Next Article in Journal
The LKB1–AMPK Signaling Axis Modulates Ferroptosis in Fibroblast-Like Synoviocytes Derived from Rheumatoid Arthritis
Previous Article in Journal
Transimpedance Matrix Measurement (TIM) Parameters Evaluation for the Assessment of Cochlear Implant Electrode Placement and Modiolar Proximity in Children
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 13
Issue 2
10.3390/biomedicines13020320
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Beyond the “Master” Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases

by
Rosa Molfetta
,
Alessia Carnevale
,
Caterina Marangio
,
Erisa Putro
and
Rossella Paolini
*
Department of Molecular Medicine, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(2), 320; https://doi.org/10.3390/biomedicines13020320
Submission received: 20 December 2024 / Revised: 10 January 2025 / Accepted: 27 January 2025 / Published: 29 January 2025
(This article belongs to the Special Issue Mastocytosis, MCAS, and Related Disorders: From Mechanisms to Therapeutic Approaches)
Versions Notes

Abstract

Mast cells (MCs) are essential components of the immune system that enter the circulation as immature bone marrow progenitors and differentiate in peripheral organs under the influence of microenvironment factors. As tissue-resident secretory immune cells, MCs rapidly detect the presence of bacteria and parasites because they harbor many surface receptors, which enable their activation via a multitude of stimuli. MC activation has been traditionally linked to IgE-mediated allergic reactions, but MCs play a pivotal role in different physiological and pathological processes. In gut, MCs are essential for the maintenance of gastrointestinal (GI) barrier function, and their interactions with neurons, immune cells, and epithelial cells have been related to various GI disorders. This review recapitulates intestinal MC roles in diseases with a main focus on inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Emerging therapies targeting MCs and their mediators in clinical practices will also be discussed.
Keywords: intestinal mast cells; homeostasis; gut inflammation intestinal mast cells; homeostasis; gut inflammation

Share and Cite

MDPI and ACS Style

Molfetta, R.; Carnevale, A.; Marangio, C.; Putro, E.; Paolini, R. Beyond the “Master” Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases. Biomedicines 2025, 13, 320. https://doi.org/10.3390/biomedicines13020320

AMA Style

Molfetta R, Carnevale A, Marangio C, Putro E, Paolini R. Beyond the “Master” Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases. Biomedicines. 2025; 13(2):320. https://doi.org/10.3390/biomedicines13020320

Chicago/Turabian Style

Molfetta, Rosa, Alessia Carnevale, Caterina Marangio, Erisa Putro, and Rossella Paolini. 2025. "Beyond the “Master” Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases" Biomedicines 13, no. 2: 320. https://doi.org/10.3390/biomedicines13020320

APA Style

Molfetta, R., Carnevale, A., Marangio, C., Putro, E., & Paolini, R. (2025). Beyond the “Master” Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases. Biomedicines, 13(2), 320. https://doi.org/10.3390/biomedicines13020320

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop