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Abstract

Effect of Saccharomyces cerevisiae Yeast-Based Supplement on Human Milk Oligosaccharide Concentration and Mothers’ Perception of Breast Milk Supply: A Randomized Placebo-Controlled Trial †

by
Lili Lily Jia
,
Louise Brough
and
Janet L. Weber
*
School of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
†
Presented at the More Than Just Milk Lactation Science Symposium, Perth, Australia, 25 November 2022.
Proceedings 2023, 84(1), 16; https://doi.org/10.3390/proceedings2023084016
Published: 13 March 2023
(This article belongs to the Proceedings of More Than Just Milk Lactation Science Symposium)
Versions Notes

Abstract

:
Saccharomyces cerevisiae yeast-based supplement (SCYS) is frequently used as a galactagogue. However, its efficacy has only been evaluated in lactating ruminants and sows, not humans. This study aims to investigate the effect of taking an SCYS on human milk oligosaccharide (HMO) concentration and perceived insufficient milk supply (PIM). A randomized, double-blind, placebo-controlled trial was conducted at Palmerston North, New Zealand from May 2019–July 2021. Breastfeeding women with a term infant aged 1–7 months were randomly assigned to consume an SCYS (5 g/day) or placebo for four weeks. Concentration of 11 HMOs were analyzed by UHPLC with fluorescence detection. Online questionnaires were used to evaluate PIM, postnatal distress, infant feeding status, and self-reported side effects of taking SCYS. In addition, the infants’ feeding pattern (duration and frequency of breastfeed) were examined using a 24-hour feeding record. Sixty-eight women completed this study. The SCYS had no effect on individual or total HMO concentration. There were no significant differences in PIM, postnatal distress, or infant feeding pattern between the SCYS and placebo groups. However, more participants in the SCYS group than the placebo group perceived that the intervention increased their milk supply (65% vs. 35%, p < 0.05). Women in both groups reported adverse effects, but no participant withdrew from this study. The SCYS has no effect on HMO concentration or PIM. Research is needed to investigate the effect of SCYS on breast milk volume and self-reported indicators of milk supply increase.

Author Contributions

Conceptualization, L.L.J., L.B. and J.L.W.; methodology, L.L.J., L.B. and J.L.W.; formal analysis, L.L.J., L.B. and J.L.W.; investigation, L.L.J.; writing—original draft preparation, L.L.J.; writing—review and editing, L.L.J., L.B. and J.L.W. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki, and approved by Massey University Human Ethics Committee: Southern A (SOA 18/80, approved on 26 February 2019).

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

Data sharing not applicable.

Conflicts of Interest

The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Jia, L.L.; Brough, L.; Weber, J.L. Effect of Saccharomyces cerevisiae Yeast-Based Supplement on Human Milk Oligosaccharide Concentration and Mothers’ Perception of Breast Milk Supply: A Randomized Placebo-Controlled Trial. Proceedings 2023, 84, 16. https://doi.org/10.3390/proceedings2023084016

AMA Style

Jia LL, Brough L, Weber JL. Effect of Saccharomyces cerevisiae Yeast-Based Supplement on Human Milk Oligosaccharide Concentration and Mothers’ Perception of Breast Milk Supply: A Randomized Placebo-Controlled Trial. Proceedings. 2023; 84(1):16. https://doi.org/10.3390/proceedings2023084016

Chicago/Turabian Style

Jia, Lili Lily, Louise Brough, and Janet L. Weber. 2023. "Effect of Saccharomyces cerevisiae Yeast-Based Supplement on Human Milk Oligosaccharide Concentration and Mothers’ Perception of Breast Milk Supply: A Randomized Placebo-Controlled Trial" Proceedings 84, no. 1: 16. https://doi.org/10.3390/proceedings2023084016

APA Style

Jia, L. L., Brough, L., & Weber, J. L. (2023). Effect of Saccharomyces cerevisiae Yeast-Based Supplement on Human Milk Oligosaccharide Concentration and Mothers’ Perception of Breast Milk Supply: A Randomized Placebo-Controlled Trial. Proceedings, 84(1), 16. https://doi.org/10.3390/proceedings2023084016

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