Harnessing Genetics and Biochemistry to Discover Novel Antimicrobials
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Genetic and Biochemical Studies of Antibiotic Activity and Resistance".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 281
Special Issue Editors
Interests: bacterial cell cycle; mechanism and regulation of chromosomal replication initiation; initiator proteins; DNA methylation; antibiotic inhibition of chromosome replication; designing whole cell screens for discovery of new antibiotics; antimicrobial peptides
Special Issues, Collections and Topics in MDPI journals
Interests: implant-associated infections; anti-infective substances and strategies; virulence factors; bacterial biofilm; bacterial molecular epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the threat of drug-resistant infections looms, the quest for innovative antimicrobial solutions becomes increasingly vital. Natural products remain a major source of novel antimicrobials, recently accelerated by advances in DNA sequencing, enabling the rapid identification of biosynthetic clusters for putative antimicrobial products, some derived from non-culturable organisms. Recent advances in genetics and biochemistry have revolutionized our capacity to uncover and engineer these bioactive molecules. Genetic engineering allows for enhanced biosynthetic capabilities, novel pathway creation, and production optimization. The focus is also on putative antimicrobials from non-natural sources, including chemical libraries, aptamers, randomized peptide libraries, etc. Irrespective of source, genetic and biochemical analyses help unravel modes of action, process optimization, delivery and putative resistance mechanisms.
We invite researchers from microbiology, molecular biology, biotechnology, and pharmaceutical sciences to contribute their groundbreaking findings and methodologies to this essential field.
Prof. Dr. Anders Løbner-Olesen
Dr. Stefano Ravaioli
Guest Editors
Manuscript Submission Information
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Keywords
- novel antimicrobials
- genetics
- biochemistry
- DNA sequencing
- genetic engineering
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