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Volume 7
Issue 2
10.22543/7674.72.P250256
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Case Report

Immunohistochemical Pattern—A Prognostic Factor for Synchronous Gastrointestinal Cancer

by
Catalin Alius
1,
Catalin Gabriel Cirstoveanu
2,3,
Cristinel Dumitru Badiu
2,4,*,
Valeriu Ardeleanu
5,6,7 and
Vasile Adrian Dumitru
8
1
IVth Department of Surgery, University Emergency Hospital Bucharest, Bucharest, Romania
2
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
3
Anesthesia and Intensive Neonatal Care Unit, Marie Curie Emergency Clinical Hospital, Bucharest, Romania
4
Bagdasar Arseni Emergency Clinical Hospital, 031298 Bucharest, Romania
5
Faculty of Medicine, Ovidius University, Constanta, Romania
6
Dunarea de Jos University, 47 Domneasca Street, Galati, Romania
7
General Hospital CFR, 4-6 Moruzzi Street, Galati, Romania
8
Department of Pathologic Anatomy, University Emergency Hospital Bucharest, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2020, 7(2), 250-256; https://doi.org/10.22543/7674.72.P250256
Submission received: 1 June 2020 / Revised: 25 August 2020 / Accepted: 4 September 2020 / Published: 29 September 2020

Abstract

Recent advancements in medical genetics and molecular biology are reflected in the modern understanding and approach to colorectal carcinoma (CRC). Understanding the cellular mechanisms and mutational patterns that promote carcinogenesis could enhance the predictive accuracy of the TNM classification. Furthermore, this will allow for a much more documented stratification and tailored oncological treatment. This paper presents an illustrative case of a relatively young patient (50 years old) with no family history of cancer who was diagnosed with four synchronous gastrointestinal (GI) adenocarcinomas displaying a wild type P53, negative BRAF testing, and mutated MLH1 and PMS2 proteins. This case report contributes to the relevant literature with a concise review of the role of micro-satellite instability (MSI), chromosomal instability (CIN), and CpG island methylator phenotype (CIMP) in carcinogenesis, hereditary and sporadic gastrointestinal cancers, a discussion over the importance of molecular sub-typing in predicting long term outcomes and choosing the most suitable adjuvant treatment regimen.
Keywords: microsatellite instability; synchronous gastrointestinal cancers; immunohistochemistry; mutational pattern microsatellite instability; synchronous gastrointestinal cancers; immunohistochemistry; mutational pattern

Share and Cite

MDPI and ACS Style

Alius, C.; Cirstoveanu, C.G.; Badiu, C.D.; Ardeleanu, V.; Dumitru, V.A. Immunohistochemical Pattern—A Prognostic Factor for Synchronous Gastrointestinal Cancer. J. Mind Med. Sci. 2020, 7, 250-256. https://doi.org/10.22543/7674.72.P250256

AMA Style

Alius C, Cirstoveanu CG, Badiu CD, Ardeleanu V, Dumitru VA. Immunohistochemical Pattern—A Prognostic Factor for Synchronous Gastrointestinal Cancer. Journal of Mind and Medical Sciences. 2020; 7(2):250-256. https://doi.org/10.22543/7674.72.P250256

Chicago/Turabian Style

Alius, Catalin, Catalin Gabriel Cirstoveanu, Cristinel Dumitru Badiu, Valeriu Ardeleanu, and Vasile Adrian Dumitru. 2020. "Immunohistochemical Pattern—A Prognostic Factor for Synchronous Gastrointestinal Cancer" Journal of Mind and Medical Sciences 7, no. 2: 250-256. https://doi.org/10.22543/7674.72.P250256

APA Style

Alius, C., Cirstoveanu, C. G., Badiu, C. D., Ardeleanu, V., & Dumitru, V. A. (2020). Immunohistochemical Pattern—A Prognostic Factor for Synchronous Gastrointestinal Cancer. Journal of Mind and Medical Sciences, 7(2), 250-256. https://doi.org/10.22543/7674.72.P250256

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