Effects of Radiotherapy on the Tumor Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 259
Special Issue Editors
Interests: immunotherapy; tumor microenvironment; biomarker
Interests: onco-immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Whilst the direct DNA damaging effects of radiotherapy are well known, in more recent years it has become apparent that radiotherapy can also have multiple effects on the tumor microenvironment (TME) including recruitment of immune cells. Whilst radiotherapy can induce the recruitment of immune stimulatory cells into the TME, it can also induce immune-suppressive cells, and the balance between these immune cells can dictate whether radiotherapy is able to generate anti-tumor immune responses which can improve patient outcomes.
Some pre-clinical models demonstrate that radiotherapy can prime responses which are dependent on T-cell infiltration into the tumor. However, in other tumor models which are devoid of T-cells and contain high numbers of myeloid cells, radiotherapy appears instead to cause further infiltration of suppressive myeloid cells. Furthermore, instances of abscopal responses are rarely described in the clinic, and trials of radiotherapy and immune checkpoint inhibitors have to date been limited.
This Special Issue will delve deep into how radiotherapy can affect the tumor microenvironment, mechanisms of immune responses to radiotherapy and potential immune biomarkers of radiotherapy response, along with papers which detail how potential biomarkers might be used to determine effective radiotherapy-immunotherapy combinations through mechanistic studies in pre-clinical models.
Dr. Eleanor J. Cheadle
Dr. Jamie Honeychurch
Guest Editors
Manuscript Submission Information
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Keywords
- radiotherapy
- tumor microenvironment
- immune response
- biomarkers
- stroma
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