Sustaining Vaccine Potency in Cold Chain Logistics: Numerical Analysis of Extended Cooling Duration in Glycerol-Infused n-Tetradecane Phase-Change Materials

Vaccination cold chains depend critically on maintaining temperatures within the 2–8 ${}^{\circ }$C range, with phase-change materials (PCMs) like n-tetradecane offering substantial potential due to their high latent heat and optimal melting characteristics. Despite extensive research on PCM melting enhancement, strategies to extend melting duration and thermal stability remain underexplored. This pioneering numerical study investigates the impact of incorporating 5% glycerol additive in n-tetradecane, aiming to decelerate the melting rate and sustain the desired temperature range over prolonged periods. This study numerically assesses the effect of a 5% glycerol additive on n-tetradecane, revealing a substantial 20.6 h extension in safe temperature maintenance, from 123.3 h in pure n-tetradecane (T) to 143.9 h with the additive (T + G). Although T reaches full melting in 121.7 h, the air temperature inside the cold box breaches 8${}^{\circ }$C only 1.6 h after; in contrast, T + G reaches this threshold 2.2 h before full melting, resulting in an effective extension of 20.6 h. Entropy analysis shows a delayed rise in T + G, indicating enhanced thermal stability, while temperature contours confirm T + G sustains cooling until day 6, a full day beyond T. These findings highlight glycerol’s potential to modulate thermal dynamics within PCM-based cold boxes, offering a cost-effective improvement in vaccine transport sustainability.