]
  46. Green, L.A.; Wyszewianski, L.; Lowery, J.C.; Kowalski, C.P.; Krein, S.L. An observational study of the effectiveness of practice guideline implementation strategies examined according to physicians’ cognitive styles. Implement. Sci. 2007. [Google Scholar] [CrossRef] [PubMed]
  47. Haagen, E.C.; Nelen, W.L.D.M.; Hermens, R.P.M.G.; Braat, D.D.M.; Grol, R.P.T.M.; Kremer, J.A.M. Barriers to physician adherence to a subfertility guideline. Hum. Reprod. 2005, 20, 3301–3306. [Google Scholar] [CrossRef] [PubMed]
  48. Hakkennes, S.; Dodd, K. Guideline implementation in allied health professions: A systematic review of the literature. Qual. Saf. Health Care 2008, 17, 296–300. [Google Scholar] [CrossRef] [PubMed]
  49. Handler, J.; Lackland, D.T. Translation of hypertension treatment guidelines into practice: A review of implementation. J. Am. Soc. Hypertens. 2011, 5, 197–207. [Google Scholar] [CrossRef] [PubMed]
  50. Harris, M.F.; Lloyd, J.; Litt, J.; van Driel, M.; Mazza, D.; Russell, G.; Smith, J.; Del Mar, C.; Denney-Wilson, E.; Parker, S.; et al. Preventive evidence into practice (PEP) study: Implementation of guidelines to prevent primary vascular disease in general practice protocol for a cluster randomised controlled trial. Implement. Sci. 2013. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  51. Hysong, S.J.; Best, R.G.; Pugh, J.A. Audit and feedback and clinical practice guideline adherence: Making feedback actionable. Implement. Sci. 2006. [Google Scholar] [CrossRef] [PubMed]
  52. Hysong, S.J.; Best, R.G.; Pugh, J.A. Clinical practice guideline implementation strategy patters in Veterans Affairs primary care clinics. Health Serv. Res. 2007, 42, 84–103. [Google Scholar] [CrossRef] [PubMed]
  53. Katz, D.A. Barriers between guidelines and improved patient care: An analysis of AHSPR’s unstable angina clinical practice guideline. Agency for health care policy and research. Health Serv. Res. 1999, 34, 377–389. [Google Scholar] [PubMed]
  54. Kopp, I.B. Perspektiven der Leitlinienentwicklung und -implementation aus der Sicht der AWMF. Z. Rheumatol. 2010, 69, 298–304. (In German) [Google Scholar] [CrossRef] [PubMed]
  55. La Sierra, A.; Zamorano, J.L.; Ruilope, L.M. Application of hypertension guidelines in clinical practice: Implementation of the 2007 ESH/ESC European practice guidelines in Spain. J. Hypertens. 2009, 27, S27–S32. [Google Scholar] [CrossRef] [PubMed]
  56. Lugtenberg, M.; Burgers, J.S.; Zegers-van Schaick, J.M.; Westert, G.P. Guidelines on uncomplicated urinary tract infections are difficult to follow: Perceived barriers and suggested interventions. BMC Fam. Pract. 2010. [Google Scholar] [CrossRef] [PubMed]
  57. Luitjes, S.H.; Wouters, M.G.; Franx, A.; Scheepers, H.C.; Coupe, V.M.; Wollersheim, H.; Steegers, E.A.; Heringa, M.P.; Hermens, R.P.; van Tulder, M.W. Study protocol: Cost effectiveness of two strategies to implement the NVOG guidelines on hypertension in pregnancy: An innovative strategy including a computerised decision support system compared to a common strategy of professional audit and feedback, a randomized controlled trial. Implement. Sci. 2010. [Google Scholar] [CrossRef] [Green Version]
  58. Maue, S.K.; Segal, R.; Kimberlin, C.L.; Lipowski, E.E. Predicting physician guideline compliance: An assessment of motivators and perceived barriers. Am. J. Manag. Care 2004, 10, 383–391. [Google Scholar] [PubMed]
