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Diabetology
Volume 2
Issue 1
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Diabetology, Volume 2, Issue 1 (March 2021) – 3 articles

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Type 2 Diabetes (T2D) is the foremost cause of general mortality in Mexico. Mexico City, one of the most populated cities in the developing world, faces complex challenges to provide adequate health care to its more than 20 million inhabitants. This high concentration of population has placed the city among the top five cities with the highest diabetes mortality rates in the country.

Early detection and treatment of T2D is an important step toward keeping people with diabetes healthy and enhancing length and quality of life. Thus, in this study, we aimed to describe diabetes awareness, treatment targets, and treatment outcomes among Mexico City residents, as well as the inequalities in these outcomes, in order to provide evidence to better target interventions. View this paper

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5 pages, 197 KiB  
Commentary
Therapeutic Strategies for Diabetic Kidney Disease
by Keiichiro Matoba
Diabetology 2021, 2(1), 31-35; https://doi.org/10.3390/diabetology2010003 - 12 Mar 2021
Viewed by 2667
Abstract
Diabetic kidney disease (DKD) is a global epidemic leading to end-stage renal disease (ESRD) and susceptibility to cardiovascular disease, with few therapeutic interventions. A hallmark of DKD is the activation of the renin-angiotensin-aldosterone system and hemodynamic changes in glomerulus. Although intensive therapy with [...] Read more.
Diabetic kidney disease (DKD) is a global epidemic leading to end-stage renal disease (ESRD) and susceptibility to cardiovascular disease, with few therapeutic interventions. A hallmark of DKD is the activation of the renin-angiotensin-aldosterone system and hemodynamic changes in glomerulus. Although intensive therapy with agents that targets those abnormalities lowers the risk of DKD progression, it does not completely abolish the risk of ESRD and cardiovascular events. Recent studies have illustrated the importance of renal inflammation, oxidative stress, and activated Rho-associated protein kinase (ROCK) signaling as essential pathogenesis for the development of DKD. In this commentary, these topics will be discussed. Full article
15 pages, 326 KiB  
Article
Diabetes Awareness, Treatment, and Control among Mexico City Residents
by Simón Barquera, César Hernández-Alcaraz, Alejandra Jáuregui, Catalina Medina, Kenny Mendoza-Herrera, Andrea Pedroza-Tobias, Lizbeth Tolentino Mayo, Luz Elizabeth Guillen Pineda, Ruy López-Ridaura and Carlos A. Aguilar Salinas
Diabetology 2021, 2(1), 16-30; https://doi.org/10.3390/diabetology2010002 - 18 Feb 2021
Cited by 11 | Viewed by 7091
Abstract
Early diagnosis and control of diabetes can reduce premature mortality and disability. We described the diabetes prevalence, awareness, treatment, and control in Mexico City. Data came from the Mexico City Representative Diabetes Survey, conducted between May to June 2015. Participants (20–69 y, n [...] Read more.
Early diagnosis and control of diabetes can reduce premature mortality and disability. We described the diabetes prevalence, awareness, treatment, and control in Mexico City. Data came from the Mexico City Representative Diabetes Survey, conducted between May to June 2015. Participants (20–69 y, n = 1307) reported their diabetes condition, treatment, and outcomes. Fasting blood samples were collected and HbA1c, blood glucose, and blood lipids were determined. We used multivariate logistic regression to identify inequalities in diabetes prevalence and awareness. The overall prevalence of diabetes was 13.6% (95% CI: 11.7, 15.7). Of those living with diabetes, 70.5% were aware of their condition. Among those aware of their diabetes, around 10% to 65% received diabetes care according to international guidelines, and around 30% to 40% achieved HbA1c, LDL cholesterol, or blood pressure targets. Overall, only 4.1% of those aware of their diabetes achieved all treatment targets and 35.4% had never presented a diabetes complication. Diabetes prevalence was higher among older age groups and lower among the most educated. Having access to health care was associated with lower odds for diabetes and diabetes awareness. The low rates of diabetes awareness, treatment, and control highlight the urgent need of strengthening diabetes care in Mexico City. Full article
15 pages, 254 KiB  
Article
Disrupted Self-Management and Adaption to New Diabetes Routines: A Qualitative Study of How People with Diabetes Managed Their Illness during the COVID-19 Lockdown
by Dan Grabowski, Mathilde Overgaard, Julie Meldgaard, Lise Bro Johansen and Ingrid Willaing
Diabetology 2021, 2(1), 1-15; https://doi.org/10.3390/diabetology2010001 - 12 Jan 2021
Cited by 30 | Viewed by 7276
Abstract
When societies went into the COVID-19 lockdown, the conditions under which people with diabetes managed their illness dramatically changed. The present study explores experiences of everyday life during the COVID-19 lockdown among people with diabetes, and how diabetes self-management routines were affected. The [...] Read more.
When societies went into the COVID-19 lockdown, the conditions under which people with diabetes managed their illness dramatically changed. The present study explores experiences of everyday life during the COVID-19 lockdown among people with diabetes, and how diabetes self-management routines were affected. The data consist of 20 interviews with adults with diabetes, focusing on experiences during the COVID-19 lockdown. The analysis showed that experiences of self-management during lockdown were diverse and that participants handled daily life changes in very different ways. The main changes in self-management related to physical activity and food intake, which decreased and increased, respectively, for many participants during lockdown. We found two main and significantly different overall experiences of everyday life while on lockdown: (1) A daily life significantly changed by the lockdown, causing disruption of diabetes self-management routines, and (2) a largely unaffected everyday life, enabling continuance of diabetes routines. Our findings showed that people with diabetes lacked information about strategies to self-manage diabetes during lockdown and would have benefited from guidance and support throughout the pandemic, or any other crisis, to maintain their diabetes self-management routines. Full article
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