Next Article in Journal
Postoperative Pain Management in the Enhanced Recovery After Surgery (ERAS) for Emergency Laparoscopic Cholecystectomy
Previous Article in Journal
Telomeres Are Shorter in Portuguese Obese Adults
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JMMS
Volume 11
Issue 2
10.22543/2392-7674.1528
jmms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Survival Prognostic Factors and Molecular Aspects in Extremity Soft Tissue Sarcoma

by
Bogdan Serban
1,2,*,
Eugen Radu
1,3,
Adrian Cursaru
1,
Bogdan Stefan Cretu
1,2,
Sergiu Andrei Iordache
1,2,
Madalina Cirnu
1,
Cosmin Florentin Niculae
3 and
Cătălin Florin Cîrstoiu
1,2
1
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
Department of Orthopedics and Traumatology, University Emergency Hospital of Bucharest, Bucharest, Romania
3
University Emergency Hospital of Bucharest, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2024, 11(2), 388-395; https://doi.org/10.22543/2392-7674.1528
Submission received: 14 May 2024 / Revised: 14 June 2024 / Accepted: 1 July 2024 / Published: 31 October 2024

Abstract

Soft tissue sarcomas are defined as relatively rare, wide-ranging mesenchymal tumors that present several forms of aggressive behavior. In order to improve the therapeutic result and thus the patient's prognosis, reliable diagnostic and evaluation tools are needed, capable of establishing the evolutive pattern of each patient. Materials and Methods. An analytical observational study was conducted in the period 2016–2023 in the Orthopedics Department of the Bucharest University Emergency Hospital, on patients diagnosed with soft tissue sarcoma. Data such as sex, age, site, size, depth, histotype, grade and margin status, vessel or bone involvement, adenopathies, adjuvant therapy, clinical findings, etc., were analyzed. Diagnosis included immunohistochemistry after macroscopic pathological findings were carefully reviewed by a dedicated pathologist. A molecular study was performed to increase the accuracy of diagnosis, prognosis and clinical management of selected sarcomas. Results. In adult soft tissue sarcomas, histotype has been reported to be a significant predictor of overall survival. In terms of survival rate, vascular invasion appears to be a significant pathological factor for progression in extremity STS. Even though the local control of the disease has improved, the development of systemic metastases seems to be largely influenced by the biological characteristics of the tumor. Conclusions. Significant prognostic factors for the likelihood of a lower survival and death rate are tumor size, tumor depth, histology type, and vascular invasion. The results of the study support and complement the literature data, thus improving the understanding of the prognosis of soft tissue sarcomas.
Keywords: survival; soft tissue sarcomas; molecular aspects; extremity survival; soft tissue sarcomas; molecular aspects; extremity

Share and Cite

MDPI and ACS Style

Serban, B.; Radu, E.; Cursaru, A.; Cretu, B.S.; Iordache, S.A.; Cirnu, M.; Niculae, C.F.; Cîrstoiu, C.F. Survival Prognostic Factors and Molecular Aspects in Extremity Soft Tissue Sarcoma. J. Mind Med. Sci. 2024, 11, 388-395. https://doi.org/10.22543/2392-7674.1528

AMA Style

Serban B, Radu E, Cursaru A, Cretu BS, Iordache SA, Cirnu M, Niculae CF, Cîrstoiu CF. Survival Prognostic Factors and Molecular Aspects in Extremity Soft Tissue Sarcoma. Journal of Mind and Medical Sciences. 2024; 11(2):388-395. https://doi.org/10.22543/2392-7674.1528

Chicago/Turabian Style

Serban, Bogdan, Eugen Radu, Adrian Cursaru, Bogdan Stefan Cretu, Sergiu Andrei Iordache, Madalina Cirnu, Cosmin Florentin Niculae, and Cătălin Florin Cîrstoiu. 2024. "Survival Prognostic Factors and Molecular Aspects in Extremity Soft Tissue Sarcoma" Journal of Mind and Medical Sciences 11, no. 2: 388-395. https://doi.org/10.22543/2392-7674.1528

APA Style

Serban, B., Radu, E., Cursaru, A., Cretu, B. S., Iordache, S. A., Cirnu, M., Niculae, C. F., & Cîrstoiu, C. F. (2024). Survival Prognostic Factors and Molecular Aspects in Extremity Soft Tissue Sarcoma. Journal of Mind and Medical Sciences, 11(2), 388-395. https://doi.org/10.22543/2392-7674.1528

Article Metrics

Back to TopTop