NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (22 November 2024) | Viewed by 305
Special Issue Editors
Interests: immunology; viral infectious diseases; cancer immunology
Special Issue Information
Dear Colleagues,
Natural killer (NK) cells represent the innate counterparts of cytotoxic T lymphocytes, poised to rapidly engage in cell-mediated cytotoxicity and the release of potent proinflammatory cytokines. Their functions are largely regulated through surface-activating and inhibitory receptors which probe their tissue microenvironment for signs of infection or malignancy. Therapeutic manipulation of these opposing receptors holds great promise for clinical intervention. In this Special Issue, we explore the mechanisms malignant cells employ to inhibit NK cell surveillance, as well as therapeutic strategies to overcome these immunosuppressive pathways and enhance NK cell activity.
Dr. Alexander Barrow
Dr. Julian Vivian
Guest Editors
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Keywords
- immunosuppression
- activation
- inhibition
- receptor
- NK-CAR
- checkpoint
- adoptive cell therapy
- immunotherapy
- tumor microenvironment
- nanoparticles
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