  59. McKinlay, E.; McLeod, D.; Dowell, A.; Marshall, C. Clinical practice guidelines’ development and use in New Zealand: An evolving process. N. Z. Med. J. 2004, 117, U999. [Google Scholar] [PubMed]
  60. Menzies, S.; Duz, J.; Kinch, R. Knowledge transfer at point of care: Investigating new strategies for implementing guideline recommendations. J. Contin. Educ. Health Prof. 2015. [Google Scholar] [CrossRef] [PubMed]
  61. Mourad, S.M.; Hermens, R.P.M.G.; Liefers, J.; Akkermans, R.P.; Zielhuis, G.A.; Adang, E.; Grol, R.P.T.M.; Nelen, W.L.D.M.; Kremer, J.A.M. A multi-faceted strategy to improve the use of national fertility guidelines; a cluster-randomized controlled trial. Hum. Reprod. 2011, 26, 817–826. [Google Scholar] [CrossRef] [PubMed]
  62. Nothacker, M.; Muche-Borowski, C.; Kopp, I.; Selbmann, H.K.; Neugebauer, E.A.M. Leitlinien—Attraktivität, Implementierung und Evaluation. Z. Evid. Fortbild. Qual. Gesundhwes. 2013, 107, 164–169. [Google Scholar] [CrossRef] [PubMed]
  63. Offerhaus, P.; Fleuren, M.; Wensing, M. Guidelines on anaemia: Effect on primary-care midwives in the Netherlands. Midwifery 2005, 21, 204–211. [Google Scholar] [CrossRef] [PubMed]
  64. Ollenschläger, G.; Kirchner, H.; Berenbeck, C.; Thole, H.; Weingart, O.; Sonntag, D.; Fiene, M.; Thomeczek, C. Aktuelle Initiativen zur Realisierung nationaler Leitlinien in Deutschland—Eine Übersicht. Gesundheitswesen 2002, 64, 513–520. (In German) [Google Scholar] [CrossRef] [PubMed]
  65. Perez, X.; Wisnivesky, J.P.; Lurslurchachai, L.; Kleinman, L.C.; Kronish, I.M. Barriers to adherence to COPD guidelines among primary care providers. Respir. Med. 2012, 106, 374–381. [Google Scholar] [CrossRef] [PubMed]
  66. Perria, C.; IMPLEMEG Study Group. Strategies for the introduction and implementation of a guideline for the treatment of type 2 diabetics by general practitioners (GPps) of the Lazio region of Italy (IMPLEMEG study): Protocol for a cluster randomised controlled trial. BMC Health Serv. Res. 2004. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  67. Perria, C.; Mandolini, D.; Guerrera, C.; Jefferson, T.; Billi, P.; Calzini, V.; Fiorillo, A.; Grasso, G.; Leotta, S.; Marrocco, W.; et al. Implementing a guideline for the treatment of type 2 diabetics: Results of a cluster-randomized controlled trial (C-RCT). BMC Health Serv. Res. 2007. [Google Scholar] [CrossRef] [PubMed]
  68. Peters-Klimm, F.; Natanzon, I.; Muller-Tasch, T.; Ludt, S.; Nikendei, C.; Lossnitzer, N.; Szecsenyi, J.; Herzog, W.; Junger, J. Barriers to guideline implementation and educational needs of general practitioners regarding heart failure: A qualitative study. GMS Z. Med. Ausbild. 2012. [Google Scholar] [CrossRef]
  69. Powell, C.V.E. How to implement change in clinical practice. Paediatr. Respir. Rev. 2003, 4, 340–346. [Google Scholar] [CrossRef]
  70. Raaijmakers, L.G.M.; Martens, M.K.; Bagchus, C.; Vries, N.K.; Kremers, S.P.J. Perceptions of dutch health care professionals regarding the care standard for diabetes. BMC Res. Notes 2013. [Google Scholar] [CrossRef] [PubMed]
  71. Rebbeck, T.; Macedo, L.G.; Maher, C.G. Compliance with clinical guidelines for whiplash improved with a targeted implementation strategy: A prospective cohort study. BMC Health Serv. Res. 2013. [Google Scholar] [CrossRef] [PubMed]
