Nanocarriers for Drug and Gene Delivery: Novel Scenarios in Nanotechnology
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 417
Special Issue Editor
Interests: nano- and biomaterials; nanoformulations; 3D cell cancer models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The advent of the nanotechnologies and their application in the biomedical area, including the development of new diagnostic approaches and therapeutic tools, has revolutionized scientific research in the last 25 years. The number of published papers in this topic is impressive, witnessing on the one hand the liveliness and the general interest that it attracts and on the other the broken promise of the vast majority of the developed nanotechnologies to reach the patient's bed. The poor clinical translation of nano-based approaches involves several aspects, including the limited efficacy of the proposed systems in vivo and the high costs of production and testing.
The COVID pandemic has upset these rules, ushering in a new era in nanotechnologies applied to human health. The development and adoption of vaccines based on nanocarriers has caught the attention of public opinion, engendering the following questions: What are they made of? How do they work? Which are the benefits of their use? Which risks do they pose? These are questions that require clear and thorough answers.
In this context, this Special Issue aims to collect the most recent trends on nanotechnologies-based carriers for drug and gene delivery. Research studies encompassing new synthetic approaches of nanocarriers or the encapsulation of novel pharmaceuticals (synthetic or natural compounds, and DNA or RNA sequences) into nanoparticles are encouraged. In addition, in vitro, preclinical and clinical studies analysing the short- and long-term effects of the nanocarriers defining their pharmacokinetics, biodistribution, bioaccumulation, clearance and degradation are considered of great interest. Application fields may include cancer, neurodegenerative diseases, infections or immune diseases and are not limited to them.
In this Special Issue, original research articles and reviews are welcome.
Dr. Alessandra Quarta
Guest Editor
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Keywords
- Nanoparticles
- Drug
- Delivery
- Nanomedicine
- Biodistribution
- Efficacy
- Bioaccumulation
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