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Volume 14
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10.3390/ECMC2022-13246
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Abstract

Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization †

by
Cátia Venâncio
1,*,
Bruna Monteiro
2,
Rafael Francisco
3,
Márcia C. Neves
3,
Mara G. Freire
3,
Ana Catarina A. Sousa
4 and
Isabel Lopes
1
1
Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal
2
Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
3
CICECO–Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
4
Department of Biology and Comprehensive Health Research Centre (CHRC), University of Évora, 7006-554 Évora, Portugal
*
Author to whom correspondence should be addressed.
†
Presented at the 8th International Electronic Conference on Medicinal Chemistry, 1–30 November 2022; Available online: https://ecmc2022.sciforum.net/.
Med. Sci. Forum 2022, 14(1), 101; https://doi.org/10.3390/ECMC2022-13246
Published: 1 November 2022
(This article belongs to the Proceedings of The 8th International Electronic Conference on Medicinal Chemistry)
Versions Notes

Abstract

:
Given the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement of some of these drugs aimed at decreasing patient discomfort during the administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer cytostatic and prodrugs there are no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light of the points raised, the IonCytDevice project intended to bridge some of these knowledge gaps and has delivered important benchmarks. Predictions have been obtained on the environmental impacts of three cytostatics (cyclophosphamide: CYP; 5-fluoroucil: 5-FU; and mycophenolic acid: MPA) and one prodrug (capecitabine: CAP) on freshwater biota, with a focus on new species and endpoints likely to be also framed in meta-analysis studies. The results reveal that, for now, CYP, 5-FU, and CAP (prodrug) pose no risk, whilst MPA was flagged as a high environmental risk.

Author Contributions

Conceptualization, C.V., A.C.A.S. and I.L.; methodology, M.C.N. and I.L.; validation, A.C.A.S. and I.L.; formal analysis, C.V. and B.M.; investigation, B.M., R.F.; resources, M.G.F. and I.L.; data curation, C.V., A.C.A.S. and I.L.; writing—original draft preparation, C.V. and B.M.; writing—review and editing, C.V., R.F., M.C.N.; M.G.F., A.C.A.S. and I.L.; visualization, C.V., A.C.A.S. and I.L.; supervision, M.G.F., A.C.A.S. and I.L.; project administration, M.G.F., A.C.A.S. and I.L.; funding acquisition, M.G.F. and I.L. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by FEDER, through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI), and by national funds (OE), through FCT/MCTES grant number POCI-01-0145-FEDER-031106 (IonCytDevice—PTCD/BTA-BTA/31106/2017).

Conflicts of Interest

The authors declare no conflict of interest.
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Share and Cite

MDPI and ACS Style

Venâncio, C.; Monteiro, B.; Francisco, R.; Neves, M.C.; Freire, M.G.; Sousa, A.C.A.; Lopes, I. Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization. Med. Sci. Forum 2022, 14, 101. https://doi.org/10.3390/ECMC2022-13246

AMA Style

Venâncio C, Monteiro B, Francisco R, Neves MC, Freire MG, Sousa ACA, Lopes I. Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization. Medical Sciences Forum. 2022; 14(1):101. https://doi.org/10.3390/ECMC2022-13246

Chicago/Turabian Style

Venâncio, Cátia, Bruna Monteiro, Rafael Francisco, Márcia C. Neves, Mara G. Freire, Ana Catarina A. Sousa, and Isabel Lopes. 2022. "Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization" Medical Sciences Forum 14, no. 1: 101. https://doi.org/10.3390/ECMC2022-13246

APA Style

Venâncio, C., Monteiro, B., Francisco, R., Neves, M. C., Freire, M. G., Sousa, A. C. A., & Lopes, I. (2022). Ecotoxicological Tools to Assess Cytostatic Effects in Freshwater Environments: Aiding Drug Prioritization. Medical Sciences Forum, 14(1), 101. https://doi.org/10.3390/ECMC2022-13246

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