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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Article

Thrombocytopenia in End-Stage Renal Disease and Chronic Viral Hepatitis B or C

by
Olga Hilda Orasan
1,*,†,
Laura Urian
2,†,
George Ciulei
1,†,
Iulia Breaban
3,
Andreea Maria Stefan
3,
Sorina Cezara Secara
3,
Adela-Sitar Taut
1,
Simina Tarmure Sarlea
1,
Vasile Negrean
1,
Dorel Sampelean
1,
Ioan Mihai Patiu
4,
Remus Aurel Orasan
4 and
Angela Cozma
1
1
4th Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 400015 Cluj-Napoca, Romania
2
Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania
3
Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
4
Nefromed Dialysis Centers, Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this paper.
J. Mind Med. Sci. 2018, 5(2), 236-243; https://doi.org/10.22543/7674.52.P236243
Submission received: 31 July 2018 / Revised: 31 August 2018 / Accepted: 30 September 2018 / Published: 3 October 2018

Highlights

  • Thrombocytopenia is a common occurrence in patients with end-stage renal disease undergoing hemodialysis;
  • Chronic viral hepatitis B or C in end-stage renal disease patients does not impact platelet counts, suggesting that the natural course of liver disease is slowed in subjects undergoing hemodialysis

Abstract

Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis. Results. The presence of viral hepatitis was associated with a higher prevalence of thrombocytopenia. Correlations between age, C-reactive protein, liver stiffness measurement, and platelet count were observed. C-reactive protein levels > 10 mg/dL were associated with a lower risk of thrombocytopenia in patients with end-stage renal disease and chronic viral hepatitis, yet age > 60 years, dialysis vintage > 10 years, aspartate and alanine aminotransferase levels > 20 IU/L, albumin levels < 3.5 g/dL, and fibrosis stage ≥ 3 were not related. Conclusions. Chronic viral hepatitis leads to a higher prevalence of thrombocytopenia. Platelet counts in these patients begin to decrease significantly once liver fibrosis reaches stage III.
Keywords: thrombocytopenia; end-stage renal disease; chronic viral hepatitis thrombocytopenia; end-stage renal disease; chronic viral hepatitis

Share and Cite

MDPI and ACS Style

Orasan, O.H.; Urian, L.; Ciulei, G.; Breaban, I.; Stefan, A.M.; Secara, S.C.; Taut, A.-S.; Sarlea, S.T.; Negrean, V.; Sampelean, D.; et al. Thrombocytopenia in End-Stage Renal Disease and Chronic Viral Hepatitis B or C. J. Mind Med. Sci. 2018, 5, 236-243. https://doi.org/10.22543/7674.52.P236243

AMA Style

Orasan OH, Urian L, Ciulei G, Breaban I, Stefan AM, Secara SC, Taut A-S, Sarlea ST, Negrean V, Sampelean D, et al. Thrombocytopenia in End-Stage Renal Disease and Chronic Viral Hepatitis B or C. Journal of Mind and Medical Sciences. 2018; 5(2):236-243. https://doi.org/10.22543/7674.52.P236243

Chicago/Turabian Style

Orasan, Olga Hilda, Laura Urian, George Ciulei, Iulia Breaban, Andreea Maria Stefan, Sorina Cezara Secara, Adela-Sitar Taut, Simina Tarmure Sarlea, Vasile Negrean, Dorel Sampelean, and et al. 2018. "Thrombocytopenia in End-Stage Renal Disease and Chronic Viral Hepatitis B or C" Journal of Mind and Medical Sciences 5, no. 2: 236-243. https://doi.org/10.22543/7674.52.P236243

APA Style

Orasan, O. H., Urian, L., Ciulei, G., Breaban, I., Stefan, A. M., Secara, S. C., Taut, A.-S., Sarlea, S. T., Negrean, V., Sampelean, D., Patiu, I. M., Orasan, R. A., & Cozma, A. (2018). Thrombocytopenia in End-Stage Renal Disease and Chronic Viral Hepatitis B or C. Journal of Mind and Medical Sciences, 5(2), 236-243. https://doi.org/10.22543/7674.52.P236243

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