Co-Infection with Cryptosporidium meleagridis and Enterocytozoon bieneusi in an HIV+ Colombian Patient
, Alejandro Dashti 1, Pamela C. Köster 1, Begoña Bailo 1, MarÃa C. Orozco 2, Mónica SantÃn 4, David González-Barrio 1 and David Carmena 1,5,*
Round 1
Reviewer 1 Report
In general, the manuscript is well written providing a concise discussion.
Author Response
We would like to thank Reviewer #1 for his/her preliminary positive appraisal on manuscript parasitologia-2112686.
Reviewer 2 Report
First, I congratulate the authors for the manuscript. It is well written, interesting and readable. Consider the suggestions below, just as a way to contribute and refine the presentation of the report.
Overall, the language needs revision to refine some terms.
Line 27: Replace "Salmonella sp." with "Salmonella spp."; Replace "Shigella sp." with "Shigella spp.".
Keywords are too long. Some are found in the title. Suggestion: AIDS, diarrhea, enteric pathogens, molecular diagnosis, opportunistic infections.
Line 43: Replace "well-trained personnel". Suggestion: specific skills.
Line 51: Cryptosporium and Enterocytozoon must be abbreviated. Also, species names should be in italics.
Line 55-56: Replace "severe headache, or weight loss" with "severe headache and weight loss".
Line 56-58: The phrase is confusing. It needs revision to understand the content properly.
The patient's history is too detailed, especially given the purpose of the study clearly described in the title. Much of the history can be summarized, for greater textual fluidity.
Line 95-109: In this paragraph abbreviate the genus of species mentioned earlier in the text. Also, replace "sp." with "spp." for standardization,
Line 143: Remove "also".
Author Response
Reviewer #2
First, I congratulate the authors for the manuscript. It is well written, interesting and readable. Consider the suggestions below, just as a way to contribute and refine the presentation of the report.
We would like to thank Reviewer #2 for his/her preliminary positive appraisal on manuscript parasitologia-2112686.
- Line 27: Replace "Salmonella" with "Salmonella spp."; Replace "Shigella sp." with "Shigella spp.".
Reply: Corrected as per requested.
- Keywords are too long. Some are found in the title. Suggestion: AIDS, diarrhea, enteric pathogens, molecular diagnosis, opportunistic infections.
Reply: We agree with the Reviewer´s suggestion. The proposed keywords have been added to the text replacing the previous ones.
- Line 43: Replace "well-trained personnel". Suggestion: specific skills.
Reply: Replaced as per requested.
- Line 51: Cryptosporium and Enterocytozoon must be abbreviated. Also, species names should be in italics.
Reply: Corrected as per requested.
- Line 55-56: Replace "severe headache, or weight loss" with "severe headache and weight loss".
Reply: Corrected as per requested.
- Line 56-58: The phrase is confusing. It needs revision to understand the content properly.
Reply: thanks for spotting this inconsistency. The sentence has been rephrased as “The patient had a history of poor adherence to the antiretroviral therapy (ART, 300 mg tenofovir, 200 mg emtricitabine, 300 mg atazanavir, and 100 mg ritonavir once daily) but declared adherence at time of admission, which was well tolerated”.
- The patient's history is too detailed, especially given the purpose of the study clearly described in the title. Much of the history can be summarized, for greater textual fluidity.
Reply: We appreciate the comment raised by the Reviewer, but feel that this information is useful to better understand the clinical evolution of the patient and her management through the course of the infection.
- Line 95-109: In this paragraph abbreviate the genus of species mentioned earlier in the text. Also, replace "sp." with "spp." for standardization,
Reply: Genera abbreviations have been introduced in current lines 101 and 103. The species Cyclospora cayetanensis, Cystoisospora belli, Giardia duodenalis, Entamoeba histolytica, Entamoeba dispar, and Blastocystis sp. have been described in full as this is the first time that they are mentioned in the text. Finally, please note that the correct naming of Blastocystis (previously know and Blastocystis hominis) is Blastocystis sp., not Blastocystis spp. See Stensvold et al. Trends Parasitol. 2007;23(3):93-6. doi: 10.1016/j.pt.2007.01.004.
- Line 143: Remove "also".
Reply: Removed as per requested.
