Signaling Pathways in Breast Cancer: 2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 11 April 2025 | Viewed by 155
Special Issue Editor
Interests: carcinogenesis and metastases; chemoprevention; drug resistance; radiation resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the Special Issue “Signaling Pathways in Breast Cancer”, available at: https://www.mdpi.com/journal/cancers/special_issues/Signaling_Pathways_Breast_Cancer.
Breast cancer is a major cause of death among women in the Western world, who have a significant lifetime risk of developing the disease. Nearly 40,000 women succumb to breast cancer every year in the United States alone. Breast cancer is a heterogeneous disease broadly classified into subtypes, each with a distinct gene expression signature, including luminal-type, basal-like, human epidermal growth factor receptor 2-positive, and normal-like. Metastasis to multiple organs is the primary cause of mortality in breast cancer patients. HER2 is an important determinant of poor prognosis in breast cancer patients, and HER2-positive tumors are mostly resistant to therapy and have high metastatic potential. In addition, this Special Issue intends to provide a succinct overview of the availability and relevance of the major categories of mouse models for breast cancer. This Special Issue will concentrate on the latest achievements in developing genetically engineered mice (GEM) with conditional knockout alleles or models that allow the inducible expression of oncogenes in mammary epithelial cells.
Thus, this Special Issue aims to attract original research articles, clinical studies, and review articles describing the current findings on therapeutically promising natural products or small molecule inhibitors for future clinical use. We invite authors to submit articles exploring aspects of the therapeutic potential of natural products and/or small molecule inhibitor(s) in treating and suppressing breast cancer progression and metastasis.
Prof. Dr. Sharad S. Singhal
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- angiogenesis
- apoptosis
- breast cancer metastasis
- breast cancer stem cells
- cancer invasion
- chemoprevention
- epithelial-to-mesenchymal transition
- ERα/ERBB2/HER2/NFκB/Notch3/TGFβ signaling
- mammary carcinogenesis
- mitochondrial dynamics
- tumor microenvironment
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