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Volume 80
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10.5603/ARM.27587
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Case Report

Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report

by
Beata Gryglicka
1,*,
Irena Węgrzyn-Szkutnik
1,
Janusz Milanowski
1,
Sławomir Mandziuk
1,
Ludmiła Grzybowska-Szatkowska
2,
Dariusz Surdyka
3,
Elżbieta Czekajska-Chehab
4 and
Małgorzata Zdunek
5
1
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-950 Lublin, Poland
2
Department of Oncology, Medical University of Lublin, 20-950 Lublin, Poland
3
Radiotherapy Departament with Teletherapy and Brachytherapy Unit of Lublin Oncology Center, Lublin, Poland
4
Department of Diagnostic Radiology and Nuclear Medicine, Medical University of Lublin, 20-950 Lublin, Poland
5
Department of Clinical Pathomorfology, Medical University of Lublin, 20-950 Lublin, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2012, 80(3), 269-274; https://doi.org/10.5603/ARM.27587
Submission received: 30 May 2011 / Revised: 7 May 2012 / Accepted: 7 May 2012 / Published: 7 May 2012

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant counterpart to benign neurogenes tumors such as schwannomas and neurofibromas and account for approximately 5–10% of all soft tissue sarcomas. This neoplasm is also referred to older designations as a malignant schwannoma, malignant neurilemmoma or neurogenic sarcoma. A patient was a woman of 59 years old with a diagnosed malignant neurilemmoma, treated since 1993. Operated several times and subjected to radiotherapy due to the local recurrence of the tumors located in the soft tissues of the back until 2002; Treated with chemotherapy (doxorubicin) and operated due to lung metastases. The therapy resulted in a total remission that lasted 12 months. In 2004 a new small tumor was diagnosed in the right lung, which had been followed up until 2006. The patient did not give permission to a second surgery, treated with ifosfamide. In 2006 she was operated for renal cell carcinoma of the left kidney. In 2009, due to a following progression of neurilemmoma and a worsening overall condition, she was subsequently treated with a combination of gemcitabine and docetaxel. The treatment resulted in a slight improvement, but was stopped due to complications (pancytopenia). In 2010 another progression of the disease occurred, which resulted in pleural metastases and osteolytic lesions in the vertebrae (Th6 and L2).
Keywords: MPNST; neurilemmoma malignum; schwannoma malignum MPNST; neurilemmoma malignum; schwannoma malignum

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MDPI and ACS Style

Gryglicka, B.; Węgrzyn-Szkutnik, I.; Milanowski, J.; Mandziuk, S.; Grzybowska-Szatkowska, L.; Surdyka, D.; Czekajska-Chehab, E.; Zdunek, M. Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report. Adv. Respir. Med. 2012, 80, 269-274. https://doi.org/10.5603/ARM.27587

AMA Style

Gryglicka B, Węgrzyn-Szkutnik I, Milanowski J, Mandziuk S, Grzybowska-Szatkowska L, Surdyka D, Czekajska-Chehab E, Zdunek M. Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report. Advances in Respiratory Medicine. 2012; 80(3):269-274. https://doi.org/10.5603/ARM.27587

Chicago/Turabian Style

Gryglicka, Beata, Irena Węgrzyn-Szkutnik, Janusz Milanowski, Sławomir Mandziuk, Ludmiła Grzybowska-Szatkowska, Dariusz Surdyka, Elżbieta Czekajska-Chehab, and Małgorzata Zdunek. 2012. "Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report" Advances in Respiratory Medicine 80, no. 3: 269-274. https://doi.org/10.5603/ARM.27587

APA Style

Gryglicka, B., Węgrzyn-Szkutnik, I., Milanowski, J., Mandziuk, S., Grzybowska-Szatkowska, L., Surdyka, D., Czekajska-Chehab, E., & Zdunek, M. (2012). Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report. Advances in Respiratory Medicine, 80(3), 269-274. https://doi.org/10.5603/ARM.27587

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