Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review
Abstract
:1. Introduction
2. Robotic Technologies in Pharmaceutical Manufacturing
- Automation of manufacturing processes: Robots and automated systems are increasingly being used to perform a variety of tasks, including compounding, dosing, forming, and filling of medicinal products.
- Automated mixing and dosing systems allow for accurate dosing and mixing of drug components, which ensures product uniformity and reduces the risk of deviations from quality standards.
- Packaging and labeling: Robots can automatically package, label, and stack finished products, helping to increase efficiency and reduce labor costs.
- Warehousing operations: Robots can be used to automate the warehousing, shipping, and transportation processes of products, ensuring a high level of compliance and quality assurance.
- High-speed sorting and analysis: Robots can perform high-speed procedures such as component sorting or drug testing, increasing productivity and ensuring the accuracy of results.
- Collaborative robots (cobots) in drug manufacturing: Cobots work alongside human operators to perform tasks such as drug packaging and labeling, enhancing productivity while reducing the potential for errors.
- Robotic quality control systems: Advanced robotics and machine vision technologies are employed to inspect pharmaceutical products for defects, ensuring compliance with stringent quality standards and reducing the likelihood of product recalls. They can also monitor compliance of manufacturing processes with GMP (good manufacturing practice) standards.
- 3D printing of drugs: The use of 3D printing in the field of drug production allows for the creation of personalized doses and forms of drugs that can take into account the individual needs of patients. Furthermore, 3D printing can help in the manufacture of complex tablet geometries, improving their solubility and bioavailability.
- Personalized medicine [44]: One of the most promising applications of 3D printing in drug production is the creation of personalized medications. With 3D printing, it is possible to tailor drugs to specific patients by adjusting the dosage, release profile, and even the combination of active pharmaceutical ingredients (APIs) based on individual needs. This can lead to more effective treatments and reduced side effects for patients.
- Complex drug formulations [45]: Three-dimensional printing enables the production of complex drug formulations that may be challenging for manufacture using traditional methods. For example, it can create multilayered tablets with different release profiles for each layer or intricate geometries that can affect the drug’s dissolution and absorption rates.
- Rapid prototyping and development [46]: Three-dimensional printing can significantly speed up the drug development process by allowing researchers to create and test new drug formulations and delivery systems. This can reduce the time and cost associated with bringing new medications to market.
- On-demand production [47,48]: Three-dimensional printing enables decentralized and on-demand drug production, allowing for smaller batch sizes and reduced inventory costs. This can be particularly beneficial where immediate access to medication is needed, such as in disaster relief or remote locations.
3. Robotic Drug Delivery Systems
4. Robotic Technologies in Medicine
5. Artificial Intelligence and Robotics in Drug Discovery and Health Care
- Target identification: AI algorithms can analyze large datasets, such as genomic, proteomic, and metabolomic data, to identify potential drug targets and elucidate disease mechanisms [176]. This process enables researchers to better understand the molecular basis of diseases and pinpoint suitable targets for drug development.
- Compound screening: AI-driven virtual screening methods can identify promising drug candidates from vast libraries of compounds more efficiently than traditional high-throughput screening methods. AI algorithms can predict the biological activity, toxicity, and pharmacokinetic properties of potential drug candidates, thereby reducing the time and resources required for experimental validation [177].
- De novo drug design: AI can help design new drug molecules from scratch by leveraging deep learning techniques to predict the properties of potential compounds [178]. Generative adversarial networks (GANs) and other machine learning algorithms can create novel molecular structures with the desired biological activity and drug-like properties [179].
- Drug repurposing: AI can analyze existing drugs and their effects to identify new therapeutic uses, significantly reducing the time and cost of drug development. By analyzing the molecular profiles of approved drugs, AI can predict their potential efficacy in treating other diseases or conditions [180].
- Biomarker discovery: AI can analyze vast amounts of biological data to identify biomarkers that can be used for early disease detection, diagnosis, prognosis, or monitoring treatment response. These biomarkers can help tailor therapies to individual patients, leading to more effective treatments and better patient outcomes [181].
