Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 133
Special Issue Editors
Interests: cervical cancer; ovarian cancer; endometrial cancer; sentinel lymph node; robotic surgery
Interests: cervical cancer; lymph nodes; metastasis; breast cancer; prevention
Interests: cervical cancer; lymph nodes; metastasis; breast cancer; prevention
Special Issue Information
Dear Colleagues,
Most positive lymph nodes are classified as either macro- or micrometastases (MACs or MICs). Isolated tumor cells (ITCs), which are cell clusters, are not considered to be metastasis. However, as more long-term data become available, ITCs have been proven to be precursors to lymph node metastasis and could potentially impact survival outcomes. Low-volume lymph node disease (ITCs, MICs) is commonly observed in sentinel lymph nodes (SLNs), and in rare cases, it may also be found in non-sentinel lymph nodes (nSLNs). The risk of lymph node involvement is independently associated with tumor size (increased FIGO stage), lymphovascular space invasion (LVSI), and depth of invasion, including deep stromal and myometrial.
When identified bilaterally, the status of SLNs is a key indicator of the status of the remaining lymph nodes. In the case of the missed identification of SLNs, it becomes challenging to reliably asssess the lymph nodes on a given side due to the risk of false diagnosis and potential understaging. Extending SLNs analysis though ultrastaging and the use of immunohistochemical techniques enables access to be gained to more reliable information on cervical cancers’ stage and prognosis. In the future, newer techniques such as image guiding will improve the accuracy of these data.
This approach supports the deepening of our understanding of the biological behavior of cervical cancer and the mechanisms of its spread, particularly by identifying locations of cancer cells that could be targeted therapeutically.
We welcome original research articles and reviews to be submitted to this Special Issue, encompassing research areas such as immune pathology, SLN mapping, and imaging.
We look forward to receiving your contributions.
Dr. Vincent Balaya
Dr. Marcin Sniadecki
Dr. Thomas Gaillard
Guest Editors
Manuscript Submission Information
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Keywords
- cervical cancer
- lymph nodes
- metastasis
- isolated Tumor Cells
- sentinel lymph node
- non-sentinel lymph node
- tumor-draining lymph nodes
- microenvironment
- one-step nucleic acid amplification
- imaging
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