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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

Biostimulation with Low-Level Laser Therapy and Its Effects on Soft and Hard Tissue Regeneration. Literature Review

by
Anida Maria Babtan
1,
Aranka Ilea
1,
Claudia Nicoleta Feurdean
1,*,
Sabino Ceci
3,#,
Berate Pula
2,#,
Sebastian Candrea
1,
Daniela Azzollini
3,
Fabio Piras
3,
Luigi Curatoli
4,
Alberto Corriero
5,
Assunta Patano
3,
Francesco Valente
3,
Maria Elena Maggiore
3,
Antonio Mancini
3,
Delia Giovanniello
6,
Ludovica Nucci
7,
Rossella Elia
8,
Adina Sirbu
3,##,
Nausica Bianca Petrescu
9,
Codruta Mirica
9,
Andrea Galderisi
10 and
Filippo Cardarelli
3,##add Show full author list remove Hide full author list
1
Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, No. 5 Babes Street, 400012 Cluj-Napoca, Romania
2
Allias Vure Privat Clinic, Rruga 5 Maji, 1017 Tirane, Albania
3
Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, Bari, Italy
4
Department Neurosciences & Sensory Organs & Musculoskeletal System, University of Bari Aldo Moro, Bari, Italy
5
Unit of Anesthesia and Resuscitation, Department of Emergencies and Organ Transplantations, University of Bari Aldo Moro, Bari, Italy
6
Hospital a.o.s.g. Moscati, Contrada Amoretta, Cap, 83100 Avellino, Italy
7
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, Naples, Italy
8
Place Giulio Cesare, University of Bari Aldo Moro, 11 Bari Cap, 70124 Bari, Italy
9
Department of Oral Health, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
10
Universita Degli Studi Di Napoli Federico Ii, Napoli, Italy
*
Author to whom correspondence should be addressed.
#
Contributed equally to this work as co-first authors.
##
Contributed equally to this work as co-last authors.
J. Mind Med. Sci. 2022, 9(1), 28-37; https://doi.org/10.22543/7674.91.P2837
Submission received: 26 August 2021 / Revised: 27 August 2021 / Accepted: 31 December 2021 / Published: 10 April 2022

Abstract

Objective. Low-Level Laser Therapy encourages the healing process, reduces inflammation and pain. The aim of this study is to identify the impact of Low-Level Laser Therapy on tissue regeneration with special attention to hard tissues and to compare the effect of several wave lengths in the proliferation and differentiation of cells. Methods. The keywords used were “bone regeneration”, “laser therapy”, “photobiomodulation” OR “bio-stimulation”, “Low-Level Laser therapy” OR “LLLT”, “osteoblast proliferation” AND “differentiation”. Results. The bio-stimulation with Low-Level Laser Therapy also seems to interfere with the osseous integration of implants, by increasing its adherence on the bone-implant surfaces. Evidence has shown that Low-Level Laser Therapy influences the cellular proliferation and differentiation. Conclusions. Low-Level Laser Therapy is a promising therapy in the field of regeneration, but further studies are needed in order to define the standard protocol.
Keywords: photobiostimulation; low-level laser therapy; biomodulation; bone regeneration; cell proliferation; cell differentiation photobiostimulation; low-level laser therapy; biomodulation; bone regeneration; cell proliferation; cell differentiation

Share and Cite

MDPI and ACS Style

Babtan, A.M.; Ilea, A.; Feurdean, C.N.; Ceci, S.; Pula, B.; Candrea, S.; Azzollini, D.; Piras, F.; Curatoli, L.; Corriero, A.; et al. Biostimulation with Low-Level Laser Therapy and Its Effects on Soft and Hard Tissue Regeneration. Literature Review. J. Mind Med. Sci. 2022, 9, 28-37. https://doi.org/10.22543/7674.91.P2837

AMA Style

Babtan AM, Ilea A, Feurdean CN, Ceci S, Pula B, Candrea S, Azzollini D, Piras F, Curatoli L, Corriero A, et al. Biostimulation with Low-Level Laser Therapy and Its Effects on Soft and Hard Tissue Regeneration. Literature Review. Journal of Mind and Medical Sciences. 2022; 9(1):28-37. https://doi.org/10.22543/7674.91.P2837

Chicago/Turabian Style

Babtan, Anida Maria, Aranka Ilea, Claudia Nicoleta Feurdean, Sabino Ceci, Berate Pula, Sebastian Candrea, Daniela Azzollini, Fabio Piras, Luigi Curatoli, Alberto Corriero, and et al. 2022. "Biostimulation with Low-Level Laser Therapy and Its Effects on Soft and Hard Tissue Regeneration. Literature Review" Journal of Mind and Medical Sciences 9, no. 1: 28-37. https://doi.org/10.22543/7674.91.P2837

APA Style

Babtan, A. M., Ilea, A., Feurdean, C. N., Ceci, S., Pula, B., Candrea, S., Azzollini, D., Piras, F., Curatoli, L., Corriero, A., Patano, A., Valente, F., Maggiore, M. E., Mancini, A., Giovanniello, D., Nucci, L., Elia, R., Sirbu, A., Petrescu, N. B., ... Cardarelli, F. (2022). Biostimulation with Low-Level Laser Therapy and Its Effects on Soft and Hard Tissue Regeneration. Literature Review. Journal of Mind and Medical Sciences, 9(1), 28-37. https://doi.org/10.22543/7674.91.P2837

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