- Optimization of lead compounds: AI algorithms can optimize lead compounds by predicting the impact of chemical modifications on their pharmacological properties, such as potency, selectivity, and safety. This approach enables researchers to iteratively improve drug candidates before advancing to preclinical and clinical testing [182].
6. Ethical Considerations and Challenges in Implementing AI and Robotic Technologies in Health Care
7. Future Promising Technologies and Research Opportunities for Robotics Technologies and AI in Pharmacy and Medicine
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Supplier Name, Country | Robotic Solutions for the Pharmaceutical Industry | Examples of Robotic Solutions |
---|---|---|
ABB Robotics, Switzerland | Robots are designed for tasks such as drug manufacturing, packaging, and quality control. | ABB’s FlexPicker robots [16,17,18] provide high-speed and precision handling for various pharmaceutical products. Its advanced vision system and software enable it to adapt quickly to different product shapes and sizes, making it suitable for a wide range of pharmaceutical manufacturing applications. |
KUKA Robotics, Germany | Robots are utilized in various applications, such as drug manufacturing, assembly, and packaging. | The KR AGILUS robot (KUKA Robotics) series [19] is known for its speed, precision, and adaptability in handling delicate pharmaceutical products. Its advanced software and control systems allow for seamless integration with existing production lines and offer flexibility in programming for various tasks, such as drug manufacturing, assembly, and packaging. |
FANUC Corporation, Japan | Robots are used for tasks such as drug dispensing, packaging, and assembly. | FANUC’s M-1iA robot series [20] is a family of high-speed, lightweight robots designed for the precision assembly and handling of small pharmaceutical components. These robots are equipped with FANUC’s proprietary software and control systems, which enable them to perform complex tasks with high accuracy and efficiency. |
Universal Robots, Denmark | Specializes in collaborative robots (cobots), which can be easily programmed and adapted for drug packaging, labeling, and quality control. | The UR series of cobots [21] are known for their ease of use, flexibility, and safety features. These cobots are equipped with intuitive software that allows for easy programming and adaptation for tasks such as drug packaging, labeling, and quality control. |
Stryker Corporation, USA | Robotic systems are used for tasks like precision drug dispensing and product assembly, helping to ensure accuracy and reduce human error. | The Mako Robotic-Arm Assisted Surgery System [22,23] is a robotic assisted surgery platform designed for precision drug dispensing and product assembly. This system is powered by advanced software that helps ensure accuracy and reduce human error during the manufacturing process. |
Syntegon, Germany | Machines are used for tasks like filling, packaging, and labeling of pharmaceutical products. | The RAN series of robotic systems [24,25] are designed for high-speed, precise handling and packaging of various drug formats. These systems are equipped with advanced software and control systems that enable them to adapt to different product types and production requirements. |
Yaskawa Motoman, Japan | Robotic systems are employed in the pharmaceutical industry for applications such as drug manufacturing, quality control, and packaging. | The Motoman GP series of robots are known for their precision and reliability in handling delicate pharmaceutical products [26]. |
Omron Corporation, Japan | Robots are used in applications like drug manufacturing, assembly, and inspection. | Omron’s LD Mobile Robot series [27] is designed for material transportation and handling in pharmaceutical manufacturing facilities. |
Stäubli Robotics, Switzerland | Robots are utilized for tasks such as drug manufacturing, packaging, and quality control. | Stäubli’s TX2 series of robots [28] are known for their cleanroom compatibility, making them suitable for use in sterile pharmaceutical production environments. Their advanced software and control systems ensure precise and efficient operation in various tasks, such as drug manufacturing, packaging, and quality control. |
Denso Robotics, Japan | Robots are employed in the pharmaceutical industry for applications like drug manufacturing, packaging, and inspection. | Denso’s VS series of robots [29] are designed for high-speed and precision handling of pharmaceutical products, helping to improve productivity and quality. |
Honeywell, USA | Offers automated solutions for the pharmaceutical industry, including production management, process monitoring, and quality control systems. | Automated storage and retrieval system (AS/RS), autonomous mobile robots (AMRs), and Pallet Accuglide™ conveyor [30]. |