  72. Singh, M.; Hynie, M.; Rivera, T.; Macisaac, L.; Gladman, A.; Cheng, A. An evaluation study of the implementation of stroke best practice guidelines using a knowledge transfer team approach. Can. J. Neurosci. Nurs. 2015, 37, 24–33. [Google Scholar] [PubMed]
  73. Sinnema, H.; Franx, G.; Volker, D.; Majo, C.; Terluin, B.; Wensing, M.; van Balkom, A. Randomised controlled trial of tailored interventions to improve the management of anxiety and depressive disorders in primary care. Implement. Sci. 2011. [Google Scholar] [CrossRef] [Green Version]
  74. Slade, S.C.; Kent, P.; Patel, S.; Bucknall, T.; Buchbinder, R. Barriers to primary care clinician adherence to clinical guidelines for the management of low back pain: A systematic review and meta-synthesis of qualitative studies. Clin. J. Pain 2015. [Google Scholar] [CrossRef] [PubMed]
  75. Taba, P.; Rosenthal, M.; Habicht, J.; Tarien, H.; Mathiesen, M.; Hill, S.; Bero, L. Barriers and facilitators to the implementation of clinical practice guidelines: A cross-sectional survey among physicians in estonia. BMC Health Serv. Res. 2012. [Google Scholar] [CrossRef] [PubMed]
  76. Taylor, N.; Lawton, R.; Slater, B.; Foy, R. The demonstration of a theory-based approach to the design of localized patient safety interventions. Implement. Sci. 2013. [Google Scholar] [CrossRef] [PubMed]
  77. Trivedi, M.H.; Kern, J.K.; Marcee, A.; Grannemann, B.; Kleiber, B.; Bettinger, T.; Altshuler, K.Z.; McClelland, A. Development and implementation of computerized clinical guidelines: Barriers and solutions. Methods Inf. Med. 2002, 41, 435–442. [Google Scholar] [PubMed]
  78. Unverzagt, S.; Oemler, M.; Braun, K.; Klement, A. Strategies for guideline implementation in primary care focusing on patients with cardiovascular disease: A systematic review. Fam. Pract. 2014, 31, 247–266. [Google Scholar] [CrossRef] [PubMed]
  79. van den Boogaard, N.M.; Kersten, F.A.; Goddijn, M.; Bossuyt, P.M.; van der Veen, F.; Hompes, P.G.; Hermens, R.P.; Braat, D.D.; Mol, B.W.; Nelen, W.L. Improving the implementation of tailored expectant management in subfertile couples: Protocol for a cluster randomized trial. Implement. Sci. 2013. [Google Scholar] [CrossRef] [PubMed]
  80. Van der Wees, P.J.; Jamtvedt, G.; Rebbeck, T.; Bie, R.A.; Dekker, J.; Hendriks, E.J.M. Multifaceted strategies may increase implementation of physiotherapy clinical guidelines: A systematic review. Aust. J. Physiother. 2008, 54, 233–241. [Google Scholar] [CrossRef]
  81. Van Dijk, M.K.; Verbraak, M.J.; Oosterbaan, D.B.; van Balkom, A.J. Implementing practice guidelines for anxiety disorders in secondary mental health care: A case study. Int. J. Ment. Health Syst. 2012. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  82. Waldorff, F.B.; Almind, G.; Makela, M.; Moller, S.; Waldemar, G. Implementation of a clinical dementia guideline. A controlled study on the effect of a multifaceted strategy. Scand. J. Prim. Health Care 2003, 21, 142–147. [Google Scholar] [CrossRef] [PubMed]
  83. Weening-Verbree, L.; Huisman-de Waal, G.; van Dusseldorp, L.; van Achterberg, T.; Schoonhoven, L. Oral health care in older people in long term care facilities: A systematic review of implementation strategies. Int. J. Nurs. Stud. 2013, 50, 569–582. [Google Scholar] [CrossRef] [PubMed]
  84. Zwerver, F.; Schellart, A.J.M.; Knol, D.L.; Anema, J.R.; van der Beek, A.J. An implementation strategy to improve the guideline adherence of insurance physicians: An experiment in a controlled setting. Implement. Sci. 2011. [Google Scholar] [CrossRef] [PubMed]
