Innovative Approaches in Drug Discovery
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 337
Special Issue Editor
Interests: proteolysis targeting chimeras (PROTACs); molecular glue degrader; cancer research; E3 ubiquitin ligases; small molecule drug development; drug-binding proteins (DBPs)
Special Issue Information
Dear Colleagues,
Recent advancements in drug discovery are transforming the field with innovative methodologies that enhance efficiency and precision. Key developments include:
- Artificial Intelligence and Machine Learning: AI and machine learning improve drug discovery by predicting interactions between small molecules and target proteins. These technologies accelerate the identification of lead molecules and streamline the discovery process.
- Personalized Medicine: Advances in genomics allow for treatments tailored to individual genetic profiles, enhancing therapy effectiveness and minimizing side effects. Gene-editing technologies like CRISPR/Cas9 further facilitate targeted therapy development and disease mechanism understanding.
- High-throughput Screening (HTS): HTS automates the testing of thousands of compounds, rapidly identifying promising molecules with potential therapeutic effects, thus speeding up the drug discovery process.
- Targeted Protein Degradation: This approach, using tools like PROTACs and molecular glues, focuses on selectively degrading disease-causing proteins through natural cellular degradation systems, offering new avenues for targeted therapies.
- Structural Biology and Molecular Modeling: Advanced imaging (X-ray crystallography, NMR, cryo-EM) and computational methods provide detailed insights into drug target structures and interactions, aiding in the design and optimization of specific and effective drugs.
- Drug Repurposing: Discovering new uses for existing drugs leverages established safety profiles and mechanisms, expediting the development of treatments for various conditions.
Dr. Jitendra Gour
Guest Editor
Manuscript Submission Information
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Keywords
- PROTACs
- molecular glue
- personalized medicine
- high-throughput screening (HTS)
- targeted therapy
- drug repurposing
- safety profiles
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