The “Gene and Cell Therapy” Section publishes contributions of the latest research results concerning all aspects of gene and cell therapy. We encourage the submission of manuscripts that provide novel and mechanistic insights, as well as report significant advances in the therapeutic delivery of nucleic acids into a patient's cells for the treatment of various diseases.

1. “The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells”
by Agnieszka Kulesza, Leszek Paczek and Anna Burdzinska
Biomedicines 2023, 11(2), 445; https://doi.org/10.3390/biomedicines11020445
Available online: https://www.mdpi.com/2227-9059/11/2/445

2. “Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment”
by Elena M. Tosca, Davide Ronchi, Daniele Facciolo and Paolo Magni
Biomedicines 2023, 11(4), 1058; https://doi.org/10.3390/biomedicines11041058
Available online: https://www.mdpi.com/2227-9059/11/4/1058

3. “SERPINA3: Stimulator or Inhibitor of Pathological Changes”
by Mateusz de Mezer, Jan Rogaliński, Stanisław Przewoźny, Michał Chojnicki, Leszek Niepolski, Magdalena Sobieska and Agnieszka Przystańska
Biomedicines 2023, 11(1), 156; https://doi.org/10.3390/biomedicines11010156
Available online: https://www.mdpi.com/2227-9059/11/1/156

4. “Gene Therapy with Voretigene Neparvovec Improves Vision and Partially Restores Electrophysiological Function in Pre-School Children with Leber Congenital Amaurosis”
by Maximilian J. Gerhardt, Claudia S. Priglinger, Günther Rudolph, Karsten Hufendiek, Carsten Framme, Herbert Jägle, Daniel J. Salchow, Andreas Anschütz, Stylianos Michalakis and Siegfried G. Priglinger
Biomedicines 2023, 11(1), 103; https://doi.org/10.3390/biomedicines11010103
Available online: https://www.mdpi.com/2227-9059/11/1/103

5. “Development of a TGFβ—IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy”
by Carole Beck, Nicholas Paul Casey, Irene Persiconi, Neda Nejati Moharrami, Adam Sike, Yixin Jin and Jon Amund Kyte
Biomedicines 2023, 11(2), 459; https://doi.org/10.3390/biomedicines11020459
Available online: https://www.mdpi.com/2227-9059/11/2/459

6. “Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease”
by Lingling Sun, Justine Mailliot and Christiane Schaffitzel
Biomedicines 2023, 11(3), 722; https://doi.org/10.3390/biomedicines11030722
Available online: https://www.mdpi.com/2227-9059/11/3/722

7. “A Narrative Review of Cytokine Networks: Pathophysiological and Therapeutic Implications for Inflammatory Bowel Disease Pathogenesis”
by Marek Vebr, Renáta Pomahačová, Josef Sýkora and Jan Schwarz
Biomedicines 2023, 11(12), 3229; https://doi.org/10.3390/biomedicines11123229
Available online: https://www.mdpi.com/2227-9059/11/12/3229

8. “Unlocking the Pragmatic Potential of Regenerative Therapies in Heart Failure with Next-Generation Treatments”
by Yoshikazu Kishino and Keiichi Fukuda
Biomedicines 2023, 11(3), 915; https://doi.org/10.3390/biomedicines11030915
Available online: https://www.mdpi.com/2227-9059/11/3/915

9. “Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review”
by Lucia Finocchio, Marco Zeppieri, Andrea Gabai, Giacomo Toneatto, Leopoldo Spadea and Carlo Salati
Biomedicines 2023, 11(12), 3221; https://doi.org/10.3390/biomedicines11123221
Available online: https://www.mdpi.com/2227-9059/11/12/3221

10. “A Prospective Study on the Roles of the Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Locally Advanced Rectal Cancer”
by Cieszymierz Gawiński, Andrzej Mróz, Katarzyna Roszkowska-Purska, Iwona Sosnowska, Edyta Derezińska-Wołek, Wojciech Michalski and Lucjan Wyrwicz
Biomedicines 2023, 11(11), 3048; https://doi.org/10.3390/biomedicines11113048
Available online: https://www.mdpi.com/2227-9059/11/11/3048

We would like to take this opportunity to thank all the research groups that have submitted their papers to Biomedicines (ISSN: 2227-9059). We would appreciate it if you could circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Launching a Special Issue:
You have the opportunity to propose hot topics and edit a Special Issue together with experts in the field.

Joining the Editorial Board:
If you are an active researcher in the fields of mineral processing and extractive metallurgy and are interested in joining the Editorial Board, please do not hesitate to get in touch ([email protected]).

Biomedicines Editorial Office