  85. Schectman, J.M.; Schroth, W.S.; Verme, D.; Voss, J.D. Randomized controlled trial of education and feedback for implementation of guidelines for acute low back pain. J. Gen. Intern. Med. 2003, 18, 773–780. [Google Scholar] [CrossRef] [PubMed]
  86. Cabana, M.D.; Rushton, J.L.; Rush, A.J. Implementing practice guidelines for depression: Applying a new framework to an old problem. Gen. Hosp. Psychiatry 2002, 24, 35–42. [Google Scholar] [CrossRef]
  87. Lugtenberg, M.; Burgers, J.S.; Westert, G.P. Effects of evidence-based clinical practice guidelines on quality of care: A systematic review. Qual. Saf. Health Care 2009, 18, 385–392. [Google Scholar] [CrossRef] [PubMed]
  88. De Beurs, D.P.; de Groot, M.H.; Keijser, J.; Verwey, B.; Mokkenstorm, J.; Twisk, J.W.R.; van Duijn, E.; van Hemert, A.M.; Verlinde, L.; Spijker, J.; et al. Improving the application of a practice guideline for the assessment and treatment of suicidal behavior by training the full staff of psychiatric departments via an e-learning supported train-the-trainer program: Study protocol for a randomized controlled trial. Trials 2013. [Google Scholar] [CrossRef] [Green Version]
  89. Cote, A.-M.; Durand, M.-J.; Tousignant, M.; Poitras, S. Physiotherapists and use of low back pain guidelines: A qualitative study of the barriers and facilitators. J. Occup. Rehabil. 2009, 19, 94–105. [Google Scholar] [CrossRef] [PubMed]
  90. Welke, K.F.; BootsMiller, B.J.; McCoy, K.D.; Vaughn, T.E.; Ward, M.M.; Flach, S.D.; Peloso, P.M.; Sorofman, B.A.; Tripp-Reimer, T.; Doebbeling, B.N. What factors influence provider knowledge of a congestive heart failure guideline in a national health care system? Am. J. Med. Qual. 2003, 18, 122–127. [Google Scholar] [CrossRef] [PubMed]
  91. Grimshaw, J.M.; Russell, I.T. Effect of clinical guidelines on medical practice: A systematic review of rigorous evaluations. Lancet 1993, 342, 1317–1322. [Google Scholar] [CrossRef]
  92. Grimshaw, J.M.; Eccles, M.P.; Lavis, J.N.; Hill, S.J.; Squires, J.E. Knowledge translation of research findings. Implement. Sci. 2012. [Google Scholar] [CrossRef] [PubMed]
  93. Grimshaw, J.M.; Eccles, M.P. Is evidence-based implementation of evidence-based care possible? Med. J. Aust. 2004, 180, 50–51. [Google Scholar]
  94. Grimshaw, J.M.; Thomas, R.E.; MacLennan, G.; Fraser, C.; Ramsay, C.R.; Vale, L.; Whitty, P.; Eccles, M.P.; Matowe, L.; Shirran, L.; et al. Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol. Assess. 2004, 8, 1–72. [Google Scholar] [CrossRef]
  95. Forsetlund, L.; Bjorndal, A.; Rashidian, A.; Jamtvedt, G.; O’Brien, M.A.; Wolf, F.; Davis, D.; Odgaard-Jensen, J.; Oxman, A.D. Continuing education meetings and workshops: Effects on professional practice and health care outcomes. Cochrane Database Syst. Rev. 2009, 2, CD003030. [Google Scholar] [PubMed]
  96. Flodgren, G.; Parmelli, E.; Doumit, G.; Gattellari, M.; O’Brien, M.A.; Grimshaw, J.; Eccles, M.P. Local opinion leaders: Effects on professional practice and health care outcomes. Cochrane Database Syst. Rev. 2011, 8, CD000125. [Google Scholar] [PubMed]
Healthcare 04 00036 g001 1024
Figure 1. Flow diagram of the review.
Figure 1. Flow diagram of the review.
Healthcare 04 00036 g001
Healthcare 04 00036 g002 1024
Figure 2. Knowledge-Attitude-Behaviour Framework: Barriers and strategies to guideline implementation.