IMA Group, Italy | Automated solutions for packaging, dosing, labeling, and other manufacturing processes. | IMA Swiftpack SWIFTLIFT Tablet Elevator and continuous direct compression line [31]. |
Robotic Technologies and Automated Systems | Application |
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Automated Vision Inspection Systems | Such systems use advanced cameras, sensors, and image processing software to inspect pharmaceutical products, such as tablets [32], capsules [33], and vials [34], for defects or inconsistencies. By automating the inspection process, these systems can quickly and accurately identify issues, such as incorrect labeling, damaged packaging, or improper tablet shapes and sizes, ensuring only high-quality products reach consumers [35]. |
Collaborative Robots (Cobots) | Cobots [36,37], such as Universal Robots’ UR series, are designed to work alongside human operators in quality control processes. They can be easily programmed and adapted for tasks, such as drug packaging inspection, label verification, and quality control checks. Their advanced safety features ensure minimal risk to human operators while improving the overall efficiency of the quality control process. |
High-Speed Sorting and Inspection Robots | Robots like ABB’s FlexPicker and KUKA’s KR AGILUS series are used for high-speed sorting and inspection of pharmaceutical products [37,38]. They can quickly and accurately sort products based on various criteria, such as size, shape, color, or weight, and identify any defects or inconsistencies in the process. |
Sample Testing and Analysis Robots | These robotic systems [39] automate the process of collecting and analyzing samples from drug production batches. By using advanced sensors and analytical tools, they can quickly and accurately test samples for quality parameters, such as purity, potency, and stability, ensuring that products meet strict regulatory standards. |
Robotic Liquid Handling Systems | These systems [40] are involved in the processes of transferring, measuring, and mixing liquids in the pharmaceutical manufacturing and quality control process. With high precision and accuracy, these robots ensure consistency in drug formulation and reduce the risk of human error, helping to maintain strict quality standards. |
Robotic X-ray Inspection Systems | These systems [39] use advanced X-ray technology to inspect pharmaceutical products and packaging for defects, such as foreign particles, contaminants, or improper sealing. By automating this process, these robots can quickly and accurately identify issues, ensuring that only high-quality products reach the market. |
Company/Research Institution, Country | Application of 3D Printing | 3D-Printed Pharmaceutical Product/Patented Technology |
---|---|---|
Aprecia Pharmaceuticals, USA | Aprecia is a pioneer in 3D printing for pharmaceuticals and developed the first FDA-approved 3D-printed drug, Spritam. The company’s proprietary ZipDose technology enables the creation of rapidly dissolving oral medications, which can improve patient adherence and make it easier for patients to take their medication. |
|
FabRx, UK | FabRx focuses on developing 3D printing technologies for personalized medicine. The company researches various 3D printing methods, such as selective laser sintering (SLS) [56], fused deposition modeling (FDM) [57], and stereolithography (SLA) [58], to produce customized drug dosages and release profiles based on individual patients. |
|
Nano3D Biosciences, USA | Nano3D Biosciences focuses on developing bioprinting technologies for drug discovery and development [61]. | Magnetic 3D bioprinting technology [62,63] can be used to create complex tissue structures for drug testing, which can help improve the efficiency and accuracy of drug development processes. |
ExOne, USA | ExOne explores the use of its technology to create custom drug dosages and formulations, as well as drug delivery devices [64,65,66]. | Freeman technology [65]. |
T3D Therapeutics, USA | T3D Therapeutics focuses on using 3D printing technology to create customized medications for the treatment of neurological disorders, such as Alzheimer’s disease. | Their 3D printing technology enables the precise control of drug release profiles, potentially improving treatment outcomes and reducing side effects for patients [67]. |
Paragon Medical, USA | Paragon Medical focused on the development of 3D printing technologies for various industries, including pharmaceuticals [68]. | The company researches and develops new techniques for creating complex drug formulations, drug delivery devices, and personalized medications using 3D printing [69]. |
