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Article

MWG-UNet: Hybrid Transformer U-Net Model for Brain Tumor Segmentation in MRI Scans++

School of Computer Science and Engineering, Faculty of Information Technology, Macau University of Science and Technology, Macao 999078, China
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Author to whom correspondence should be addressed.
Bioengineering 2025, 12(2), 140; https://doi.org/10.3390/bioengineering12020140 (registering DOI)
Submission received: 2 January 2025 / Revised: 22 January 2025 / Accepted: 27 January 2025 / Published: 31 January 2025

Abstract

The accurate segmentation of brain tumors from medical images is critical for diagnosis and treatment planning. However, traditional segmentation methods struggle with complex tumor shapes and inconsistent image quality which leads to suboptimal results. To address this challenge, we propose multiple tasking Wasserstein Generative Adversarial Network U-shape Network++ (MWG-UNet++) to brain tumor segmentation by integrating a U-Net architecture enhanced with transformer layers which combined with Wasserstein Generative Adversarial Networks (WGAN) for data augmentation. The proposed model called Residual Attention U-shaped Network (RAUNet) for brain tumor segmentation leverages the robust feature extraction capabilities of U-Net and the global context awareness provided by transformers to improve segmentation accuracy. Incorporating WGAN for data augmentation addresses the challenge of limited medical imaging datasets to generate high-quality synthetic images that enhance model training and generalization. Our comprehensive evaluation demonstrates that this hybrid model significantly improves segmentation performance. The RAUNet outperforms compared approaches by capturing long-range dependencies and considering spatial variations. The use of WGANs augments the dataset for resulting in robust training and improved resilience to overfitting. The average evaluation metric for brain tumor segmentation is 0.8965 which outperformed the compared methods.
Keywords: WGAN; brain tumor segmentation; MRI; U-Net; attention mechanism WGAN; brain tumor segmentation; MRI; U-Net; attention mechanism

Share and Cite

MDPI and ACS Style

Lyu, Y.; Tian, X. MWG-UNet: Hybrid Transformer U-Net Model for Brain Tumor Segmentation in MRI Scans++. Bioengineering 2025, 12, 140. https://doi.org/10.3390/bioengineering12020140

AMA Style

Lyu Y, Tian X. MWG-UNet: Hybrid Transformer U-Net Model for Brain Tumor Segmentation in MRI Scans++. Bioengineering. 2025; 12(2):140. https://doi.org/10.3390/bioengineering12020140

Chicago/Turabian Style

Lyu, Yu, and Xiaolin Tian. 2025. "MWG-UNet: Hybrid Transformer U-Net Model for Brain Tumor Segmentation in MRI Scans++" Bioengineering 12, no. 2: 140. https://doi.org/10.3390/bioengineering12020140

APA Style

Lyu, Y., & Tian, X. (2025). MWG-UNet: Hybrid Transformer U-Net Model for Brain Tumor Segmentation in MRI Scans++. Bioengineering, 12(2), 140. https://doi.org/10.3390/bioengineering12020140

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