Figure 2. Knowledge-Attitude-Behaviour Framework: Barriers and strategies to guideline implementation.
Healthcare 04 00036 g002
Table
Table 1. Studies included in qualitative synthesis.
Table 1. Studies included in qualitative synthesis.
ReferenceArticle TypeLocationDisease-Specific/Generic
[26]StudyGermanyDisease-specific: Breast cancer
[27]StudyUSADisease-specific: Sinusitis and pharyngitis
[28]StudyScotlandDisease-specific: Dental care
[24]Reviewn/aGeneric
[29]StudyEnglandDisease-specific: Depression
[30]Reviewn/aDisease-specific: Stroke
[31]StudyNetherlandsDisease-specific: Low back pain
[32]StudyUSADisease-specific: Thrombosis
[33]Reviewn/aGeneric
[22]Reviewn/aGeneric
[33]Reviewn/aDisease-specific: Depression
[34]StudyEngland, Scotland, USAGeneric
[35]StudyNetherlandsDisease-specific: Diabetes
[36]StudyAustraliaGeneric
[11]StudyAustraliaDisease-specific: Asthma
[37]StudyAustraliaDisease-specific: Asthma
[38]StudyAustraliaDisease-specific: Asthma
[39]ReviewUSADisease-specific: Coronary care
[40]StudyDenmarkDisease-specific: Peri-operative safety
[41]StudyNetherlandsDisease-specific: Low back pain
[42]StudyUSAGeneric
[13]ReviewEnglandGeneric
[23]StudySwedenDisease-specific: Psychiatry
[43]Reviewn/aGeneric
[15]Reviewn/aGeneric
[44]StudyUSADisease-specific: Leukemia
[45]StudyGermany, England, France, Spain, Italy, PolandDisease-specific: Cardiovascular diseases
[46]StudyUSADisease-specific: Hypertension
[47]StudyNetherlandsDisease-specific: Gynaecology
[48]ReviewUSA, Australia, Netherlands, United KingdomGeneric
[49]Reviewn/aDisease-specific: Hypertension
[50]StudyAustraliaDisease-specific: Vascular diseases
[51]StudyUSAGeneric
[52]StudyUSAGeneric
[53]StudyUSADisease-specific: Angina
[54]ReviewGermanyGeneric
[55]StudySpainDisease-specific: Hypertension
[20]StudyNetherlandsGeneric
[56]StudyNetherlandsDisease-specific: Urinary tract infection
[57]StudyNetherlandsDisease-specific: Gynaecology
[58]StudyUSAGeneric
[59]StudyNew ZealandGeneric
[60]Reviewn/aGeneric
[61]StudyNetherlandsDisease-specific: Gynaecology
[62]ReviewGermanyGeneric
[63]StudyNetherlandsDisease-specific: Anaemia
[64]ReviewGermanyGeneric
[65]StudyUSADisease-specific: COPD
[66]StudyItalyDisease-specific: Diabetes
[67]StudyItalyDisease-specific: Diabetes
[68]ReviewGermanyDisease-specific: Heart failure
[69]Reviewn/aGeneric
[70]StudyNetherlandsDisease-specific: Diabetes
[71]StudyAustraliaDisease-specific: Whiplash
[8]StudyEnglandDisease-specific: Peri-operative fasting
[72]StudyCanadaDisease-specific: Stroke
[73]StudyNetherlandsDisease-specific: Anxiety and depression
[74]Reviewn/aDisease-specific: Low back pain
[75]StudyEstoniaGeneric
[76]StudyUnited KingdomDisease-specific: Tube feeding
[77]Reviewn/aGeneric
[78]Reviewn/aDisease-specific: Cardiovascular diseases
[79]StudyNetherlandsDisease-specific: Gynaecology
[80]Reviewn/aDisease-specific: Physiotherapy
[81]StudyNetherlandsDisease-specific: Anxiety
[82]StudyDenmarkDisease-specific: Dementia
[83]Reviewn/aDisease-specific: Oral health
[17]StudyNetherlandsDisease-specific: Depression
[84]StudyNetherlandsDisease-specific: Depression
n/a: not applicable.