Exaddon, North Carolina State University and the University of North Carolina, USA | Exaddon develops microneedles made from cooper that can be designed with varying shapes and sizes to control the release of drugs through the skin for delivery. | Exaddon technology for the printing of microneedles [70,71]. |
Drug Delivery System | Application | Example of Drug Delivery Systems |
---|---|---|
Robot-assisted intravenous (IV) therapy | These systems for intravenous medications [76] help minimize human errors, improve safety, and reduce the risk of contamination during the preparation process. | RIVA (Robotic IV Automation) system from ARxIUM or the IV Compounding Robot from Aesynt |
Capsule robots for gastrointestinal drug delivery | Capsule robots can provide external control to deliver drugs to specific locations within the gastrointestinal tract. These robots have the potential to improve drug absorption, reduce side effects, and enable targeted therapy for conditions such as inflammatory bowel disease or gastrointestinal tumors [74,77]. | RoboCap from Massachusetts Institute of Technology |
Robotic needle guidance systems | Such systems can accurately position needles for drug injections or biopsies. These systems use advanced imaging and AI algorithms to improve accuracy, reduce complications, and shorten procedure times [78,79,80]. | Robotic needle guidance systems from XACT Robotics |
Implantable drug delivery devices | Such devices can be remotely controlled to release drugs on demand or according to a predetermined schedule. Such devices have the potential to improve patient adherence, reduce the frequency of drug administration, and enable more precise dosing [81]. | LACRISERT from Bausch + Lomb |
Wearable drug delivery systems | Systems can automatically administer drugs according to programmed schedules or in response to real-time physiological data. These devices can improve treatment outcomes by ensuring consistent drug delivery and reducing the burden on patients [82,83]. | Chrono Therapeutics’ SmartStop and the insulin delivery systems developed by Insulet and Tandem Diabetes Care |
Robotic pharmacy dispensing systems | Automated pharmacy dispensing systems [84,85,86] help to improve the accuracy and efficiency of medication dispensing, reducing the risk of medication errors and freeing up pharmacy staff to focus on patient care. | The PillPick system from Swisslog Healthcare or the ARxIUM FastPak Elite |
Soft robotic drug delivery systems | These systems can change shape and size to navigate through the body and deliver drugs to specific locations [87]. These flexible robots made from materials like hydrogels or elastomers can adapt to the body’s internal environment and minimize the risk of injury during drug delivery. | Millirobot from City University of Hong Kong and Shenzhen Institutes of Advanced Technology |
Nanorobotic drug delivery | These systems use nanoscale robots to transport and release drugs within the body. These tiny robots can be engineered to respond to specific environmental stimuli, such as pH or temperature, ensuring targeted and controlled drug delivery [88,89]. | Nanobots for cancer treatment from Elan Pharmaceuticals, Merck’s Emend, and Wyeth’s Rapamune |
Robotic exoskeletons for drug delivery | Robotic exoskeletons are being researched for drug delivery applications [90,91]. These wearable robotic devices could potentially administer medications directly into the bloodstream, bypassing the gastrointestinal system and improving bioavailability. | Robotic exoskeletons from ReWalk Robotics and Ekso Bionics |
Robotic catheter systems | Robotic catheter systems enable precise navigation of catheters within the body to deliver drugs directly to targeted tissues or organs [92,93,94]. This can enhance the effectiveness of treatments while reducing systemic side effects. | Robotic catheter systems from Auris Health and Corindus Vascular Robotics |
Robotic pill dispensers | Robotic pill dispensers use automation and artificial intelligence to dispense the right medications at the right time for patients [86,87]. These systems help improve patient adherence to treatment regimens and reduce the risk of medication errors [95,96]. | The Pillo Health or the Hero Medication Dispenser |
Direction of Robotic Technology Applications | Application |
---|---|
Personal health monitoring | Wearable robotic devices, such as smartwatches or fitness trackers, monitor an individual’s vital signs, sleep patterns, and activity levels. This information can be used to provide personalized health insights and recommendations [100]. |
Robotic surgery | Robotic surgical systems, such as the da Vinci Surgical System [101] by Intuitive Surgical, are used to perform minimally invasive procedures with greater precision and control. These systems provide enhanced visualization, improved dexterity, and increased accuracy, leading to shorter recovery times and reduced risk of complications for patients. |
