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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Case Report

Clinical-Evolutional Particularities of the Cryoglobulinemic Vasculitis in the Case of a Patient Diagnosed with Hepatitis C Virus in the Predialitic Phase

by
Daniel C. Caragea
1,2,
Larisa Săndulescu
3,
Vlad Pădureanu
4,
Mircea C. Forțofoiu
4,
Costin Streba
3,
Lidia Boldeanu
5,6,
Mihail V. Boldeanu
6,*,
Mircea Popescu-Drigă
6,
Marius E. Ciurea
7,
Maria Forțofoiu
8,
Ion Rogoveanu
3,
Tudorel Ciurea
3 and
Cristin C. Vere
3
1
Emergency County Hospital of Slatina, Slatina, Romania
2
Lisimed Medical Center, Slatina, Romania
3
Department of Gastroenterology, Craiova University of Medicine and Pharmacy, Craiova, Romania
4
Department of Internal Medicine, Craiova University of Medicine and Pharmacy, Craiova, Romania
5
Department of Microbiology, Craiova University of Medicine and Pharmacy, Craiova, Romania
6
Department of Immunology, Craiova University of Medicine and Pharmacy, Craiova, Romania
7
Department of Plastic Surgery, Craiova University of Medicine and Pharmacy, Craiova, Romania
8
Department of Emergency Medicine, Craiova University of Medicine and Pharmacy, Craiova, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2018, 5(1), 135-140; https://doi.org/10.22543/7674.51.P135140
Submission received: 25 January 2018 / Revised: 25 February 2018 / Accepted: 25 March 2018 / Published: 31 March 2018

Highlights

  • This case reveals the close connection between the infection with the HCV and the cryoglobulinemic vasculitis
  • The particularity is represented by both the existence from the outset of the vasculitic disease and the current predialitic stage of the patient

Abstract

Hepatitis C virus (HCV) represents a fundamental issue for public health, with long term evolution and the gradual appearance of several complications and associated pathologies. One of these pathologies is represented by cryoglobulinemic vasculitis, a disorder characterized by the appearance in the patient’s serum of the cryoglobulins, which typically precipitate at temperatures below normal body temperature (37 °C) and dissolve again if the serum is heated. Here, we describe the case of a patient diagnosed with HCV that, during the evolution of the hepatic disease, developed a form of cryoglobulinemic vasculitis. The connection between the vasculitis and the hepatic disorder was revealed following treatment with interferon, with the temporary remission of both pathologies and subsequent relapse at the end of the 12 months of treatment, the patient becoming a non-responder. The particularity of the case is represented by both the severity of the vasculitic disease from its onset and the deterioration of renal function up to the predialitic phase, a situation not typical of the evolution of cryoglobulinemia. Taking into account the hepatic disorder, the inevitable evolution towards cirrhosis, and the risk of developing the hepatocellular carcinoma, close monitoring is necessary.
Keywords: hepatitis C virus; cryoglobulinemic vasculitis; predialitic phase hepatitis C virus; cryoglobulinemic vasculitis; predialitic phase

Share and Cite

MDPI and ACS Style

Caragea, D.C.; Săndulescu, L.; Pădureanu, V.; Forțofoiu, M.C.; Streba, C.; Boldeanu, L.; Boldeanu, M.V.; Popescu-Drigă, M.; Ciurea, M.E.; Forțofoiu, M.; et al. Clinical-Evolutional Particularities of the Cryoglobulinemic Vasculitis in the Case of a Patient Diagnosed with Hepatitis C Virus in the Predialitic Phase. J. Mind Med. Sci. 2018, 5, 135-140. https://doi.org/10.22543/7674.51.P135140

AMA Style

Caragea DC, Săndulescu L, Pădureanu V, Forțofoiu MC, Streba C, Boldeanu L, Boldeanu MV, Popescu-Drigă M, Ciurea ME, Forțofoiu M, et al. Clinical-Evolutional Particularities of the Cryoglobulinemic Vasculitis in the Case of a Patient Diagnosed with Hepatitis C Virus in the Predialitic Phase. Journal of Mind and Medical Sciences. 2018; 5(1):135-140. https://doi.org/10.22543/7674.51.P135140

Chicago/Turabian Style

Caragea, Daniel C., Larisa Săndulescu, Vlad Pădureanu, Mircea C. Forțofoiu, Costin Streba, Lidia Boldeanu, Mihail V. Boldeanu, Mircea Popescu-Drigă, Marius E. Ciurea, Maria Forțofoiu, and et al. 2018. "Clinical-Evolutional Particularities of the Cryoglobulinemic Vasculitis in the Case of a Patient Diagnosed with Hepatitis C Virus in the Predialitic Phase" Journal of Mind and Medical Sciences 5, no. 1: 135-140. https://doi.org/10.22543/7674.51.P135140

APA Style

Caragea, D. C., Săndulescu, L., Pădureanu, V., Forțofoiu, M. C., Streba, C., Boldeanu, L., Boldeanu, M. V., Popescu-Drigă, M., Ciurea, M. E., Forțofoiu, M., Rogoveanu, I., Ciurea, T., & Vere, C. C. (2018). Clinical-Evolutional Particularities of the Cryoglobulinemic Vasculitis in the Case of a Patient Diagnosed with Hepatitis C Virus in the Predialitic Phase. Journal of Mind and Medical Sciences, 5(1), 135-140. https://doi.org/10.22543/7674.51.P135140

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