Optimizing Antimicrobial Therapy in NICU Settings: Strategies and Implications
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 151
Special Issue Editors
Interests: antimicrobial resistance; antimicrobial stewardship; infection control and prevention; diagnostic stewardship
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial resistance; antimicrobial stewardship; infection control and prevention; diagnostic stewardship; neonatal pharmacology
Special Issue Information
Dear Colleagues,
Currently, there is a lack of high-quality evidence supporting optimal therapeutic strategies/management of either early or late neonatal sepsis among full-term neonates and, most importantly, among high-risk preterm neonates. This knowledge gap frustrates neonatologists and introduces a great diversity in clinical practices among NICUs. In the absence of a diagnostic biomarker for neonatal sepsis, the optimal response timing and rationale of the antimicrobial initiation protocol remain a challenge in the NICU. Optimization of the antimicrobial regimen (which antibiotic/dose/administration route) in neonates is a cornerstone for improving effectiveness and reducing the risk of antibiotic resistance and drug toxicity. Antimicrobial stewardship programs should customize their activities according to NICU epidemiology and particularities.
The role of antimicrobial treatment in the neonatal gut microbiome and resistome is far from being established, especially in the era of increasing antimicrobial resistance. Similarly, the role of newer antimicrobials and particularly their judicious use through antimicrobial stewardship programs in NICU should be further assessed and carefully refined.
The present Special Issue is focused on optimizing antimicrobial therapy in NICU settings, including strategies and implications. We invite you to participate with your original research or with high-quality review articles in this endeavor. Researchers from various scientific communities are welcome to present their latest research and discuss common themes and challenges on this topic.
Dr. Elias Iosifidis
Dr. Angeliki Kontou
Guest Editors
Manuscript Submission Information
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Keywords
- neonatal ICU
- antimicrobial stewardship
- antimicrobial resistance
- neonatal sepsis
- biomarkers
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