Rehabilitation robotics | Robotic devices are being used to support physical therapy and rehabilitation. Examples include exoskeletons like the ReWalk system [102], which assists individuals with spinal cord injuries in walking, and robotic devices like the InMotion Arm by Bionik Laboratories [103]. The latter helps patients regain upper limb function and can be used at home to support physical therapy and rehabilitation for patients recovering from stroke or other neurological conditions. These devices provide personalized therapy, enabling patients to receive tailored treatment in the comfort of their own homes. |
Telemedicine robots | Telepresence robots [104,105,106], such as those developed by InTouch Health and Intuitive Surgical, enable healthcare professionals to remotely diagnose, consult, and treat patients. These robots use high-definition cameras and real-time communication systems to connect patients with healthcare providers, regardless of their physical location. |
Robotic prosthetics and orthotics | Advanced prosthetic limbs, such as the DEKA Arm (also known as the “Luke Arm”) [107] and the BiOM T2 Ankle [108], use robotic technology to mimic natural limb movements and provide users with increased functionality and mobility [109]. |
Robotic drug delivery systems | Innovative robotic drug delivery systems are being developed to improve the efficiency, safety, and patient experience in drug administration (see item 3). |
Robotic nursing assistants | Robotic nursing assistants, such as Moxi by Diligent Robotics [110] and Robear by RIKEN [111], are designed to perform routine tasks like delivering medication, collecting lab samples, and assisting with patient transport. These robots help free up medical staff to focus on more complex patient care tasks. |
Diagnostic robots | Robotic systems are being developed to aid in diagnostics. For example, the PillCam by Given Imaging [112] is a swallowable capsule camera that captures images of the gastrointestinal tract. Another example is the robotic catheter system by Auris Health [93], which aids in diagnosing and treating lung cancer. |
Laboratory automation | Robotic systems like the Hamilton STAR and Tecan Freedom EVO [113] are used to automate laboratory processes, increasing efficiency, reducing human error, and improving the quality of data collected in medical research. |
Personalized drug delivery | Robotic drug delivery systems like thosed discussed earlier can be tailored to individual patient needs, ensuring targeted and controlled drug delivery for optimal therapeutic outcomes. |
Direction of AI and Robotics Applications | Application | Companies Working on These Solutions |
---|---|---|
Drug discovery | Analysis of large datasets and identification of potential drug candidates or targets, significantly speeding up the drug discovery process. | Atomwise [123,124], BenevolentAI [125], Insilico Medicine [126] |
Diagnostics and imaging | Analysis of medical images, such as X-rays, MRIs, or CT scans and faster speed and accuracy of detection of abnormalities than human specialists. | Aidoc [127,128], Zebra Medical Vision [129], PathAI [130] |
Precision medicine | Analysis of genetic, clinical, and lifestyle data to help tailor medical treatments to individual patients, improving outcomes and reducing side effects. | Tempus [131], Deep Genomics [132,133], 23andMe [134] |
Virtual health assistants | AI-powered virtual health assistants [135], such as chatbots or voice assistants, to provide medical advice, answer health-related questions, and help schedule appointments. | Ada Health [136], Babylon Health [137], Buoy Health [138] |
Remote patient monitoring | Analysis of data collected from wearable devices, alerting healthcare providers of any abnormalities, allowing for early intervention and improved patient care. | Biofourmis [139], Current Health [140] |
Robotic surgery | Robotic surgical systems, such as the da Vinci Surgical System [101], enable surgeons to perform minimally invasive procedures with greater precision and control, leading to better patient outcomes. | Intuitive Surgical [101], Medtronic [141], Stryker [22,23] |
Early disease detection | Prediction of the likelihood of diseases based on patient data and identification of early warning signs, facilitating early intervention and treatment [142]. | Freenome [143], ClosedLoop.ai [144] |
Mental health and therapy | AI-driven chatbots and apps provide personalized support and therapy for individuals dealing with mental health issues, such as anxiety, depression, or post-traumatic stress disorder. | Woebot [145], Wysa [146], Talkspace [147] |
Radiology and pathology | AI-based algorithms can help radiologists and pathologists interpret medical images, improving diagnostic accuracy and efficiency [148]. | Butterfly Network [149], Enlitic [150], Paige.AI [151] |
