Liquid Biopsy Applications and Challenges
A special issue of BioTech (ISSN 2673-6284). This special issue belongs to the section "Medical Biotechnology".
Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 413
Special Issue Editor
Interests: liquid biopsy; precision medicine; regenerative medicine; stem cells; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Liquid biopsy is not literally a biopsy, but is a new diagnostic concept applied to optimize the management and follow up for cancer patients by using circulating tumor cells (CTC), cell free DNA (cfDNA), cell free RNA (cfRNA) and micro-RAN (miRNA) that are released from primary tumor or metastatic deposits into the peripheral blood or body fluids.
Liquid biopsy is not an invasive procedure, and it aims to detect target molecules, monitor therapeutic response and resistance, avoid repeat tissue biopsies where the tissue is not available and predict prognosis. Hence, liquid biopsy has become the leading molecular technique for precision medicine.
Several techniques are used to conduct this test, including PCR-based detection techniques, next generation sequencing (NGS)-based detection techniques and immunological antibodies for receptors on the surface of CTC.
On the other hand, a series of clinical validations are needed before we can adopt this technique for diagnostic purposes.
In fact, the applications of liquid biopsy go beyond the field of oncology, such as in the fields of obstetrics, cardiology and pediatrics.
Dr. John Yahya I. Elshimali
Guest Editor
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Keywords
- indications of liquid biopsy
- sources of samples
- liquid biopsy techniques
- application of liquid biopsy in malignancies
- application of liquid biopsies on other diseases
- limitations of liquid biopsies
- optimizing of liquid biopsy application
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