Table
Table 2. Barriers, interventions and strategies in guideline implementation.
Table 2. Barriers, interventions and strategies in guideline implementation.
LevelBarriersInterventionsStrategies
Personal factors (related to physicians’ knowledge and attitudes)Physicians’ knowledgeLack of awarenessIncreased dissemination of guidelineDissemination strategies
  • Standard dissemination (e.g., receiving guideline via e-Mail)
  • Dissemination of training material
Continuing education
Active learning from experts: opinion leaders
Educational meetings
Individualized feedback and group performance audit
Quality circle
Use of mass media to increase awareness
CME
Lack of familiarityMaking guideline available with practical instruments
Educational posters in examination rooms
CME that focuses on specific guideline recommendations
Physicians’ attitudesLack of agreementOpinion leadersEducational meetings
Educational outreach visits
Marketing outreach visits
Identifying opinion leaders
Financial opportunities/penalties
Standing orders
Physician participation in guideline development
Special society endorsement of guideline
Small group education
Lack of self-efficacyCME focusing on skillsDissemination
Educational outreach visits
(individualized) audit and feedback
Interactive learning / group training
Audit and feedback of individual performance: positive individualized feedback during training and subsequently in practice, assistance with questions
Lack of skillsCME focusing on skills
Audit and feedback of individual performance
Lack of learning culturePromoting learning organizations
Lack of outcome expectancyAudit and feedback of practice wide performances
Citation of previous published success at improving outcomes through guideline implementation
Lack of motivationMotivational strategies that utilize audit and feedback
Opinion leaders
Guideline- related factorsLack of evidenceUse of methods of evidence-based medicineUse of methods of evidence-based medicine for guideline development
Communication strategies
Marketing outreach visits
(Computerized) decision support systems
Reminders
Pilot projects
Appraisal of evidence in recommendations
Regular updates
Plausibility of recommendationsShort and user-friendly versions of guidelines
Checklists
Complexity (too theoretical)Simplicity
Design and development of guideline
Poor layout
Access to guidelineProvide easy access to guideline
Decision support systems
Lack of applicabilityUsing tablets, smartphones, and mobiles for provision of guidelines
Focus on patients with single disease entitiesConsideration of comorbidity and multimorbidity in guidelines
Exclusion of patients with complex disease entities
Lack of clear intervention goalsSetting clear intervention goals
TrialabilityPilot projects
External factorsOrganisational constraintsStandardisation of processes and proceduresImprovements in organisation of care
Development of protocols specifically targeting practice assistants
Guideline development needs to consider the care setting
Link to quality management
Lack of resources (time restrictions, heavy workload, facilitation)Financial incentives/compensationStanding orders
Providing time for documentation and utilization of guidelines
Clear roles
External facilitation
Lack of collaborationImproving multiprofessional collaboration with other healthcare professionalsLocal adaptation
Local consensus groups
Incorporation into established structures
Social and clinical normsLocal consensus groups
CME: Continuous Medical Education.

Share and Cite

MDPI and ACS Style

Fischer, F.; Lange, K.; Klose, K.; Greiner, W.; Kraemer, A. Barriers and Strategies in Guideline Implementation—A Scoping Review. Healthcare 2016, 4, 36. https://doi.org/10.3390/healthcare4030036

AMA Style

Fischer F, Lange K, Klose K, Greiner W, Kraemer A. Barriers and Strategies in Guideline Implementation—A Scoping Review. Healthcare. 2016; 4(3):36. https://doi.org/10.3390/healthcare4030036

Chicago/Turabian Style

Fischer, Florian, Kerstin Lange, Kristina Klose, Wolfgang Greiner, and Alexander Kraemer. 2016. "Barriers and Strategies in Guideline Implementation—A Scoping Review" Healthcare 4, no. 3: 36. https://doi.org/10.3390/healthcare4030036

APA Style

Fischer, F., Lange, K., Klose, K., Greiner, W., & Kraemer, A. (2016). Barriers and Strategies in Guideline Implementation—A Scoping Review. Healthcare, 4(3), 36. https://doi.org/10.3390/healthcare4030036

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop