The Warburg Centennial: Past Progress and Future Directions
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 227
Special Issue Editor
Interests: computational drug design; systems biology of cancer and neurodegenerative diseases; tubulin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The year 2024 marks the 100th anniversary of the Warburg effect, the name given to the phenomenon wherein Otto Warburg observed preferential glycolytic metabolism in cancer cells. Normally, the cell only adopts glycolysis in anaerobic conditions, such as the transient hypoxia, which is characterized by intense muscular exertion for short periods. However, among all the cancer cell types that Warburg examined, all were preferentially using a glycolytic metabolism.
This groundbreaking discovery took considerable time to percolate through the scientific community, owing to oncology being predominantly focused on genetic factors and DNA damage as the potentiators of cancer. However, in the past decade, there has been a resurgence of interest in cancer metabolism, and some successful trials of low carbohydrate, ketogenic diets, which effectively deprive cancer cells of their preferred energy source.
While significant and rapid progress is being made, questions still remain, including how we may tailor treatment to a given cancer type, and how the metabolic state of ketosis interacts with anticancer agents. Additionally, economic and societal implications abound, as metabolic approaches are potentially much more accessible and low-cost. Metabolic and systemic approaches for many diseases have been neglected as possibilities in lieu of rationally designed drugs with high specificity for a singular target.
This Special Issue solicits contributions on the metabolic implications of cancer and treatment via altering metabolism. This issue includes, but is not limited to
(1) Ketogenic diets and fasting for cancer treatment and prevention;
(2) Alterations of metabolism for cancer treatment and prevention through lifestyle, dietary, nutraceutical and pharmaceutical interventions;
(3) The molecular and systems biology mechanisms of the action of metabolic reprogramming in cancer;
(4) The molecular and systems biology mechanisms of the action of interventions targeting cancer metabolism;
(5) Epidemiological studies of cancer incidence, taking into account metabolic and dietary factors;
(6) Other non-dietary factors influencing metabolism, such as stress, sleep, light exposure, temperature, and exercise.
We look forward to receiving your contributions.
Prof. Dr. Jack Tuszynski
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer metabolism
- glycolytic metabolism
- cancer treatment
- cancer prevention
- molecular
- systems biology mechanisms
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