Medical transcription and natural language processing | Transcription and analysis of spoken or written medical language, streamlining the documentation process and reducing the administrative burden on healthcare professionals [152]. | Nuance Communications [153], DeepScribe [154], Google Cloud Healthcare API [155] |
Clinical decision support | AI-powered decision support tools help healthcare professionals make better-informed decisions, reducing errors and improving patient care [156,157]. | IBM Watson Health [158], Cerner [159], ZS [160] |
Medical supply chain management | Optimization of the supply chain, helping to manage inventory and reduce waste [161]. | Gauss Surgical [162], Swisslog Healthcare [163], Omnicell [164] |
Infection control and prevention | Robots equipped with UV-C light technology can be used to sanitize medical facilities, reducing the risk of hospital-acquired infections. | Xenex [165,166], UVD Robots [167,168], Surfacide [169] |
Predictive analytics | AI-powered predictive analytics can be used to anticipate patient needs, optimize hospital resources, and identify high-risk patient populations [170]. | Medial EarlySign [171] |
Personalized patient engagement | Creation of personalized care plans and interventions based on patient data, improving patient adherence to treatment and overall health outcomes [172]. | Lark Health [173], Wellframe [174], GYANT [175] |
Company Name | Application of AI | Company Homepage |
---|---|---|
Atomwise | Structure-based drug design and compound screening to identify potential drug candidates | https://www.atomwise.com |
BenevolentAI | Identification of drug targets, design of molecules, and optimization of drug candidates | https://www.benevolent.com |
Insilico Medicine | Target identification, molecule generation, and drug repurposing | https://insilico.com |
Exscientia | Design and optimization of drug candidates in a range of therapeutic areas | https://www.exscientia.ai |
Recursion Pharmaceuticals | AI-based image analysis and machine learning to analyze cellular phenotypes for drug discovery and repurposing | https://www.recursion.com |
Deep Genomics | Prediction of the effects of genetic mutations and development of therapies for genetic diseases | https://www.deepgenomics.com/platform/ |
Schrödinger | Computational methods and AI for molecular modeling, design of novel compounds with desired properties, and optimization of existing drug candidates | https://www.schrodinger.com |
ARIA Pharmaceuticals | AI-driven drug discovery for various therapeutic areas, leveraging large-scale data integration and machine learning algorithms to identify promising drug candidates | https://ariapharmaceuticals.com |
Cyclica | In silico drug discovery using a combination of deep learning and molecular dynamics simulations to predict drug–target interactions, off-target effects, and ADMET properties | https://cyclicarx.com |
BioXcel Therapeutics | Identification and development of innovative therapies by repurposing existing drugs and designing new drug candidates | https://www.bioxceltherapeutics.com |
Numerate | Design, optimization, and validation of small molecule drug candidates, focusing on areas such as oncology, immunology, and metabolic diseases | http://www.numerate.com |
A2A Pharmaceuticals | Design and development of novel drug candidates for difficult-to-drug targets, aiming to treat cancer, infectious diseases, and other conditions | https://www.a2apharma.com |
Cloud Pharmaceuticals | Design and optimization of drug candidates, focusing on areas such as oncology, inflammation, and central nervous system disorders | https://www.cloudpharmaceuticals.com |
Lantern Pharma | Identification and development of precision oncology therapies by repurposing existing drugs and discovering new drug candidates | https://www.lanternpharma.com |
Owkin | Analysis of multimodal medical data, including imaging and omics data, to identify biomarkers and develop predictive models for drug discovery and personalized medicine | https://owkin.com |
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Stasevych, M.; Zvarych, V. Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review. Big Data Cogn. Comput. 2023, 7, 147. https://doi.org/10.3390/bdcc7030147
Stasevych M, Zvarych V. Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review. Big Data and Cognitive Computing. 2023; 7(3):147. https://doi.org/10.3390/bdcc7030147
Chicago/Turabian StyleStasevych, Maryna, and Viktor Zvarych. 2023. "Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review" Big Data and Cognitive Computing 7, no. 3: 147. https://doi.org/10.3390/bdcc7030147
APA StyleStasevych, M., & Zvarych, V. (2023). Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review. Big Data and Cognitive Computing, 7(3), 147. https://doi.org/10.3390/bdcc7030147