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10.22543/7674.72.P239244
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Case Report

Carbamazepine-Induced Dress Syndrome: A Case Report

by
Andrada Luciana Lazar
1,*,
Olga Hilda Orășan
2,
Corina Baican
1,
Nicolae Voicu Rednic
3,
Adela Sitar-Tăut
2,
Bogdan Man
4,
Vasile Negrean
2,
Nicolae Rednic
2 and
Angela Cozma
2
1
Department of Dermatology, ‘Iuliu HaţIeganu’ University of Medicine and Pharmacy, Clinicilor Street 3-5, Cluj-Napoca, Romania
2
Department of Internal Medicine, ‘Iuliu HaţIeganu’ University of Medicine and Pharmacy, Cluj-Napoca, Romania
3
Department of Gastroenterology, ‘Iuliu HaţIeganu’ University of Medicine and Pharmacy, Cluj-Napoca, Romania
4
Department of Internal Medicine, Emergency Hospital Bistrita, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2020, 7(2), 239-244; https://doi.org/10.22543/7674.72.P239244
Submission received: 11 May 2020 / Revised: 16 July 2020 / Accepted: 16 July 2020 / Published: 29 September 2020

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, idiosyncratic, acute adverse drug reaction. Fever, morbilliform cutaneous eruption, and eosinophilia are essential features for the diagnosis of this syndrome, along with significant multisystem involvement, hepatitis being the most common, followed by nephritis. The pathogenesis of DRESS syndrome is not yet fully understood. Several hypotheses have been proposed which support the involvement of an intricate interplay of multiple factors. We report a clinical case of DRESS syndrome with renal injury, induced by carbamazepine, in a patient with alcohol abstinence syndrome. In order to define the case, the RegiSCAR score and the Japanese Group score, used in the diagnosis of drug-induced hypersensitivity, were applied. DRESS syndrome is a potentially fatal disease, with a mortality that can reach up to 40% of cases. This condition endangers the patient's life by affecting the internal organs, mainly the liver, kidneys, heart, and lungs. Our case attempts to increase awareness among physicians about this serious disease and the importance of early diagnosis, especially since carbamazepine is a commonly used anticonvulsant drug.
Keywords: carbamazepine; drug hypersensitivity; eosinophilia; exanthema; lymphadenopathy carbamazepine; drug hypersensitivity; eosinophilia; exanthema; lymphadenopathy

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MDPI and ACS Style

Lazar, A.L.; Orășan, O.H.; Baican, C.; Rednic, N.V.; Sitar-Tăut, A.; Man, B.; Negrean, V.; Rednic, N.; Cozma, A. Carbamazepine-Induced Dress Syndrome: A Case Report. J. Mind Med. Sci. 2020, 7, 239-244. https://doi.org/10.22543/7674.72.P239244

AMA Style

Lazar AL, Orășan OH, Baican C, Rednic NV, Sitar-Tăut A, Man B, Negrean V, Rednic N, Cozma A. Carbamazepine-Induced Dress Syndrome: A Case Report. Journal of Mind and Medical Sciences. 2020; 7(2):239-244. https://doi.org/10.22543/7674.72.P239244

Chicago/Turabian Style

Lazar, Andrada Luciana, Olga Hilda Orășan, Corina Baican, Nicolae Voicu Rednic, Adela Sitar-Tăut, Bogdan Man, Vasile Negrean, Nicolae Rednic, and Angela Cozma. 2020. "Carbamazepine-Induced Dress Syndrome: A Case Report" Journal of Mind and Medical Sciences 7, no. 2: 239-244. https://doi.org/10.22543/7674.72.P239244

APA Style

Lazar, A. L., Orășan, O. H., Baican, C., Rednic, N. V., Sitar-Tăut, A., Man, B., Negrean, V., Rednic, N., & Cozma, A. (2020). Carbamazepine-Induced Dress Syndrome: A Case Report. Journal of Mind and Medical Sciences, 7(2), 239-244. https://doi.org/10.22543/7674.72.P239244

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