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Volume 11
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10.22543/2392-7674.1506
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Case Report

The Role of Radiotherapy in the Complex Treatment of Mycosis Fungoides; A Case Report

by
Laura Florentina Rebegea
1,2,3,*,
Claudia Elena Pavel
1,
Nadejda Corobcean
1,
Ana Maria Ilie
1,
Dorel Firescu
4,
Madalin Guliciuc
5,
Elena Niculet
6,
Mihaela Dumitru
1,
Daniela Mihalache
6,
Flavius Bulgaru
4 and
Roxana Andreea Rahnea-Nita
7
1
Department of Radiotherapy, St. Apostol Andrei Emergency Clinical Hospital, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
2
Department of Clinical Medicine, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
3
Research Center in the Field of Medical and Pharmaceutical Sciences, ReFORM-UDJ, Galati, Romania
4
Department of Surgery, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
5
Department of Urology, St. Apostol Andrei Emergency Clinical Hospital, Galati, Romania
6
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
7
Department of Clinical Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2024, 11(1), 249-255; https://doi.org/10.22543/2392-7674.1506
Submission received: 14 January 2024 / Revised: 14 February 2024 / Accepted: 24 February 2024 / Published: 30 April 2024

Abstract

Introduction. Mycosis fungoides (MF) is the most common form of primary cutaneous T-cell lymphoma. Radiotherapy induces excellent response rates in the treatment of localized or extensive lesions of MF, both as monotherapy and as part of a multidisciplinary treatment. Total skin irradiation with electrons or protons is available in a limited number of medical centers and is mainly used in patients with extensive MF. Case presentation. It is presented the case of a 47-year-old patient who developed erythematous papules and plaques on the chest, upper limbs, face and scalp, initially diagnosed as chronic eczema and treated with systemic corticotherapy, antihistamines and dupilumab. Under treatment, the lesions progressed with the appearance of tumorous formations on the scalp and face, some of them ulcerated. Thus, additional (histopathological and immunohistochemical) tests were performed and established the diagnosis of MF. As a result, treatment with methotrexate and narrow-band UVB was initiated, subsequently associated with radiotherapy on the scalp and face lesions (right frontal, right parietal, left oral commissure), 30 Gy to each area. During radiotherapy, the patient developed second grade radiodermatitis associated with radiomucositis, but with a significant reduction in the surface area of the lesions until their disappearance. Conclusions. Radiotherapy can be used in all stages of MF, being useful both for alleviating symptoms and eradicating the disease, meaning that the potential of this form of treatment needs to be further exploited and investigated.
Keywords: mycosis fungoides; radiotherapy; T-cell lymphoma mycosis fungoides; radiotherapy; T-cell lymphoma

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MDPI and ACS Style

Rebegea, L.F.; Pavel, C.E.; Corobcean, N.; Ilie, A.M.; Firescu, D.; Guliciuc, M.; Niculet, E.; Dumitru, M.; Mihalache, D.; Bulgaru, F.; et al. The Role of Radiotherapy in the Complex Treatment of Mycosis Fungoides; A Case Report. J. Mind Med. Sci. 2024, 11, 249-255. https://doi.org/10.22543/2392-7674.1506

AMA Style

Rebegea LF, Pavel CE, Corobcean N, Ilie AM, Firescu D, Guliciuc M, Niculet E, Dumitru M, Mihalache D, Bulgaru F, et al. The Role of Radiotherapy in the Complex Treatment of Mycosis Fungoides; A Case Report. Journal of Mind and Medical Sciences. 2024; 11(1):249-255. https://doi.org/10.22543/2392-7674.1506

Chicago/Turabian Style

Rebegea, Laura Florentina, Claudia Elena Pavel, Nadejda Corobcean, Ana Maria Ilie, Dorel Firescu, Madalin Guliciuc, Elena Niculet, Mihaela Dumitru, Daniela Mihalache, Flavius Bulgaru, and et al. 2024. "The Role of Radiotherapy in the Complex Treatment of Mycosis Fungoides; A Case Report" Journal of Mind and Medical Sciences 11, no. 1: 249-255. https://doi.org/10.22543/2392-7674.1506

APA Style

Rebegea, L. F., Pavel, C. E., Corobcean, N., Ilie, A. M., Firescu, D., Guliciuc, M., Niculet, E., Dumitru, M., Mihalache, D., Bulgaru, F., & Rahnea-Nita, R. A. (2024). The Role of Radiotherapy in the Complex Treatment of Mycosis Fungoides; A Case Report. Journal of Mind and Medical Sciences, 11(1), 249-255. https://doi.org/10.22543/2392-7674.1506

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