Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer
, Jitka Hausnerová 3, Petra Ovesná 4 and VÃt Weinberger 1,*Round 1
Reviewer 1 Report
Very interesting, high quality article.
Author Response
Thank you very much for reviewing the manuscript. We went though the manuscript once more again very carefully and checked an English language properly.
Reviewer 2 Report
The authors reviewed the total of 264 Endometrial cancer patients (26% asymptomatic, 74% with reported symptoms) to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. They concluded bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final FIGO stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.
Overall, the manuscript is well written. The sample size is a little bit small but still enough to generate significant results. The data presentation is logic and easy to be understood. The result will point out the importance of routinely examination for early detection in clinical practice due to no obvious difference between an asymptomatic and symptomatic group of patients. Add a survival analysis will further improve the quality of the manuscript.
Author Response
Thank you very much for reviewing the manuscript. We went though the manuscript once more again very carefully and checked an English language properly. We plan to continue on that topic in the future. Our aim will be to analyze the difference in survival between symtomatic and asymptomatic endometria cancer patients on the same stage.
