Histiocytosis and Treatment Targets
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 160
Special Issue Editor
Interests: ECD advocate; Histiocytosis; pharmacology; cardiac devices; cardiac hypertrophy; aortic stiffening; gene pathways; atrial fibrillation; ventricular tachycardia; HRV; COVID-19
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Histiocytosis encompasses intriguing rare blood cancer disorders characterized by the accumulation of tissue histocytes, often accompanied by inflammatory infiltrates. Histiocytosis is considered a clonal disorder with a high frequency of somatic mutations resulting in activation of the MEK–ERK signaling pathway. Recent breakthroughs in understanding the mitogen-activated protein kinase (MAPK) pathway have identified therapeutic strategies with targeted therapies for this pathway. However, the disease can still be difficult to manage in terms of efficacy for MAPK pathway targets in individual patients. Other considerations include access to costly medications, tolerability and toxicity. Hence, other pharmacological considerations are warranted, including new targets of combinational therapy. The cost of targeted therapy and equity are recurring themes for the patient. We invite authors to explore the intricate interplay between histiocytosis and pharmacology, with a focus on Langerhans cell histiocytosis, Erdheim–Chester disease and juvenile xanthogranuloma. The topics of interest may include, but are not limited to, gene pathway analysis of targeted therapy, health system models of therapeutic access to targeted therapy, complexity of RAS mutations as druggable targets, toxicity with targeted therapy, “drug holidays” and resistance. Join us in unravelling the mysteries of therapeutic targets and outcomes in histiocytosis.
Prof. Dr. Craig Steven McLachlan
Guest Editor
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Keywords
- in silico
- histiocytosis
- ECD
- LCH
- pharmacology
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