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Volume 11
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10.22543/2392-7674.1537
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Article

Gastrointestinal Stromal Tumors: A Focus on the Impact of Interstitial Cells of Cajal in Disease Development

by
Petru Radu
1,
Mihai Zurzu
1,*,
Anca Tigora
1,
Vlad Paic
1,
Mircea Bratucu
1,
Dragos Garofil
1,
Valeriu Surlin
2,
Stefan Patrascu
2,
Virgiliu Prunoiu
1,
Ionut Simion Coman
1,
Valentin Georgescu
1,
Razvan Daniel Chivu
3,
Florian Popa
1,
Victor Strambu
1 and
Raluca Gabriela Ioan
4
1
Tenth Department of Surgery, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Sixth Department of Surgery, Craiova University of Medicine and Pharmacy, Craiova, Romania
3
Department of Social Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
4
Department of Gynecology, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2024, 11(2), 412-419; https://doi.org/10.22543/2392-7674.1537
Submission received: 12 May 2024 / Revised: 12 June 2024 / Accepted: 22 July 2024 / Published: 31 October 2024

Abstract

Introduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders. Recent research indicates a possible association between ICCs and the tumor risk of Gastrointestinal Stromal Tumors (GISTs). This research aims to examine the clinical, histopathological, and biomolecular characteristics of ICCs and their relevance in assessing GIST risk. Materials and Methods. This study examined fourteen GIST patients who underwent surgical intervention at the Surgery Department of Carol Davila Nephrology Hospital in Bucharest. Parameters including age, gender, tumor location/ dimensions were scrutinized. Immunohistochemistry employing markers CD117, DOG-1, and CD34 was employed to ascertain the presence of ICCs and GISTs. Results. The GIST risk stratification revealed distribution with 35.71% very low-risk, 21.42% low-risk, 14.28% intermediate-risk, and 28.57% high-risk categories. Predominantly, 57.14% of cases fell within the very low-risk and low-risk categories. Positive immunoreactivity for CD117 and DOG-1 was noted in 92.86% of patients, while CD34 exhibited positivity in 85.71% of cases. Gastric GISTs manifested heightened marker expression. Notably, immunohistochemistry unveiled robust positivity for CD117, DOG-1, and CD34, illustrating a positive correlation between elevated ICC levels and high-risk GISTs. Conclusions. The findings propose an association between ICC levels and high-risk GISTs, accentuating the diagnostic utility of CD117, DOG-1, and CD34 markers in GIST assessment.
Keywords: GIST; Cajal cells; CD117; CD34; DOG-1; ICC; immunohistochemistry GIST; Cajal cells; CD117; CD34; DOG-1; ICC; immunohistochemistry

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MDPI and ACS Style

Radu, P.; Zurzu, M.; Tigora, A.; Paic, V.; Bratucu, M.; Garofil, D.; Surlin, V.; Patrascu, S.; Prunoiu, V.; Coman, I.S.; et al. Gastrointestinal Stromal Tumors: A Focus on the Impact of Interstitial Cells of Cajal in Disease Development. J. Mind Med. Sci. 2024, 11, 412-419. https://doi.org/10.22543/2392-7674.1537

AMA Style

Radu P, Zurzu M, Tigora A, Paic V, Bratucu M, Garofil D, Surlin V, Patrascu S, Prunoiu V, Coman IS, et al. Gastrointestinal Stromal Tumors: A Focus on the Impact of Interstitial Cells of Cajal in Disease Development. Journal of Mind and Medical Sciences. 2024; 11(2):412-419. https://doi.org/10.22543/2392-7674.1537

Chicago/Turabian Style

Radu, Petru, Mihai Zurzu, Anca Tigora, Vlad Paic, Mircea Bratucu, Dragos Garofil, Valeriu Surlin, Stefan Patrascu, Virgiliu Prunoiu, Ionut Simion Coman, and et al. 2024. "Gastrointestinal Stromal Tumors: A Focus on the Impact of Interstitial Cells of Cajal in Disease Development" Journal of Mind and Medical Sciences 11, no. 2: 412-419. https://doi.org/10.22543/2392-7674.1537

APA Style

Radu, P., Zurzu, M., Tigora, A., Paic, V., Bratucu, M., Garofil, D., Surlin, V., Patrascu, S., Prunoiu, V., Coman, I. S., Georgescu, V., Chivu, R. D., Popa, F., Strambu, V., & Ioan, R. G. (2024). Gastrointestinal Stromal Tumors: A Focus on the Impact of Interstitial Cells of Cajal in Disease Development. Journal of Mind and Medical Sciences, 11(2), 412-419. https://doi.org/10.22543/2392-7674.1537

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